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Reviewed, UniProtKB/Swiss-Prot O28533 (PYRE_ARCFU)

Last modified February 9, 2010. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: AF_1741
OrganismArchaeoglobus fulgidus [Complete proteome] [HAMAP]
Taxonomic identifier2234 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110775

Regions

Region118 – 12695-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9315-phosphoribose 1-diphosphate By similarity
Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1221Orotate By similarity
Binding site1501Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
O28533-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 46D80741CC74FF19

FASTA17819,301
        10         20         30         40         50         60 
MVMLADALVK RMIEVGALKF GDFVLSSGKR SRVYVDVKLA STFPDILEMI SEGMAAKLKD 

        70         80         90        100        110        120 
LEFDRIACVE LGGVPIAVAL SLKMKKPLVI FRKEKKDYGI KGDRIGEVKE GEKVVVVEDV 

       130        140        150        160        170 
ITTGSSALSA ARRVEESGAS VAAIIAVVDR EESGRNFMSL LKLSDLIEAH DSIQPTES 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89504.1.
PIRD69467.
RefSeqNP_070569.1.

3D structure databases

SMRO28533. Positions 4-170.
ModBaseSearch...

Genome annotation databases

GeneID1484964.
GenomeReviewsGene locus AF_1741 in contig AE000782_GR.
KEGGafu:AF1741.
NMPDRfig|224325.1.peg.1730.
TIGRAF_1741.

Phylogenomic databases

HOGENOMHBG404341.
OMALSYPRIR.

Enzyme and pathway databases

BioCycAFUL224325:AF_1741-MONOMER.
BRENDA2.4.2.10. 7576.

Family and domain databases

HAMAPMF_01208_A. PyrE_A.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_ARCFU
AccessionPrimary (citable) accession number: O28533
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 9, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents