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O28603

- O28603_ARCFU

UniProt

O28603 - O28603_ARCFU

Protein
Submitted name:

Adenylylsulfate reductase, subunit A (AprA)

Gene

AF_1670

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei74 – 741ADPanalogImported
    Binding sitei74 – 741SubstrateImported
    Binding sitei95 – 951ADPanalogImported
    Binding sitei95 – 951AMP
    Binding sitei141 – 1411SubstrateImported
    Binding sitei145 – 1451ADPanalogImported
    Binding sitei145 – 1451AMP
    Binding sitei214 – 2141FAD; via carbonyl oxygenImported
    Binding sitei234 – 2341SubstrateImported
    Binding sitei265 – 2651ADPanalogImported
    Binding sitei265 – 2651FADcofactor analogImported
    Binding sitei265 – 2651SubstrateImported
    Binding sitei277 – 2771AMP
    Binding sitei282 – 2821AMP; via carbonyl oxygen
    Binding sitei292 – 2921AMP
    Binding sitei317 – 3171ADPanalogImported
    Binding sitei317 – 3171AMP
    Binding sitei361 – 3611SubstrateImported
    Binding sitei365 – 3651FADImported
    Binding sitei397 – 3971FADImported
    Active sitei398 – 3981Proton donor/acceptorImported
    Binding sitei439 – 4391FAD; via amide nitrogenImported
    Binding sitei439 – 4391FADcofactor analog; via amide nitrogenImported
    Binding sitei449 – 4491FADImported
    Binding sitei449 – 4491FADcofactor analogImported
    Sitei449 – 4491Important for catalytic activityImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 332FADImported
    Nucleotide bindingi32 – 332FADcofactor analogImported
    Nucleotide bindingi56 – 572FADImported
    Nucleotide bindingi56 – 572FADcofactor analogImported
    Nucleotide bindingi63 – 653FADImported
    Nucleotide bindingi63 – 653FADcofactor analogImported
    Nucleotide bindingi72 – 743FADImported
    Nucleotide bindingi72 – 743FADcofactor analogImported
    Nucleotide bindingi175 – 1762FADImported
    Nucleotide bindingi175 – 1762FADcofactor analogImported
    Nucleotide bindingi234 – 2352FADImported
    Nucleotide bindingi234 – 2352FADcofactor analogImported
    Nucleotide bindingi239 – 2424FADImported
    Nucleotide bindingi239 – 2424FADcofactor analogImported
    Nucleotide bindingi264 – 2652AMP
    Nucleotide bindingi273 – 2775ADPanalogImported
    Nucleotide bindingi397 – 3982FADcofactor analogImported
    Nucleotide bindingi398 – 3992ADPanalogImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    FADImported, Flavoprotein, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciAFUL224325:GJBC-1704-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adenylylsulfate reductase, subunit A (AprA)Imported
    Gene namesi
    Ordered Locus Names:AF_1670Imported
    OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)Imported
    Taxonomic identifieri224325 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000002199: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi224325.AF1670.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JNRX-ray1.60A/C1-643[»]
    1JNZX-ray2.50A/C1-643[»]
    2FJAX-ray2.00A/C1-643[»]
    2FJBX-ray1.70A/C1-643[»]
    2FJDX-ray1.84A/C1-643[»]
    2FJEX-ray1.80A/C1-643[»]
    ProteinModelPortaliO28603.
    SMRiO28603. Positions 2-643.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO28603.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1053.
    KOiK00394.
    OMAiARKETRW.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR011803. AprA.
    IPR003953. FAD_bind_dom.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR02061. aprA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O28603-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVYYPKKYEL YKADEVPTEV VETDILIIGG GFSGCGAAYE AAYWAKLGGL    50
    KVTLVEKAAV ERSGAVAQGL SAINTYIDLT GRSERQNTLE DYVRYVTLDM 100
    MGLAREDLVA DYARHVDGTV HLFEKWGLPI WKTPDGKYVR EGQWQIMIHG 150
    ESYKPIIAEA AKMAVGEENI YERVFIFELL KDKNDPNAVA GAVGFSVREP 200
    KFYVFKAKAV ILATGGATLL FRPRSTGEAA GRTWYAIFDT GSGYYMGLKA 250
    GAMLTQFEHR FIPFRFKDGY GPVGAWFLFF KCKAKNAYGE EYIKTRAAEL 300
    EKYKPYGAAQ PIPTPLRNHQ VMLEIMDGNQ PIYMHTEEAL AELAGGDKKK 350
    LKHIYEEAFE DFLDMTVSQA LLWACQNIDP QEQPSEAAPA EPYIMGSHSG 400
    EAGFWVCGPE DLMPEEYAKL FPLKYNRMTT VKGLFAIGDC AGANPHKFSS 450
    GSFTEGRIAA KAAVRFILEQ KPNPEIDDAV VEELKKKAYA PMERFMQYKD 500
    LSTADDVNPE YILPWQGLVR LQKIMDEYAA GIATIYKTNE KMLQRALELL 550
    AFLKEDLEKL AARDLHELMR AWELVHRVWT AEAHVRHMLF RKETRWPGYY 600
    YRTDYPELND EEWKCFVCSK YDAEKDEWTF EKVPYVQVIE WSF 643
    Length:643
    Mass (Da):73,270
    Last modified:January 1, 1998 - v1
    Checksum:iA57091382F2E9F4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB89579.1.
    PIRiE69458.
    RefSeqiNP_070498.1. NC_000917.1.
    WP_010879166.1. NC_000917.1.

    Genome annotation databases

    EnsemblBacteriaiAAB89579; AAB89579; AF_1670.
    GeneIDi1484893.
    KEGGiafu:AF1670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB89579.1 .
    PIRi E69458.
    RefSeqi NP_070498.1. NC_000917.1.
    WP_010879166.1. NC_000917.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JNR X-ray 1.60 A/C 1-643 [» ]
    1JNZ X-ray 2.50 A/C 1-643 [» ]
    2FJA X-ray 2.00 A/C 1-643 [» ]
    2FJB X-ray 1.70 A/C 1-643 [» ]
    2FJD X-ray 1.84 A/C 1-643 [» ]
    2FJE X-ray 1.80 A/C 1-643 [» ]
    ProteinModelPortali O28603.
    SMRi O28603. Positions 2-643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224325.AF1670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB89579 ; AAB89579 ; AF_1670 .
    GeneIDi 1484893.
    KEGGi afu:AF1670.

    Phylogenomic databases

    eggNOGi COG1053.
    KOi K00394.
    OMAi ARKETRW.

    Enzyme and pathway databases

    BioCyci AFUL224325:GJBC-1704-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei O28603.

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR011803. AprA.
    IPR003953. FAD_bind_dom.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR02061. aprA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
      Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
      , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
      Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126Imported.
    2. "Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution."
      Fritz G., Roth A., Schiffer A., Buchert T., Bourenkov G., Bartunik H.D., Huber H., Stetter K.O., Kroneck P.M., Ermler U.
      Proc. Natl. Acad. Sci. U.S.A. 99:1836-1841(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH FAD, ACTIVE SITE.
    3. "Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states."
      Schiffer A., Fritz G., Kroneck P.M., Ermler U.
      Biochemistry 45:2960-2967(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ADPANALOG; AMP; FAD AND FADCOFACTOR ANALOG.

    Entry informationi

    Entry nameiO28603_ARCFU
    AccessioniPrimary (citable) accession number: O28603
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 1, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3