Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O28578 (PANE_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:AF_1695
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Putative 2-dehydropantoate 2-reductase
PRO_0000157322

Regions

Nucleotide binding10 – 156NADP By similarity

Sites

Active site1781Proton donor By similarity
Binding site981NADP; via amide nitrogen By similarity
Binding site981Substrate By similarity
Binding site1821Substrate By similarity
Binding site1861Substrate By similarity
Binding site2461Substrate By similarity
Binding site2581NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
O28578 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A0AFE175763A4184

FASTA29431,885
        10         20         30         40         50         60 
MRVQRVQIMG AGALGSLVGA LIQLAGYDVI FVARGKQLEA LKKGLRVSGL KNAELKVYCT 

        70         80         90        100        110        120 
SQPEDADITF VTVKAYDTET VAKKLAEVDA GVVCSLQNGV GNEEILAKYC RKVLGGVTTY 

       130        140        150        160        170        180 
GANLKDYGHV VYAGEGYTYV GEMDGRVSGE AEMVAEVLRD AGMRAEAVND IEFRIWAKAV 

       190        200        210        220        230        240 
VNAAINPITA ICRVKNGEVV RNPHLWEVAR AVADEGRQVM ARMGYEFDAA SEVRKVAEMT 

       250        260        270        280        290 
AENRSSMLQD LERGKRTEVE FINGAIVKKG EEFGIDCAVN RTLLNLVRGV ESGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89553.1.
PIRF69461.
RefSeqNP_070523.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28578.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1695.

Protocols and materials databases

DNASU1484918.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB89553; AAB89553; AF_1695.
GeneID1484918.
KEGGafu:AF1695.

Phylogenomic databases

eggNOGCOG1893.
KOK00077.
OMAIDDDRGE.
ProtClustDBPRK06522.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1729-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_ARCFU
AccessionPrimary (citable) accession number: O28578
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways