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Protein

Proline--tRNA ligase

Gene

proS

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:AF_1609
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001393501 – 471Proline--tRNA ligaseAdd BLAST471

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF1609.

Structurei

3D structure databases

ProteinModelPortaliO28664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00402. Archaea.
COG0442. LUCA.
KOiK01881.
OMAiIRRPEWD.

Family and domain databases

CDDicd00778. ProRS_core_arch_euk. 1 hit.
Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR033721. ProRS_core_arch_euk.
[Graphical view]
PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SMARTiSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O28664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPSKENFS EWYHEVIQTA EIMDVRYPVK GLYVWFPFGF KIRQLVYSKL
60 70 80 90 100
REIMDREHDE VYFPALIPET ELGKEGEHIK GFEDEVYWIT HGGLTPLDVK
110 120 130 140 150
LALRPTSETA MYPMFRLWVR NHADLPLKVY QIVNTFRYET KHTRPLIRLR
160 170 180 190 200
EITSFKEAHT VHKDFEEAAE HVKKAIGFYK EFYDFLAIPY MVIRRPEWDK
210 220 230 240 250
FPGAAYTIAF DTIMPDGRTL QIGTVHHLAD NFARTFDIKY EAPNGEHYYA
260 270 280 290 300
HQTCYGISER CIAALISVHG DDLGLVLPFE VAPVQIVIIP ILYKGKEEAV
310 320 330 340 350
MEACRKLAEK LKAFRVVLDE GEDRPGAKYY KWELKGVPIR FEIGPRDAEK
360 370 380 390 400
GVAVVSFRDE KRKFEVPLDE VDEGKVLEWA RELKQRLRNA AAERMAEKVK
410 420 430 440 450
FVENTGEIEE WGGVVAVYLC SDEDCGHSVE EHGKSLLGWF EEVPDWLDLE
460 470
PEGKCVVCGR EGRLAALAKT Y
Length:471
Mass (Da):54,521
Last modified:September 5, 2006 - v2
Checksum:iE730F9B2BED26F00
GO

Sequence cautioni

The sequence AAB89637 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89637.1. Different initiation.
PIRiH69450.
RefSeqiWP_048064425.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89637; AAB89637; AF_1609.
GeneIDi24795355.
KEGGiafu:AF_1609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89637.1. Different initiation.
PIRiH69450.
RefSeqiWP_048064425.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO28664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1609.

Protocols and materials databases

DNASUi1484834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89637; AAB89637; AF_1609.
GeneIDi24795355.
KEGGiafu:AF_1609.

Phylogenomic databases

eggNOGiarCOG00402. Archaea.
COG0442. LUCA.
KOiK01881.
OMAiIRRPEWD.

Family and domain databases

CDDicd00778. ProRS_core_arch_euk. 1 hit.
Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3. 1 hit.
InterProiIPR002314. aa-tRNA-synt_IIb.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR033721. ProRS_core_arch_euk.
[Graphical view]
PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SMARTiSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYP_ARCFU
AccessioniPrimary (citable) accession number: O28664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.