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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:G1G17-1725-MONOMER
BRENDAi6.1.1.2 414

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:AF_1694
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367191 – 420Tryptophan--tRNA ligaseAdd BLAST420

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1694

Structurei

3D structure databases

ProteinModelPortaliO28579
SMRiO28579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi72 – 80"HIGH" region9
Motifi308 – 312"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z044X

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP

Sequencei

Sequence statusi: Complete.

O28579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVTPWEVEG VIDYSKLIEE FGMQPFSEVL PEIDNPHILM RRGAIFGHRD
60 70 80 90 100
YWRIIEAMQK KEPWAVMSGF MPSGLPHFGH KMTMDEIVWH QSAGGKAFVA
110 120 130 140 150
IADMEAHSVR GLSWEKTREL GMLYIKSIIA LGLREDAVIY FQSKSSHVKD
160 170 180 190 200
LAFELSAEVN FSELRAIYGF NSDTSLAKMF VTAIQAADIL HPQLSDFGGP
210 220 230 240 250
KPVVVPVGAD QDPHMRLTRD LAARISIFSF EPVEGGVRVR SRKGAEYLSS
260 270 280 290 300
LRDLEFDKKI YEEHMDIFGE AEEIERAVRK IEVEIGGFAF IPPSSTYHRF
310 320 330 340 350
TTGLTGGKMS SSKPESYISL LDPPEEGAKK VMKAFTGGRA TAEEQRRLGG
360 370 380 390 400
EPDRCVVFEL YSFHLIDSDE ELNQIEAECR EGRLLCGKCK KMAAELVKSF
410 420
LKEHQEKMEA VDLSNYTIIG
Length:420
Mass (Da):47,283
Last modified:January 1, 1998 - v1
Checksum:i9315152E2F172F24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89554.1
PIRiE69461
RefSeqiWP_010879190.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89554; AAB89554; AF_1694
GeneIDi1484917
KEGGiafu:AF_1694

Similar proteinsi

Entry informationi

Entry nameiSYW_ARCFU
AccessioniPrimary (citable) accession number: O28579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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