O28362 (RNP1_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 1
Short name=RNase P component 1
EC=3.1.26.5

Alternative name(s):
aRpp29

Gene names

Name:	rnp1
Ordered Locus Names:	AF_1917

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. HAMAP-Rule MF_00754
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00754
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA cleavage Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: InterPro tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribonuclease MRP complex Inferred from electronic annotation. Source: InterPro ribonuclease P complex Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 102

102

Ribonuclease P protein component 1 HAMAP-Rule MF_00754

PRO_0000128425

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

102

Helix Strand Turn

Details...

Helix

6 – 12

7

Beta strand

19 – 24

6

Helix

28 – 30

3

Beta strand

34 – 40

7

Beta strand

42 – 57

16

Beta strand

62 – 67

6

Beta strand

70 – 75

6

Helix

76 – 78

3

Helix

83 – 96

14

Turn

97 – 99

3

Sequences

	Sequence		Length	Mass (Da)
	O28362 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: DF427B08A4543567	FASTA	102	11,806
	10 20 30 40 50 60 MRGRLQGVEL IARDWIGLMV EVVESPNHSE VGIKGEVVDE TQNTLKIMTE KGLKVVAKRG 70 80 90 100 RTFRVWYKGK IMRIKGDLIN FRPEDRIKRG LMMLKRAKGV WI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]	"NMR structure of an archaeal homologue of ribonuclease P protein Rpp29." Sidote D.J., Hoffman D.W. Biochemistry 42:13541-13550(2003) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000782 Genomic DNA. Translation: AAB89336.1.

PIR

D69489.

RefSeq

NP_070742.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PC0	NMR	-	A	17-77	[»]
1TS9	X-ray	1.70	A	1-102	[»]
1TSF	X-ray	1.70	A	1-102	[»]

DisProt

DP00382.

ProteinModelPortal

O28362.

SMR

O28362. Positions 5-102.

ModBase

Search...

Protein-protein interaction databases

STRING

224325.AF1917.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAB89336; AAB89336; AF_1917.

GeneID

1485140.

KEGG

afu:AF1917.

Phylogenomic databases

eggNOG

COG1588.

KO

K03538.

OMA

DLINFRP.

ProtClustDB

CLSK2747087.

Enzyme and pathway databases

BioCyc

AFUL224325:GJBC-1954-MONOMER.

Family and domain databases

Gene3D

2.30.30.210. 1 hit.

HAMAP

MF_00754. RNase_P_1.

InterPro

IPR002730. RNase_P/MRP_p29.
IPR023538. RNase_P_comp-1.
IPR023534. Rof/RNase_P-like.
[Graphical view]

Pfam

PF01868. UPF0086. 1 hit.
[Graphical view]

SMART

SM00538. POP4. 1 hit.
[Graphical view]

SUPFAM

SSF101744. RNase_P_Rpp29. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

O28362.

Entry information

Entry name

RNP1_ARCFU

Accession

Primary (citable) accession number: O28362

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program