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O28237 (PYRH_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uridylate kinase
Short name=UK
EC=2.7.4.22
Alternative name(s):
Uridine monophosphate kinase
Short name=UMP kinase
Short name=UMPK
Gene names
Name:pyrH
Ordered Locus Names:AF_2042
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of UMP to UDP By similarity. HAMAP MF_01220_A

Catalytic activity

ATP + UMP = ADP + UDP. HAMAP MF_01220_A

Enzyme regulation

Inhibited by UTP By similarity. HAMAP MF_01220_A

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. HAMAP MF_01220_A

Subunit structure

Homohexamer By similarity. HAMAP MF_01220_A

Subcellular location

Cytoplasm By similarity HAMAP MF_01220_A.

Sequence similarities

Belongs to the UMP kinase family.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular amino acid biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

UMP kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Uridylate kinase HAMAP MF_01220_A
PRO_0000143914

Regions

Nucleotide binding9 – 102ATP By similarity
Nucleotide binding110 – 1167UMP By similarity

Sites

Binding site411UMP; via amide nitrogen By similarity
Binding site421ATP; via amide nitrogen By similarity
Binding site461ATP By similarity
Binding site631UMP By similarity
Binding site1361ATP By similarity
Binding site1371ATP By similarity
Binding site1421ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1451ATP By similarity

Secondary structure

1 .................................... 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O28237 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 751B894ED5261B91

FASTA21923,398
        10         20         30         40         50         60 
MKVVLSLGGS VLSNESEKIR EFAKTIESVA QQNQVFVVVG GGKLAREYIK RARELGASET 

        70         80         90        100        110        120 
FCDYIGIAAT RLNAMLLISA IPSAAKKVPV DFMEAEELSK LYRVVVMGGT FPGHTTDATA 

       130        140        150        160        170        180 
ALLAEFIKAD VFINATNVDG VYSADPKSDT SAVKYDRLSP QQLVEIVSRS SAKAGTNVVI 

       190        200        210 
DLLAAKIIER SKIKTYVILG TPENIMKAVK GEAVGTVIA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB89213.1.
PIRA69505.
RefSeqNP_070866.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IJ9X-ray2.90A/B1-219[»]
ProteinModelPortalO28237.
SMRO28237. Positions 1-219.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1485269.
GenomeReviewsGene locus AF_2042 in contig AE000782_GR.
KEGGafu:AF2042.
NMPDRfig|224325.1.peg.2027.
TIGRAF_2042.

Phylogenomic databases

HOGENOMHBG497552.
OMATRANAML.
ProtClustDBCLSK2747149.

Enzyme and pathway databases

BioCycAFUL224325:AF_2042-MONOMER.

Family and domain databases

HAMAPMF_01220_A. PyrH_A.
[Tree]
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR011818. Uridylate_kinase_arch/spir.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KOK09903.
PANTHERPTHR26059. PTHR26059. 1 hit.
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMSSF53633. Aa_kinase. 1 hit.
TIGRFAMsTIGR02076. PyrH_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRH_ARCFU
AccessionPrimary (citable) accession number: O28237
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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