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O28579

- SYW_ARCFU

UniProt

O28579 - SYW_ARCFU

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Protein
Tryptophan--tRNA ligase
Gene
trpS, AF_1694
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:AF_1694
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1694.

Structurei

3D structure databases

ProteinModelPortaliO28579.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi72 – 809"HIGH" regionUniRule annotation
Motifi308 – 3125"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiSIYHRFM.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

O28579-1 [UniParc]FASTAAdd to Basket

« Hide

MNVTPWEVEG VIDYSKLIEE FGMQPFSEVL PEIDNPHILM RRGAIFGHRD    50
YWRIIEAMQK KEPWAVMSGF MPSGLPHFGH KMTMDEIVWH QSAGGKAFVA 100
IADMEAHSVR GLSWEKTREL GMLYIKSIIA LGLREDAVIY FQSKSSHVKD 150
LAFELSAEVN FSELRAIYGF NSDTSLAKMF VTAIQAADIL HPQLSDFGGP 200
KPVVVPVGAD QDPHMRLTRD LAARISIFSF EPVEGGVRVR SRKGAEYLSS 250
LRDLEFDKKI YEEHMDIFGE AEEIERAVRK IEVEIGGFAF IPPSSTYHRF 300
TTGLTGGKMS SSKPESYISL LDPPEEGAKK VMKAFTGGRA TAEEQRRLGG 350
EPDRCVVFEL YSFHLIDSDE ELNQIEAECR EGRLLCGKCK KMAAELVKSF 400
LKEHQEKMEA VDLSNYTIIG 420
Length:420
Mass (Da):47,283
Last modified:January 1, 1998 - v1
Checksum:i9315152E2F172F24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89554.1.
PIRiE69461.
RefSeqiNP_070522.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89554; AAB89554; AF_1694.
GeneIDi1484917.
KEGGiafu:AF1694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89554.1 .
PIRi E69461.
RefSeqi NP_070522.1. NC_000917.1.

3D structure databases

ProteinModelPortali O28579.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224325.AF1694.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89554 ; AAB89554 ; AF_1694 .
GeneIDi 1484917.
KEGGi afu:AF1694.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi SIYHRFM.

Enzyme and pathway databases

BioCyci AFUL224325:GJBC-1728-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 2 hits.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiSYW_ARCFU
AccessioniPrimary (citable) accession number: O28579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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