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O28440 (ASPD_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase

EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:AF_1838
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Probable L-aspartate dehydrogenase HAMAP-Rule MF_01265
PRO_0000144894

Sites

Active site1891 By similarity
Binding site1111NAD; via amide nitrogen By similarity
Binding site1621NAD By similarity

Secondary structure

........................................... 236
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O28440 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 29218ACC7F919F52

FASTA23626,208
        10         20         30         40         50         60 
MLVGLIGYGA IGKFLAEWLE RNGFEIAAIL DVRGEHEKMV RGIDEFLQRE MDVAVEAASQ 

        70         80         90        100        110        120 
QAVKDYAEKI LKAGIDLIVL STGAFADRDF LSRVREVCRK TGRRVYIASG AIGGLDAIFS 

       130        140        150        160        170        180 
ASELIEEIVL TTRKNWRQFG RKGVIFEGSA SEAAQKFPKN LNVAATLSIA SGKDVKVRLV 

       190        200        210        220        230 
ADEVEENIHE ILVRGEFGEM EIRVRNRPMR ENPKTSYLAA LSVTRILRNL KEGLVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89415.1.
PIRE69479.
RefSeqNP_070664.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DC1X-ray1.90A/B1-236[»]
ProteinModelPortalO28440.
SMRO28440. Positions 1-236.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1838.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB89415; AAB89415; AF_1838.
GeneID1485059.
KEGGafu:AF1838.

Phylogenomic databases

eggNOGCOG1712.
KOK06989.
OMAPKTSYLA.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1873-MONOMER.
SABIO-RKO28440.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR022487. Asp_DH_NAD_synth_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsTIGR03855. NAD_NadX. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO28440.

Entry information

Entry nameASPD_ARCFU
AccessionPrimary (citable) accession number: O28440
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways