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Protein

Probable L-aspartate decarboxylase

Gene

mfnA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.UniRule annotation

Catalytic activityi

L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00241.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:AF_2004
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470191 – 367Probable L-aspartate decarboxylaseAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi224325.AF2004.

Structurei

3D structure databases

ProteinModelPortaliO28275.
SMRiO28275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027. Archaea.
COG0076. LUCA.
KOiK18933.
OMAiDPHKMGL.
OrthoDBiPOG093Z06IK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01610. MfnA_decarbox. 1 hit.
InterProiView protein in InterPro
IPR020931. MfnA.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_dom1.
IPR015421. PyrdxlP-dep_Trfase_major.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Complete.

O28275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIIEELRAY REKDIPYSRV LSSMCTVPHP VAVEAHRMFI ETNLGDPGIF
60 70 80 90 100
RGTVELEAKL MRLIGDILHC ETPAGYICSG GTEANIQGIR AARNVQKKEN
110 120 130 140 150
PNIVIPKTAH FSFEKIGDIL GVKIKRAGVD EEYKVDVGQV EDLMDENTVA
160 170 180 190 200
IVGIAGTTEL GQIDPIVELS KLAEERQVEL HVDAAFGGLV IPFMDNPYPF
210 220 230 240 250
DFQNRGVSSI TIDPHKMGMA TIPAGGIIFR NESYLRALEV ETPYLTSKTQ
260 270 280 290 300
FTLTGTRPGT GVASAYAVLK SLGFEGMREV VKNCLKNTRI LVEEMRDLGF
310 320 330 340 350
EPVIEPVMNV VSFRTDEAER IKEELYRMRW VISTIREPKA IRFVVMPHVT
360
EEVIKNFISD FRKVLRR
Length:367
Mass (Da):41,171
Last modified:January 1, 1998 - v1
Checksum:i97FE8070AF75EE07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89250.1.
PIRiC69500.
RefSeqiWP_010879496.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89250; AAB89250; AF_2004.
GeneIDi24795749.
KEGGiafu:AF_2004.

Similar proteinsi

Entry informationi

Entry nameiMFNA_ARCFU
AccessioniPrimary (citable) accession number: O28275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome