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O28440 (ASPD_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase
EC=1.4.1.21
Gene names
Name:nadX
Ordered Locus Names:AF_1838
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity. HAMAP MF_01265

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Probable L-aspartate dehydrogenase HAMAP MF_01265
PRO_0000144894

Sites

Active site1891 By similarity
Binding site1111NAD; via amide nitrogen By similarity
Binding site1621NAD By similarity

Secondary structure

1 ........................................... 236
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O28440 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 29218ACC7F919F52

FASTA23626,208
        10         20         30         40         50         60 
MLVGLIGYGA IGKFLAEWLE RNGFEIAAIL DVRGEHEKMV RGIDEFLQRE MDVAVEAASQ 

        70         80         90        100        110        120 
QAVKDYAEKI LKAGIDLIVL STGAFADRDF LSRVREVCRK TGRRVYIASG AIGGLDAIFS 

       130        140        150        160        170        180 
ASELIEEIVL TTRKNWRQFG RKGVIFEGSA SEAAQKFPKN LNVAATLSIA SGKDVKVRLV 

       190        200        210        220        230 
ADEVEENIHE ILVRGEFGEM EIRVRNRPMR ENPKTSYLAA LSVTRILRNL KEGLVV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB89415.1.
PIRE69479.
RefSeqNP_070664.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DC1X-ray1.90A/B1-236[»]
ProteinModelPortalO28440.
SMRO28440. Positions 1-236.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1485059.
GenomeReviewsGene locus AF_1838 in contig AE000782_GR.
KEGGafu:AF1838.
NMPDRfig|224325.1.peg.1825.
TIGRAF_1838.

Phylogenomic databases

HOGENOMHBG649642.
OMAECAGHSA.

Enzyme and pathway databases

BioCycAFUL224325:AF_1838-MONOMER.

Family and domain databases

HAMAPMF_01265. NadX.
[Tree]
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR022487. Asp_DH_NAD_synth_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK06989.
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
TIGRFAMsTIGR03855. NAD_NadX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_ARCFU
AccessionPrimary (citable) accession number: O28440
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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