O28580 (PUR5_ARCFU) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 70.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine cyclo-ligase EC=6.3.3.1 Alternative name(s): AIR synthase AIRS Phosphoribosyl-aminoimidazole synthetase | ||||
| Gene names |
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| Organism | Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) | ||||
| Taxonomic identifier | 224325 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus |
Protein attributes
| Sequence length | 329 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00741_A. |
| Sequence similarities | Belongs to the AIR synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 329 | 329 | Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A | PRO_0000148279 | |||
Sequences
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References
| [1] | "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. Venter J.C.Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000782 Genomic DNA. Translation: AAB89555.1. |
| PIR | D69461. |
| RefSeq | NP_070521.1. NC_000917.1. |
3D structure databases | |
| ProteinModelPortal | O28580. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1484916. |
| GenomeReviews | Gene locus AF_1693 in contig AE000782_GR. |
| KEGG | afu:AF1693. |
| NMPDR | fig|224325.1.peg.1682. |
| TIGR | AF_1693. |
Phylogenomic databases | |
| HOGENOM | HBG531222. |
| OMA | GIDMIAM. |
| PhylomeDB | O28580. |
| ProtClustDB | PRK05385. |
Enzyme and pathway databases | |
| BioCyc | AFUL224325:AF_1693-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00741_A. AIRS_A. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view] |
| KO | K01933. |
| Pfam | PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view] |
| SUPFAM | SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit. |
| TIGRFAMs | TIGR00878. PurM. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR5_ARCFU | ||||||||
| Accession | Primary (citable) accession number: O28580 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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