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O28279 (SAHH_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:AF_2000
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Adenosylhomocysteinase HAMAP MF_00563
PRO_0000117001

Regions

Nucleotide binding139 – 1413NAD By similarity
Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding281 – 2833NAD By similarity

Sites

Binding site1131Substrate By similarity
Binding site1381Substrate By similarity
Binding site1681Substrate By similarity
Binding site1721Substrate By similarity
Binding site1731NAD By similarity
Binding site2251NAD By similarity
Binding site2601NAD By similarity
Binding site3271NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
O28279 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9B240D3E3E5C17C4

FASTA40545,395
        10         20         30         40         50         60 
MEGFRKIEWA ERYMKVLGKI REQFRKERPL EGFTVGMALH VEAKTAVLVR TLVDAGAEVA 

        70         80         90        100        110        120 
ITGCNPMSTQ DDVADALRES GIACYAKRGM DVEEYYEALR NVIRAEPDIV IDDGADLIFL 

       130        140        150        160        170        180 
LHGEMESYAE KVKGASEETT TGVIRLRAME REGVLKFPVI AVNDAYTKYL FDNRYGTGQS 

       190        200        210        220        230        240 
AIDGVIRATN LLMAGKIVVV AGYGWCGRGI AMRARGMGAS VVVTEVDEIR ALEAVMDGFR 

       250        260        270        280        290        300 
VMRMEDAAKI GDIFITATGN RDIIREEHIR LMKDGAILAN AGHFNVEIDI PALERMAKAK 

       310        320        330        340        350        360 
REARKYVTEY DLGDKRVYLL AEGRLVNLVA ADGHPVEVMD MSFANQALAA KYIAENWQKL 

       370        380        390        400 
ERKVYRLPEE LDRMVARMKL ESMGVEIDQL TEEQVRYLSD WRCGT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB89252.1.
PIRG69499.
RefSeqNP_070824.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28279.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1485225.
GenomeReviewsGene locus AF_2000 in contig AE000782_GR.
KEGGafu:AF2000.
NMPDRfig|224325.1.peg.1985.
TIGRAF_2000.

Phylogenomic databases

HOGENOMHBG352029.
OMAEGDIFIT.
PhylomeDBO28279.
ProtClustDBPRK05476.

Enzyme and pathway databases

BioCycAFUL224325:AF_2000-MONOMER.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_ARCFU
AccessionPrimary (citable) accession number: O28279
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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