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O28603

- O28603_ARCFU

UniProt

O28603 - O28603_ARCFU

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Protein
Submitted name:

Adenylylsulfate reductase, subunit A (AprA)

Gene
AF_1670
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741ADP analogImported
Binding sitei74 – 741SubstrateImported
Binding sitei95 – 951ADP analogImported
Binding sitei95 – 951AMPImported
Binding sitei141 – 1411SubstrateImported
Binding sitei145 – 1451ADP analogImported
Binding sitei145 – 1451AMPImported
Binding sitei214 – 2141FAD; via carbonyl oxygen
Binding sitei234 – 2341SubstrateImported
Binding sitei265 – 2651ADP analogImported
Binding sitei265 – 2651FAD cofactor analogImported
Binding sitei265 – 2651SubstrateImported
Binding sitei277 – 2771AMPImported
Binding sitei282 – 2821AMP; via carbonyl oxygenImported
Binding sitei292 – 2921AMPImported
Binding sitei317 – 3171ADP analogImported
Binding sitei317 – 3171AMPImported
Binding sitei361 – 3611SubstrateImported
Binding sitei365 – 3651FADImported
Binding sitei397 – 3971FAD
Active sitei398 – 3981Proton donor/acceptorImported
Binding sitei439 – 4391FAD cofactor analog; via amide nitrogenImported
Binding sitei439 – 4391FAD; via amide nitrogen
Binding sitei449 – 4491FAD
Binding sitei449 – 4491FAD cofactor analogImported
Sitei449 – 4491Important for catalytic activityImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 332FAD
Nucleotide bindingi32 – 332FAD cofactor analogImported
Nucleotide bindingi56 – 572FAD
Nucleotide bindingi56 – 572FAD cofactor analogImported
Nucleotide bindingi63 – 653FAD
Nucleotide bindingi63 – 653FAD cofactor analogImported
Nucleotide bindingi72 – 743FAD
Nucleotide bindingi72 – 743FAD cofactor analogImported
Nucleotide bindingi175 – 1762FAD
Nucleotide bindingi175 – 1762FAD cofactor analogImported
Nucleotide bindingi234 – 2352FAD
Nucleotide bindingi234 – 2352FAD cofactor analogImported
Nucleotide bindingi239 – 2424FAD
Nucleotide bindingi239 – 2424FAD cofactor analogImported
Nucleotide bindingi264 – 2652AMPImported
Nucleotide bindingi273 – 2775ADP analogImported
Nucleotide bindingi397 – 3982FAD cofactor analogImported
Nucleotide bindingi398 – 3992ADP analogImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

FADImported, Flavoprotein, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1704-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylylsulfate reductase, subunit A (AprA)Imported
Gene namesi
Ordered Locus Names:AF_1670Imported
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)Imported
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1670.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JNRX-ray1.60A/C1-643[»]
1JNZX-ray2.50A/C1-643[»]
2FJAX-ray2.00A/C1-643[»]
2FJBX-ray1.70A/C1-643[»]
2FJDX-ray1.84A/C1-643[»]
2FJEX-ray1.80A/C1-643[»]
ProteinModelPortaliO28603.
SMRiO28603. Positions 2-643.

Miscellaneous databases

EvolutionaryTraceiO28603.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1053.
KOiK00394.
OMAiARKETRW.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR011803. AprA.
IPR003953. FAD_bind_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR02061. aprA. 1 hit.

Sequencei

Sequence statusi: Complete.

O28603-1 [UniParc]FASTAAdd to Basket

« Hide

MVYYPKKYEL YKADEVPTEV VETDILIIGG GFSGCGAAYE AAYWAKLGGL    50
KVTLVEKAAV ERSGAVAQGL SAINTYIDLT GRSERQNTLE DYVRYVTLDM 100
MGLAREDLVA DYARHVDGTV HLFEKWGLPI WKTPDGKYVR EGQWQIMIHG 150
ESYKPIIAEA AKMAVGEENI YERVFIFELL KDKNDPNAVA GAVGFSVREP 200
KFYVFKAKAV ILATGGATLL FRPRSTGEAA GRTWYAIFDT GSGYYMGLKA 250
GAMLTQFEHR FIPFRFKDGY GPVGAWFLFF KCKAKNAYGE EYIKTRAAEL 300
EKYKPYGAAQ PIPTPLRNHQ VMLEIMDGNQ PIYMHTEEAL AELAGGDKKK 350
LKHIYEEAFE DFLDMTVSQA LLWACQNIDP QEQPSEAAPA EPYIMGSHSG 400
EAGFWVCGPE DLMPEEYAKL FPLKYNRMTT VKGLFAIGDC AGANPHKFSS 450
GSFTEGRIAA KAAVRFILEQ KPNPEIDDAV VEELKKKAYA PMERFMQYKD 500
LSTADDVNPE YILPWQGLVR LQKIMDEYAA GIATIYKTNE KMLQRALELL 550
AFLKEDLEKL AARDLHELMR AWELVHRVWT AEAHVRHMLF RKETRWPGYY 600
YRTDYPELND EEWKCFVCSK YDAEKDEWTF EKVPYVQVIE WSF 643
Length:643
Mass (Da):73,270
Last modified:January 1, 1998 - v1
Checksum:iA57091382F2E9F4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1.
PIRiE69458.
RefSeqiNP_070498.1. NC_000917.1.
WP_010879166.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89579; AAB89579; AF_1670.
GeneIDi1484893.
KEGGiafu:AF1670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89579.1 .
PIRi E69458.
RefSeqi NP_070498.1. NC_000917.1.
WP_010879166.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JNR X-ray 1.60 A/C 1-643 [» ]
1JNZ X-ray 2.50 A/C 1-643 [» ]
2FJA X-ray 2.00 A/C 1-643 [» ]
2FJB X-ray 1.70 A/C 1-643 [» ]
2FJD X-ray 1.84 A/C 1-643 [» ]
2FJE X-ray 1.80 A/C 1-643 [» ]
ProteinModelPortali O28603.
SMRi O28603. Positions 2-643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF1670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89579 ; AAB89579 ; AF_1670 .
GeneIDi 1484893.
KEGGi afu:AF1670.

Phylogenomic databases

eggNOGi COG1053.
KOi K00394.
OMAi ARKETRW.

Enzyme and pathway databases

BioCyci AFUL224325:GJBC-1704-MONOMER.

Miscellaneous databases

EvolutionaryTracei O28603.

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR011803. AprA.
IPR003953. FAD_bind_dom.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR02061. aprA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.P., Clayton R.A., Tomb J., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B., Peterson S., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L., Utterback T., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
  2. "Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution."
    Fritz G., Roth A., Schiffer A., Buchert T., Bourenkov G., Bartunik H.D., Huber H., Stetter K.O., Kroneck P.M., Ermler U.
    Proc. Natl. Acad. Sci. U.S.A. 99:1836-1841(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH DEAMIDATED ASPARAGINE AND FAD, ACTIVE SITE.
  3. "Reaction mechanism of the iron-sulfur flavoenzyme adenosine-5'-phosphosulfate reductase based on the structural characterization of different enzymatic states."
    Schiffer A., Fritz G., Kroneck P.M., Ermler U.
    Biochemistry 45:2960-2967(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ADP ANALOG; AMP; FAD AND FAD COFACTOR ANALOG.

Entry informationi

Entry nameiO28603_ARCFU
AccessioniPrimary (citable) accession number: O28603
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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