Myo-inositol-1-phosphate synthase (Ino1) - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Myo-inositol-1-phosphate synthase (Ino1) EMBL AAB89456.1

Gene names

Ordered Locus Names:

AF_1794

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	NAD PDB 1U1I Nucleotide-binding PDB 1U1I
Technical term	3D-structure PDB 1U1I Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol biosynthetic process Inferred from electronic annotation. Source: InterPro phospholipid biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol-3-phosphate synthase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

10 – 12

3

NAD PDB 1U1I

Nucleotide binding

57 – 59

3

NAD PDB 1U1I

Nucleotide binding

148 – 150

3

NAD PDB 1U1I

Sites

Binding site

99

1

NAD; via carbonyl oxygen PDB 1U1I

Binding site

185

1

NAD PDB 1U1I

Binding site

199

1

NAD PDB 1U1I

Binding site

228

1

NAD PDB 1U1I

Binding site

261

1

NAD PDB 1U1I

Binding site

274

1

NAD PDB 1U1I

Binding site

332

1

NAD PDB 1U1I

Sequences

Sequence

Length

Mass (Da)

Tools

O28480 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 387B0AFA946EBFDB
Show »

FASTA

392

43,713

        10         20         30         40         50         60 
MKVWLVGAYG IVSTTAMVGA RAIERGIAPK IGLVSELPHF EGIEKYAPFS FEFGGHEIRL 

        70         80         90        100        110        120 
LSNAYEAAKE HWELNRHFDR EILEAVKSDL EGIVARKGTA LNCGSGIKEL GDIKTLEGEG 

       130        140        150        160        170        180 
LSLAEMVSRI EEDIKSFADD ETVVINVAST EPLPNYSEEY HGSLEGFERM IDEDRKEYAS 

       190        200        210        220        230        240 
ASMLYAYAAL KLGLPYANFT PSPGSAIPAL KELAEKKGVP HAGNDGKTGE TLVKTTLAPM 

       250        260        270        280        290        300 
FAYRNMEVVG WMSYNILGDY DGKVLSARDN KESKVLSKDK VLEKMLGYSP YSITEIQYFP 

       310        320        330        340        350        360 
SLVDNKTAFD FVHFKGFLGK LMKFYFIWDA IDAIVAAPLI LDIARFLLFA KKKGVKGVVK 

       370        380        390 
EMAFFFKSPM DTNVINTHEQ FVVLKEWYSN LK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]	"Reaching for mechanistic consensus across life kingdoms: structure and insights into catalysis of the myo-inositol-1-phosphate synthase (mIPS) from Archaeoglobus fulgidus." Stieglitz K.A., Yang H., Roberts M.F., Stec B. Biochemistry 44:213-224(2005) [PubMed: 15628862] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH NAD.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000782 Genomic DNA. Translation: AAB89456.1.

PIR

A69474.

RefSeq

NP_070622.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1U1I	X-ray	1.90	A/B/C/D	1-392	[»]

ProteinModelPortal

O28480.

SMR

O28480. Positions 1-392.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1485017.

GenomeReviews

Gene locus AF_1794 in contig AE000782_GR.

KEGG

afu:AF1794.

NMPDR

fig|224325.1.peg.1783.

TIGR

AF_1794.

Phylogenomic databases

HOGENOM

HBG569232.

OMA

GNDGKTG.

ProtClustDB

CLSK782720.

Family and domain databases

InterPro

IPR002587. Myo-inos-1-P_Synthase.
IPR013021. Myo-inos-1-P_Synthase_GAPDH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.

KO

K01858.

PANTHER

PTHR11510. Inos-1-P_synth. 1 hit.

Pfam

PF01658. Inos-1-P_synth. 1 hit.
PF07994. NAD_binding_5. 1 hit.
[Graphical view]

PIRSF

PIRSF015578. Myoinos-ppht_syn. 1 hit.

ProtoNet

Search...

Entry information

Entry name

O28480_ARCFU

Accession

Primary (citable) accession number: O28480

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)