O28275 (MFNA_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-tyrosine decarboxylase
Short name=TDC
EC=4.1.1.25

Gene names

Name:	mfnA
Ordered Locus Names:	AF_2004

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine By similarity. HAMAP-Rule MF_01610
Catalytic activity	L-tyrosine = tyramine + CO2. HAMAP-Rule MF_01610
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tyrosine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP tyrosine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	L-tyrosine decarboxylase HAMAP-Rule MF_01610		PRO_0000147019
Amino acid modifications
	Modified residue	216	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O28275 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 97FE8070AF75EE07	FASTA	367	41,171
	10 20 30 40 50 60 MDIIEELRAY REKDIPYSRV LSSMCTVPHP VAVEAHRMFI ETNLGDPGIF RGTVELEAKL 70 80 90 100 110 120 MRLIGDILHC ETPAGYICSG GTEANIQGIR AARNVQKKEN PNIVIPKTAH FSFEKIGDIL 130 140 150 160 170 180 GVKIKRAGVD EEYKVDVGQV EDLMDENTVA IVGIAGTTEL GQIDPIVELS KLAEERQVEL 190 200 210 220 230 240 HVDAAFGGLV IPFMDNPYPF DFQNRGVSSI TIDPHKMGMA TIPAGGIIFR NESYLRALEV 250 260 270 280 290 300 ETPYLTSKTQ FTLTGTRPGT GVASAYAVLK SLGFEGMREV VKNCLKNTRI LVEEMRDLGF 310 320 330 340 350 360 EPVIEPVMNV VSFRTDEAER IKEELYRMRW VISTIREPKA IRFVVMPHVT EEVIKNFISD FRKVLRR

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB89250.1.
PIR	C69500.
RefSeq	NP_070828.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O28275.
ModBase	Search...
Protein-protein interaction databases
STRING	224325.AF2004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB89250; AAB89250; AF_2004.
GeneID	1485229.
KEGG	afu:AF2004.
Phylogenomic databases
eggNOG	COG0076.
KO	K01592.
OMA	DAPYLTE.
ProtClustDB	PRK13520.
Enzyme and pathway databases
BioCyc	AFUL224325:GJBC-2044-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAP	MF_01610. Tyr_decarbox.
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. IPR020931. Tyr_deCO2ase. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MFNA_ARCFU

Accession

Primary (citable) accession number: O28275

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program