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Protein

Proline--tRNA ligase

Gene

proS

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:AF_1609
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001393501 – 471Proline--tRNA ligaseAdd BLAST471

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF1609

Structurei

3D structure databases

ProteinModelPortaliO28664
SMRiO28664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00402 Archaea
COG0442 LUCA
KOiK01881
OMAiEVYWVTH
OrthoDBiPOG093Z01RZ

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

O28664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPSKENFS EWYHEVIQTA EIMDVRYPVK GLYVWFPFGF KIRQLVYSKL
60 70 80 90 100
REIMDREHDE VYFPALIPET ELGKEGEHIK GFEDEVYWIT HGGLTPLDVK
110 120 130 140 150
LALRPTSETA MYPMFRLWVR NHADLPLKVY QIVNTFRYET KHTRPLIRLR
160 170 180 190 200
EITSFKEAHT VHKDFEEAAE HVKKAIGFYK EFYDFLAIPY MVIRRPEWDK
210 220 230 240 250
FPGAAYTIAF DTIMPDGRTL QIGTVHHLAD NFARTFDIKY EAPNGEHYYA
260 270 280 290 300
HQTCYGISER CIAALISVHG DDLGLVLPFE VAPVQIVIIP ILYKGKEEAV
310 320 330 340 350
MEACRKLAEK LKAFRVVLDE GEDRPGAKYY KWELKGVPIR FEIGPRDAEK
360 370 380 390 400
GVAVVSFRDE KRKFEVPLDE VDEGKVLEWA RELKQRLRNA AAERMAEKVK
410 420 430 440 450
FVENTGEIEE WGGVVAVYLC SDEDCGHSVE EHGKSLLGWF EEVPDWLDLE
460 470
PEGKCVVCGR EGRLAALAKT Y
Length:471
Mass (Da):54,521
Last modified:September 5, 2006 - v2
Checksum:iE730F9B2BED26F00
GO

Sequence cautioni

The sequence AAB89637 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89637.1 Different initiation.
PIRiH69450

Genome annotation databases

EnsemblBacteriaiAAB89637; AAB89637; AF_1609
KEGGiafu:AF_1609

Entry informationi

Entry nameiSYP_ARCFU
AccessioniPrimary (citable) accession number: O28664
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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