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O28580 (PUR5_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:AF_1693
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_A

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_A

Subcellular location

Cytoplasm By similarity HAMAP MF_00741_A.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_A
PRO_0000148279

Sequences

Sequence LengthMass (Da)Tools
O28580 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C9D291148AE3DD34

FASTA32936,209
        10         20         30         40         50         60 
MPKFDYAKAG VDIREEERAI KSLASVIKHV RSGFGRPILT SHYAGVIDCG DFGITITTDG 

        70         80         90        100        110        120 
VGSKILVAEK MRKFDTIGID CVAMNVNDLL AIGSEPLAMV DYIAIEKPDE WIMAEIAKGL 

       130        140        150        160        170        180 
EEGCRIANIT LLGGETATLP EIIRGFDLAG TAIGWVKKDA IITGEKIEEG DVIFAIPSSG 

       190        200        210        220        230        240 
IHSNGLTLAR KVVEAAGLSY HDKFGDKTIG EELLTPTRIY MEILDVLREC EVHGLAHITG 

       250        260        270        280        290        300 
SGLLKLKRLK NMKYVIDKPL KPQEIFRFIQ KLGEVEEAEM YRTFNMGMGF MVILPEDEAD 

       310        320 
KLKKLCEGRV VGYVEKGEGV YVKDLRLDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB89555.1.
PIRD69461.
RefSeqNP_070521.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28580.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1484916.
GenomeReviewsGene locus AF_1693 in contig AE000782_GR.
KEGGafu:AF1693.
NMPDRfig|224325.1.peg.1682.
TIGRAF_1693.

Phylogenomic databases

HOGENOMHBG531222.
OMAGIDMIAM.
PhylomeDBO28580.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycAFUL224325:AF_1693-MONOMER.

Family and domain databases

HAMAPMF_00741_A. AIRS_A.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
KOK01933.
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. PurM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_ARCFU
AccessionPrimary (citable) accession number: O28580
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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