DNA polymerase II large subunit - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

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O28552 (DP2L_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 66. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
DNA polymerase II large subunit
Short name=Pol II
EC=2.7.7.7

Gene names

Name:	polC
Ordered Locus Names:	AF_1722

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	1143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity. HAMAP MF_00324
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_00324 Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. HAMAP MF_00324
Subunit structure	Heterodimer of a large subunit and a small subunit By similarity.
Sequence similarities	Belongs to the archaeal DNA polymerase II family.

Ontologies

Keywords
Biological process	DNA replication
Ligand	DNA-binding
Molecular function	DNA-directed DNA polymerase Exonuclease Hydrolase Nuclease Nucleotidyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological process	DNA catabolic process Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW exonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1143

1143

DNA polymerase II large subunit HAMAP MF_00324

PRO_0000152573

Sequences

Sequence

Length

Mass (Da)

Tools

O28552 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7D874532600D851F
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FASTA

1,143

129,368

        10         20         30         40         50         60 
MDATLDRFFP LFESESNEDF WRIEEIRRYH ESLMVELDRI YRIAEAARKK GLDPELSVEI 

        70         80         90        100        110        120 
PIAKNMAERV EKLMNLQGLA KRIMELEEGG LSRELICFKV ADEIVEGKFG EMPKEEAIDK 

       130        140        150        160        170        180 
AVRTAVAIMT EGVVAAPIEG IARVRIDREN FLRVYYAGPI RSAGGTAQVI SVLVADYVRR 

       190        200        210        220        230        240 
KAEIGRYVPT EEEILRYCEE IPLYKKVANL QYLPSDEEIR LIVSNCPICI DGEPTESAEV 

       250        260        270        280        290        300 
SGYRNLPRVE TNRVRGGMAL VIAEGIALKA PKLKKMVDEV GIEGWEWLDA LIKGGGDSGS 

       310        320        330        340        350        360 
EEEKAVIKPK DKYLSDIVAG RPVLSHPSRK GGFRLRYGRA RNSGFATVGV NPATMYLLEF 

       370        380        390        400        410        420 
VAVGTQLKVE RPGKAGGVVP VSTIEGPTVR LKNGDVVKIN TLSEAKALKG EVAAILDLGE 

       430        440        450        460        470        480 
ILINYGDFLE NNHPLIPASY TYEWWIQEAE KAGLRGDYRK ISEEEALKLC DEFHVPLHPD 

       490        500        510        520        530        540 
YTYLWHDISV EDYRYLRNFV SDNGKIEGKH GKSVLLLPYD SRVKEILEAL LLEHKVRESF 

       550        560        570        580        590        600 
IVIETWRAFI RCLGLDEKLS KVSEVSGKDV LEIVNGISGI KVRPKALSRI GARMGRPEKA 

       610        620        630        640        650        660 
KERKMSPPPH ILFPVGMAGG NTRDIKNAIN YTKSYNAKKG EIEVEIAIRK CPQCGKETFW 

       670        680        690        700        710        720 
LKCDVCGELT EQLYYCPSCR MKNTSSVCES CGRECEGYMK RKVDLRELYE EAIANLGEYD 

       730        740        750        760        770        780 
SFDTIKGVKG MTSKTKIPER LEKGILRVKH GVFVFKDGTA RFDATDLPIT HFKPAEIGVS 

       790        800        810        820        830        840 
VEKLRELGYE RDYKGAELKN ENQIVELKPQ DVILPKSGAE YLLRVANFID DLLVKFYKME 

       850        860        870        880        890        900 
PFYNAKSVED LIGHLVIGLA PHTSAGVLGR IIGFSDVLAG YAHPYFHAAK RRNCDGDEDC 

       910        920        930        940        950        960 
FMLLLDGLLN FSRKFLPDKR GGQMDAPLVL TAIVDPREVD KEVHNMDIVE RYPLEFYEAT 

       970        980        990       1000       1010       1020 
MRFASPKEME DYVEKVKDRL KDESRFCGLF FTHDTENIAA GVKESAYKSL KTMQDKVYRQ 

      1030       1040       1050       1060       1070       1080 
MELARMIVAV DEHDVAERVI NVHFLPDIIG NLRAFSRQEF RCTRCNTKYR RIPLVGKCLK 

      1090       1100       1110       1120       1130       1140 
CGNKLTLTVH SSSIMKYLEL SKFLCENFNV SSYTKQRLML LEQEIKSMFE NGTEKQVSIS 


DFV

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References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.

Venter J.C.
Nature 390:364-370(1997) [PubMed: 9389475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB89529.1.
PIR	A69465.
RefSeq	NP_070550.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O28552.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1484945.
GenomeReviews	Gene locus AF_1722 in contig AE000782_GR.
KEGG	afu:AF1722.
NMPDR	fig\|224325.1.peg.1711.
TIGR	AF_1722.
Phylogenomic databases
HOGENOM	HBG497074.
OMA	NCDGDED.
ProtClustDB	PRK04023.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_1722-MONOMER.
Family and domain databases
HAMAP	MF_00324. DNApol_II_L_arch. [Tree]
InterPro	IPR004475. PolC_DP2. IPR016033. PolC_DP2_N. [Graphical view]
KO	K02322.
Pfam	PF03833. PolC_DP2. 1 hit. [Graphical view]
PIRSF	PIRSF016275. PolC_DP2. 1 hit.
TIGRFAMs	TIGR00354. PolC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DP2L_ARCFU

Accession

Primary (citable) accession number: O28552

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents