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O28578

- PANE_ARCFU

UniProt

O28578 - PANE_ARCFU

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Protein

Putative 2-dehydropantoate 2-reductase

Gene

AF_1695

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981NADP; via amide nitrogenBy similarity
Binding sitei98 – 981SubstrateBy similarity
Active sitei178 – 1781Proton donorBy similarity
Binding sitei182 – 1821SubstrateBy similarity
Binding sitei186 – 1861SubstrateBy similarity
Binding sitei246 – 2461SubstrateBy similarity
Binding sitei258 – 2581NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1729-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:AF_1695
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Putative 2-dehydropantoate 2-reductasePRO_0000157322Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1695.

Structurei

3D structure databases

ProteinModelPortaliO28578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
KOiK00077.
OMAiSQCHILL.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

O28578-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVQRVQIMG AGALGSLVGA LIQLAGYDVI FVARGKQLEA LKKGLRVSGL
60 70 80 90 100
KNAELKVYCT SQPEDADITF VTVKAYDTET VAKKLAEVDA GVVCSLQNGV
110 120 130 140 150
GNEEILAKYC RKVLGGVTTY GANLKDYGHV VYAGEGYTYV GEMDGRVSGE
160 170 180 190 200
AEMVAEVLRD AGMRAEAVND IEFRIWAKAV VNAAINPITA ICRVKNGEVV
210 220 230 240 250
RNPHLWEVAR AVADEGRQVM ARMGYEFDAA SEVRKVAEMT AENRSSMLQD
260 270 280 290
LERGKRTEVE FINGAIVKKG EEFGIDCAVN RTLLNLVRGV ESGL
Length:294
Mass (Da):31,885
Last modified:January 1, 1998 - v1
Checksum:iA0AFE175763A4184
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89553.1.
PIRiF69461.
RefSeqiNP_070523.1. NC_000917.1.
WP_010879191.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89553; AAB89553; AF_1695.
GeneIDi1484918.
KEGGiafu:AF1695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89553.1 .
PIRi F69461.
RefSeqi NP_070523.1. NC_000917.1.
WP_010879191.1. NC_000917.1.

3D structure databases

ProteinModelPortali O28578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF1695.

Protocols and materials databases

DNASUi 1484918.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89553 ; AAB89553 ; AF_1695 .
GeneIDi 1484918.
KEGGi afu:AF1695.

Phylogenomic databases

eggNOGi COG1893.
KOi K00077.
OMAi SQCHILL.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci AFUL224325:GJBC-1729-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiPANE_ARCFU
AccessioniPrimary (citable) accession number: O28578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3