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O28579 (SYW_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:AF_1694
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136719

Regions

Motif72 – 809"HIGH" region HAMAP-Rule MF_00140
Motif308 – 3125"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
O28579 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9315152E2F172F24

FASTA42047,283
        10         20         30         40         50         60 
MNVTPWEVEG VIDYSKLIEE FGMQPFSEVL PEIDNPHILM RRGAIFGHRD YWRIIEAMQK 

        70         80         90        100        110        120 
KEPWAVMSGF MPSGLPHFGH KMTMDEIVWH QSAGGKAFVA IADMEAHSVR GLSWEKTREL 

       130        140        150        160        170        180 
GMLYIKSIIA LGLREDAVIY FQSKSSHVKD LAFELSAEVN FSELRAIYGF NSDTSLAKMF 

       190        200        210        220        230        240 
VTAIQAADIL HPQLSDFGGP KPVVVPVGAD QDPHMRLTRD LAARISIFSF EPVEGGVRVR 

       250        260        270        280        290        300 
SRKGAEYLSS LRDLEFDKKI YEEHMDIFGE AEEIERAVRK IEVEIGGFAF IPPSSTYHRF 

       310        320        330        340        350        360 
TTGLTGGKMS SSKPESYISL LDPPEEGAKK VMKAFTGGRA TAEEQRRLGG EPDRCVVFEL 

       370        380        390        400        410        420 
YSFHLIDSDE ELNQIEAECR EGRLLCGKCK KMAAELVKSF LKEHQEKMEA VDLSNYTIIG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89554.1.
PIRE69461.
RefSeqNP_070522.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB89554; AAB89554; AF_1694.
GeneID1484917.
KEGGafu:AF1694.

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMASIYHRFM.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1728-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
ProtoNetSearch...

Entry information

Entry nameSYW_ARCFU
AccessionPrimary (citable) accession number: O28579
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries