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O28668 (TRPCD_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tryptophan biosynthesis protein TrpCD

Including the following 2 domains:

  1. Indole-3-glycerol phosphate synthase
    Short name=IGPS
    EC=4.1.1.48
  2. Anthranilate phosphoribosyltransferase
    EC=2.4.2.18
Gene names
Name:trpCD
Ordered Locus Names:AF_1604
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the second and fourth steps of tryptophan biosynthetic pathway. The second step is catalyzed by the anthranilate phosphoribosyltransferase, coded by the TrpD domain and the fourth step is catalyzed by indole-3-glycerol phosphate synthase, coded by the TrpC domain. HAMAP MF_00134_A

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00134_A

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5. HAMAP MF_00134_A

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.

Sequence similarities

In the N-terminal section; belongs to the TrpC family.

In the C-terminal section; belongs to the anthranilate phosphoribosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Tryptophan biosynthesis protein TrpCD HAMAP MF_00134_A
PRO_0000154507

Regions

Region1 – 226226Indole-3-glycerol phosphate synthase HAMAP MF_00134_A
Region227 – 546320Anthranilate phosphoribosyltransferase HAMAP MF_00134_A

Sequences

Sequence LengthMass (Da)Tools
O28668 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 289FF9AE07F08D5A

FASTA54659,328
        10         20         30         40         50         60 
MMDFGFVDSL KGASKRGKNA VIAEVKVRSP IHGDLLRGRR IEDILRAYEK AGAAAISYIT 

        70         80         90        100        110        120 
AEQFSGNFET LKKIVGLTDL PVLRKDFIRG RKEVERTAEV EAAALLLIAR HLKERTAEMV 

       130        140        150        160        170        180 
DFCFEHGIEP LVEVHHAEDL VYAENARAVL INNRDIDRME RDGGSIDVTA KIAEKIRAFK 

       190        200        210        220        230        240 
VSGSGIGSVE DLLFVLQYVD AALIGTAFMM AENTEEFVQT VCGGEKMIED VLRGLDFDKA 

       250        260        270        280        290        300 
YELAKTLPEL DEIKIAAVLA ALEAKGYGAE VIAGFAKGVA EKSKIEIGKV MDTCGTGGDK 

       310        320        330        340        350        360 
TSSINVSTAV AIALSTVHPV AKHGNRAVSS KSGSADVLEA LGVRIEMDEE RARKMIAETN 

       370        380        390        400        410        420 
FAFLFAPLYH KSFARVAAVR RNLGIRTIFN VTGPLTNPAR PEVQIVGVAS EILLVEVAKA 

       430        440        450        460        470        480 
MSLLGRRAVV VYGSGMDEVN PNSSTDIAVV NGGVERLKLE PEDFGIERCR VLPCSSSGES 

       490        500        510        520        530        540 
AERIRAVFSG KGLKEDRRLI AINFATALFA LGYEDLKENV EIFEEKVQSG ELARKLEEIA 


CKSTSM

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB89645.1.
PIRC69450.
RefSeqNP_070433.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28668.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1484830.
GenomeReviewsGene locus AF_1604 in contig AE000782_GR.
KEGGafu:AF1604.
NMPDRfig|224325.1.peg.1594.
TIGRAF_1604.

Phylogenomic databases

PhylomeDBO28668.

Enzyme and pathway databases

BioCycAFUL224325:AF_1604-MONOMER.

Family and domain databases

HAMAPMF_00134_A. IGPS_A. Fused.
[Tree]
MF_00211. TrpD. Fused.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N.
IPR020072. Glycosyl_Trfase_fam3_subgr_N.
IPR013798. Indole-3-glycerol_P_synth.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
G3DSA:1.20.970.10. Glyco_trans_3. 2 hits.
G3DSA:3.40.1030.10. Glyco_trans_3. 2 hits.
KOK13497.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF52418. Glyco_trans_3. 1 hit.
SSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR01245. TrpD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPCD_ARCFU
AccessionPrimary (citable) accession number: O28668
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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