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Protein
Submitted name:

Adenylylsulfate reductase, subunit A (AprA)

Gene

AF_1670

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74ADP analogCombined sources1
Binding sitei74SubstrateCombined sources1
Binding sitei95ADP analogCombined sources1
Binding sitei95AMPCombined sources1
Binding sitei141SubstrateCombined sources1
Binding sitei145ADP analogCombined sources1
Binding sitei145AMPCombined sources1
Binding sitei214FAD; via carbonyl oxygenCombined sources1
Binding sitei234SubstrateCombined sources1
Binding sitei265ADP analogCombined sources1
Binding sitei265FAD cofactor analogCombined sources1
Binding sitei265SubstrateCombined sources1
Binding sitei277AMPCombined sources1
Binding sitei282AMP; via carbonyl oxygenCombined sources1
Binding sitei292AMPCombined sources1
Binding sitei317ADP analogCombined sources1
Binding sitei317AMPCombined sources1
Binding sitei361SubstrateCombined sources1
Binding sitei365FADCombined sources1
Binding sitei397FADCombined sources1
Active sitei398Proton donor/acceptorCombined sources1
Binding sitei439FAD cofactor analog; via amide nitrogenCombined sources1
Binding sitei439FAD; via amide nitrogenCombined sources1
Binding sitei449FADCombined sources1
Binding sitei449FAD cofactor analogCombined sources1
Sitei449Important for catalytic activityCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 33FADCombined sources2
Nucleotide bindingi32 – 33FAD cofactor analogCombined sources2
Nucleotide bindingi56 – 57FADCombined sources2
Nucleotide bindingi56 – 57FAD cofactor analogCombined sources2
Nucleotide bindingi63 – 65FADCombined sources3
Nucleotide bindingi63 – 65FAD cofactor analogCombined sources3
Nucleotide bindingi72 – 74FADCombined sources3
Nucleotide bindingi72 – 74FAD cofactor analogCombined sources3
Nucleotide bindingi175 – 176FADCombined sources2
Nucleotide bindingi175 – 176FAD cofactor analogCombined sources2
Nucleotide bindingi234 – 235FADCombined sources2
Nucleotide bindingi234 – 235FAD cofactor analogCombined sources2
Nucleotide bindingi239 – 242FADCombined sources4
Nucleotide bindingi239 – 242FAD cofactor analogCombined sources4
Nucleotide bindingi264 – 265AMPCombined sources2
Nucleotide bindingi273 – 277ADP analogCombined sources5
Nucleotide bindingi397 – 398FAD cofactor analogCombined sources2
Nucleotide bindingi398 – 399ADP analogCombined sources2

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

FADCombined sources, Flavoprotein, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.8.99.2. 414.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylylsulfate reductase, subunit A (AprA)Imported
Gene namesi
Ordered Locus Names:AF_1670Imported
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)Imported
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1670.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNRX-ray1.60A/C1-643[»]
1JNZX-ray2.50A/C1-643[»]
2FJAX-ray2.00A/C1-643[»]
2FJBX-ray1.70A/C1-643[»]
2FJDX-ray1.84A/C1-643[»]
2FJEX-ray1.80A/C1-643[»]
ProteinModelPortaliO28603.
SMRiO28603.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28603.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 263FAD_binding_2InterPro annotationAdd BLAST240
Domaini520 – 632Succ_DH_flav_CInterPro annotationAdd BLAST113

Phylogenomic databases

eggNOGiarCOG00573. Archaea.
COG1053. LUCA.
KOiK00394.
OMAiYDLGRHV.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR011803. AprA.
IPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR02061. aprA. 1 hit.

Sequencei

Sequence statusi: Complete.

O28603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYPKKYEL YKADEVPTEV VETDILIIGG GFSGCGAAYE AAYWAKLGGL
60 70 80 90 100
KVTLVEKAAV ERSGAVAQGL SAINTYIDLT GRSERQNTLE DYVRYVTLDM
110 120 130 140 150
MGLAREDLVA DYARHVDGTV HLFEKWGLPI WKTPDGKYVR EGQWQIMIHG
160 170 180 190 200
ESYKPIIAEA AKMAVGEENI YERVFIFELL KDKNDPNAVA GAVGFSVREP
210 220 230 240 250
KFYVFKAKAV ILATGGATLL FRPRSTGEAA GRTWYAIFDT GSGYYMGLKA
260 270 280 290 300
GAMLTQFEHR FIPFRFKDGY GPVGAWFLFF KCKAKNAYGE EYIKTRAAEL
310 320 330 340 350
EKYKPYGAAQ PIPTPLRNHQ VMLEIMDGNQ PIYMHTEEAL AELAGGDKKK
360 370 380 390 400
LKHIYEEAFE DFLDMTVSQA LLWACQNIDP QEQPSEAAPA EPYIMGSHSG
410 420 430 440 450
EAGFWVCGPE DLMPEEYAKL FPLKYNRMTT VKGLFAIGDC AGANPHKFSS
460 470 480 490 500
GSFTEGRIAA KAAVRFILEQ KPNPEIDDAV VEELKKKAYA PMERFMQYKD
510 520 530 540 550
LSTADDVNPE YILPWQGLVR LQKIMDEYAA GIATIYKTNE KMLQRALELL
560 570 580 590 600
AFLKEDLEKL AARDLHELMR AWELVHRVWT AEAHVRHMLF RKETRWPGYY
610 620 630 640
YRTDYPELND EEWKCFVCSK YDAEKDEWTF EKVPYVQVIE WSF
Length:643
Mass (Da):73,270
Last modified:January 1, 1998 - v1
Checksum:iA57091382F2E9F4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1.
PIRiE69458.
RefSeqiWP_010879166.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89579; AAB89579; AF_1670.
GeneIDi24795413.
KEGGiafu:AF_1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1.
PIRiE69458.
RefSeqiWP_010879166.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNRX-ray1.60A/C1-643[»]
1JNZX-ray2.50A/C1-643[»]
2FJAX-ray2.00A/C1-643[»]
2FJBX-ray1.70A/C1-643[»]
2FJDX-ray1.84A/C1-643[»]
2FJEX-ray1.80A/C1-643[»]
ProteinModelPortaliO28603.
SMRiO28603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89579; AAB89579; AF_1670.
GeneIDi24795413.
KEGGiafu:AF_1670.

Phylogenomic databases

eggNOGiarCOG00573. Archaea.
COG1053. LUCA.
KOiK00394.
OMAiYDLGRHV.

Enzyme and pathway databases

BRENDAi1.8.99.2. 414.

Miscellaneous databases

EvolutionaryTraceiO28603.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR011803. AprA.
IPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR02061. aprA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO28603_ARCFU
AccessioniPrimary (citable) accession number: O28603
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.