O28669 (TRPE_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	AF_1603

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	Anthranilate synthase component 1		PRO_0000154121

Sequences

	Sequence		Length	Mass (Da)
	O28669 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 2D65F91E5BF4457A	FASTA	411	46,346
	10 20 30 40 50 60 MQKHEYVNPV KLYSAIRDEK FPFILESAEK SGRARYTYIS FNPLYTVRVG SRTRVDGEVI 70 80 90 100 110 120 SKISDPFDAL NEIHVKGLLV GYVAYEAVKN YIGKKPQTPS VFGCYDGYFV YDHYLRKLFS 130 140 150 160 170 180 VNVENADKIV ERAKRVEVEQ VRGNSEVLRA GSREKFEKMV ERGKEQIFEG EVYQIVLSRE 190 200 210 220 230 240 YVVDTDLSPF QMYLNLRETN PSPYMFLLEF DRALIGSSPE TMGRVEGNSF IINPIAGTAR 250 260 270 280 290 300 REAGREKEIA EKLLSDEKER AEHVMLVDLA RNDVRKVCRA GSVRVSRFME VVEYPSVLHI 310 320 330 340 350 360 ESEVVGELKA GVTHFDAMKA TFPAGTVTGA PKLRAIELID EIEGDCRGVY AGAVGYFSEN 370 380 390 400 410 VSDLAIAIRM IEFDGKARIR AGAGIVADSV PEREFFETEN KIARVLRAVG L

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB89646.1.
PIR	B69450.
RefSeq	NP_070432.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O28669.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1484829.
GenomeReviews	Gene locus AF_1603 in contig AE000782_GR.
KEGG	afu:AF1603.
NMPDR	fig|224325.1.peg.1593.
TIGR	AF_1603.
Phylogenomic databases
HOGENOM	HBG507440.
OMA	TENKIAR.
PhylomeDB	O28669.
ProtClustDB	PRK13572.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_1603-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_ARCFU

Accession

Primary (citable) accession number: O28669

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program