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Protein

Elongation factor 2

Gene

fusA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi93 – 97GTPBy similarity5
Nucleotide bindingi147 – 150GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 2
Short name:
EF-2
Gene namesi
Name:fusA
Synonyms:fus
Ordered Locus Names:AF_1894
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000910261 – 728Elongation factor 2Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594DiphthamideBy similarity1

Proteomic databases

PRIDEiO28385

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1894

Structurei

3D structure databases

ProteinModelPortaliO28385
SMRiO28385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 258tr-type GAdd BLAST241

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01559 Archaea
COG0480 LUCA
KOiK03234
OMAiEHLISGM
OrthoDBiPOG093Z00HF

Family and domain databases

Gene3Di3.30.230.10, 2 hits
HAMAPiMF_00054_A EF_G_EF_2_A, 1 hit
InterProiView protein in InterPro
IPR035647 EFG_III/V
IPR000640 EFG_V-like
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR004543 Transl_elong_EFG/EF2_arc
IPR005517 Transl_elong_EFG/EF2_IV
PfamiView protein in Pfam
PF00679 EFG_C, 1 hit
PF03764 EFG_IV, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SMARTiView protein in SMART
SM00838 EFG_C, 1 hit
SM00889 EFG_IV, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF54980 SSF54980, 2 hits
TIGRFAMsiTIGR00490 aEF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O28385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAKKVDKI KELMWKPKFI RNIGIVAHID HGKTTLSDNL LAGAGMISEE
60 70 80 90 100
LAGQQLYLDF DEQEQERGIT INAANVSMVH EYEGQDYLIN LIDTPGHVDF
110 120 130 140 150
GGDVTRAMRA VDGVIVVVDA VEGVMPQTET VLRQALKENV KPVLFVNKVD
160 170 180 190 200
RLIKELELTP QQMQERLIKV ITEVNKLIKA MRPDKYSEWK IDVANGSAAF
210 220 230 240 250
GSALYNWAVS VPSQKKTGIG FKEVYEHIKE GKVKELAKKS PLYQVVLDMV
260 270 280 290 300
IRHLPSPIEA QKERIAVIWK GDINSEVGKA MVNCDPKGPV ALMITKIVVE
310 320 330 340 350
PQAGEIAVGR LYSGTIRPGM ELYIVDRKAK NRIQTVGLYM GPRRVEVDEI
360 370 380 390 400
PAGNIVAVIG LKDAVAGSTC TTVENLTPFE SIKHYSEPVV TMAIEAKNPR
410 420 430 440 450
DLPKLIEVLR KLAKEDPTLH ITLNEETGEH LISGMGELHL EVKVEKIRRD
460 470 480 490 500
YKLDVITSPP IVVFRETVTG TSPVVEGKSP NKHNRFYIVV EPLPEKVIQM
510 520 530 540 550
FKEGVVDMKM DKKERRRLLQ EAGLTSEEAA GAEEYYEGNL FCDVTKGIQY
560 570 580 590 600
LNETMELILE GFREAMRAGP IAREPCMGIK VKLVDCKLHE DAVHRGPAQV
610 620 630 640 650
IPAVRSAIFA AILQAKPALL EPYQKIFITV PQDMMGAVTR EIQGRRGQIL
660 670 680 690 700
EMKTEGDMVT IIAKAPVKEM FGFAGAIRGA TSGKAIWSTE HAGFELVPQN
710 720
LFQEFVMEVR KRKGLKLEMP KPEDFVGL
Length:728
Mass (Da):81,136
Last modified:January 1, 1998 - v1
Checksum:i62BA963D6571AE9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89360.1
PIRiE69486
RefSeqiWP_010879387.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89360; AAB89360; AF_1894
GeneIDi24795638
KEGGiafu:AF_1894

Similar proteinsi

Entry informationi

Entry nameiEF2_ARCFU
AccessioniPrimary (citable) accession number: O28385
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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