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Protein

CRISPR system Cmr subunit Cmr5

Gene

cmr5

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Part of the Cmr ribonucleoprotein complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein

Names & Taxonomyi

Protein namesi
Recommended name:
CRISPR system Cmr subunit Cmr5
Alternative name(s):
CRISPR type III-B/RAMP module-associated protein Cmr5
Gene namesi
Name:cmr5
Ordered Locus Names:AF_1862
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004184341 – 155CRISPR system Cmr subunit Cmr5Add BLAST155

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1862.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 24Combined sources22
Turni25 – 27Combined sources3
Helixi29 – 49Combined sources21
Helixi51 – 60Combined sources10
Helixi71 – 73Combined sources3
Helixi76 – 78Combined sources3
Beta strandi79 – 81Combined sources3
Helixi82 – 100Combined sources19
Helixi117 – 123Combined sources7
Helixi126 – 150Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OEBX-ray1.66A1-155[»]
3X1LX-ray2.10F/G1-155[»]
ProteinModelPortaliO28417.
SMRiO28417.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28417.

Family & Domainsi

Sequence similaritiesi

Belongs to the CRISPR system Cmr5 family.Curated

Phylogenomic databases

eggNOGiarCOG02654. Archaea.
ENOG410Z26E. LUCA.
KOiK19141.
OMAiNIDEVDY.

Family and domain databases

Gene3Di1.10.520.30. 1 hit.
InterProiIPR023101. AF1862-like_domain.
IPR010160. CRISPR-assoc_prot_Cmr5.
[Graphical view]
PfamiPF09701. Cas_Cmr5. 1 hit.
[Graphical view]
SUPFAMiSSF158568. SSF158568. 1 hit.
TIGRFAMsiTIGR01881. cas_Cmr5. 1 hit.

Sequencei

Sequence statusi: Complete.

O28417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIREIEQER ASFAFKVVSD IKDKYSQNKK VQGKYSSYAE KAPTIILNNG
60 70 80 90 100
LGATLAFFLS KLEKPIDDVD YKSINPESFG NAENIAYAFL YKHLSTWLAE
110 120 130 140 150
GNGKDSAFSG LTNGEDPLKY IMEKTAIDVA ISTEEALSIL NWIKKFAKAM

LEEEL
Length:155
Mass (Da):17,388
Last modified:January 1, 1998 - v1
Checksum:i3A367607DBC8497F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89393.1.
PIRiE69482.
RefSeqiWP_010879355.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89393; AAB89393; AF_1862.
GeneIDi24795603.
KEGGiafu:AF_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89393.1.
PIRiE69482.
RefSeqiWP_010879355.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OEBX-ray1.66A1-155[»]
3X1LX-ray2.10F/G1-155[»]
ProteinModelPortaliO28417.
SMRiO28417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89393; AAB89393; AF_1862.
GeneIDi24795603.
KEGGiafu:AF_1862.

Phylogenomic databases

eggNOGiarCOG02654. Archaea.
ENOG410Z26E. LUCA.
KOiK19141.
OMAiNIDEVDY.

Miscellaneous databases

EvolutionaryTraceiO28417.

Family and domain databases

Gene3Di1.10.520.30. 1 hit.
InterProiIPR023101. AF1862-like_domain.
IPR010160. CRISPR-assoc_prot_Cmr5.
[Graphical view]
PfamiPF09701. Cas_Cmr5. 1 hit.
[Graphical view]
SUPFAMiSSF158568. SSF158568. 1 hit.
TIGRFAMsiTIGR01881. cas_Cmr5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCMR5_ARCFU
AccessioniPrimary (citable) accession number: O28417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.