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O28603

- O28603_ARCFU

UniProt

O28603 - O28603_ARCFU

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Protein
Submitted name:

Adenylylsulfate reductase, subunit A (AprA)

Gene

AF_1670

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741ADPanalogImported
Binding sitei74 – 741SubstrateImported
Binding sitei95 – 951ADPanalogImported
Binding sitei95 – 951AMP
Binding sitei141 – 1411SubstrateImported
Binding sitei145 – 1451ADPanalogImported
Binding sitei145 – 1451AMP
Binding sitei214 – 2141FAD; via carbonyl oxygenImported
Binding sitei234 – 2341SubstrateImported
Binding sitei265 – 2651ADPanalogImported
Binding sitei265 – 2651FADcofactor analogImported
Binding sitei265 – 2651SubstrateImported
Binding sitei277 – 2771AMP
Binding sitei282 – 2821AMP; via carbonyl oxygen
Binding sitei292 – 2921AMP
Binding sitei317 – 3171ADPanalogImported
Binding sitei317 – 3171AMP
Binding sitei361 – 3611SubstrateImported
Binding sitei365 – 3651FADImported
Binding sitei397 – 3971FADImported
Active sitei398 – 3981Proton donor/acceptorImported
Binding sitei439 – 4391FAD; via amide nitrogenImported
Binding sitei439 – 4391FADcofactor analog; via amide nitrogenImported
Binding sitei449 – 4491FADImported
Binding sitei449 – 4491FADcofactor analogImported
Sitei449 – 4491Important for catalytic activityImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 332FADImported
Nucleotide bindingi32 – 332FADcofactor analogImported
Nucleotide bindingi56 – 572FADImported
Nucleotide bindingi56 – 572FADcofactor analogImported
Nucleotide bindingi63 – 653FADImported
Nucleotide bindingi63 – 653FADcofactor analogImported
Nucleotide bindingi72 – 743FADImported
Nucleotide bindingi72 – 743FADcofactor analogImported
Nucleotide bindingi175 – 1762FADImported
Nucleotide bindingi175 – 1762FADcofactor analogImported
Nucleotide bindingi234 – 2352FADImported
Nucleotide bindingi234 – 2352FADcofactor analogImported
Nucleotide bindingi239 – 2424FADImported
Nucleotide bindingi239 – 2424FADcofactor analogImported
Nucleotide bindingi264 – 2652AMP
Nucleotide bindingi273 – 2775ADPanalogImported
Nucleotide bindingi397 – 3982FADcofactor analogImported
Nucleotide bindingi398 – 3992ADPanalogImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

FADImported, Flavoprotein, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1704-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylylsulfate reductase, subunit A (AprA)Imported
Gene namesi
Ordered Locus Names:AF_1670Imported
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)Imported
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1670.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNRX-ray1.60A/C1-643[»]
1JNZX-ray2.50A/C1-643[»]
2FJAX-ray2.00A/C1-643[»]
2FJBX-ray1.70A/C1-643[»]
2FJDX-ray1.84A/C1-643[»]
2FJEX-ray1.80A/C1-643[»]
ProteinModelPortaliO28603.
SMRiO28603. Positions 2-643.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28603.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1053.
KOiK00394.
OMAiARKETRW.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR011803. AprA.
IPR003953. FAD_bind_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR02061. aprA. 1 hit.

Sequencei

Sequence statusi: Complete.

O28603-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVYYPKKYEL YKADEVPTEV VETDILIIGG GFSGCGAAYE AAYWAKLGGL
60 70 80 90 100
KVTLVEKAAV ERSGAVAQGL SAINTYIDLT GRSERQNTLE DYVRYVTLDM
110 120 130 140 150
MGLAREDLVA DYARHVDGTV HLFEKWGLPI WKTPDGKYVR EGQWQIMIHG
160 170 180 190 200
ESYKPIIAEA AKMAVGEENI YERVFIFELL KDKNDPNAVA GAVGFSVREP
210 220 230 240 250
KFYVFKAKAV ILATGGATLL FRPRSTGEAA GRTWYAIFDT GSGYYMGLKA
260 270 280 290 300
GAMLTQFEHR FIPFRFKDGY GPVGAWFLFF KCKAKNAYGE EYIKTRAAEL
310 320 330 340 350
EKYKPYGAAQ PIPTPLRNHQ VMLEIMDGNQ PIYMHTEEAL AELAGGDKKK
360 370 380 390 400
LKHIYEEAFE DFLDMTVSQA LLWACQNIDP QEQPSEAAPA EPYIMGSHSG
410 420 430 440 450
EAGFWVCGPE DLMPEEYAKL FPLKYNRMTT VKGLFAIGDC AGANPHKFSS
460 470 480 490 500
GSFTEGRIAA KAAVRFILEQ KPNPEIDDAV VEELKKKAYA PMERFMQYKD
510 520 530 540 550
LSTADDVNPE YILPWQGLVR LQKIMDEYAA GIATIYKTNE KMLQRALELL
560 570 580 590 600
AFLKEDLEKL AARDLHELMR AWELVHRVWT AEAHVRHMLF RKETRWPGYY
610 620 630 640
YRTDYPELND EEWKCFVCSK YDAEKDEWTF EKVPYVQVIE WSF
Length:643
Mass (Da):73,270
Last modified:January 1, 1998 - v1
Checksum:iA57091382F2E9F4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1.
PIRiE69458.
RefSeqiNP_070498.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89579; AAB89579; AF_1670.
GeneIDi1484893.
KEGGiafu:AF1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1 .
PIRi E69458.
RefSeqi NP_070498.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JNR X-ray 1.60 A/C 1-643 [» ]
1JNZ X-ray 2.50 A/C 1-643 [» ]
2FJA X-ray 2.00 A/C 1-643 [» ]
2FJB X-ray 1.70 A/C 1-643 [» ]
2FJD X-ray 1.84 A/C 1-643 [» ]
2FJE X-ray 1.80 A/C 1-643 [» ]
ProteinModelPortali O28603.
SMRi O28603. Positions 2-643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF1670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89579 ; AAB89579 ; AF_1670 .
GeneIDi 1484893.
KEGGi afu:AF1670.

Phylogenomic databases

eggNOGi COG1053.
KOi K00394.
OMAi ARKETRW.

Enzyme and pathway databases

BioCyci AFUL224325:GJBC-1704-MONOMER.

Miscellaneous databases

EvolutionaryTracei O28603.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR011803. AprA.
IPR003953. FAD_bind_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR02061. aprA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126Imported.
  2. "Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution."
    Fritz G., Roth A., Schiffer A., Buchert T., Bourenkov G., Bartunik H.D., Huber H., Stetter K.O., Kroneck P.M., Ermler U.
    Proc. Natl. Acad. Sci. U.S.A. 99:1836-1841(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH FAD, ACTIVE SITE.
  3. "Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states."
    Schiffer A., Fritz G., Kroneck P.M., Ermler U.
    Biochemistry 45:2960-2967(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ADPANALOG; AMP; FAD AND FADCOFACTOR ANALOG.

Entry informationi

Entry nameiO28603_ARCFU
AccessioniPrimary (citable) accession number: O28603
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3