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Protein

Uridylate kinase

Gene

pyrH

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Enzyme regulationi

Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41UMP; via amide nitrogenUniRule annotation1
Binding sitei42ATP; via amide nitrogenUniRule annotation1
Binding sitei46ATPUniRule annotation1
Binding sitei63UMPUniRule annotation1
Binding sitei136ATPUniRule annotation1
Binding sitei137ATPUniRule annotation1
Binding sitei142ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei145ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi110 – 116UMPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00275.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:AF_2042
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439141 – 219Uridylate kinaseAdd BLAST219

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF2042.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Turni11 – 14Combined sources4
Helixi16 – 32Combined sources17
Beta strandi33 – 39Combined sources7
Helixi42 – 54Combined sources13
Helixi59 – 80Combined sources22
Helixi92 – 99Combined sources8
Beta strandi103 – 107Combined sources5
Beta strandi111 – 114Combined sources4
Helixi117 – 126Combined sources10
Beta strandi130 – 140Combined sources11
Beta strandi147 – 151Combined sources5
Beta strandi156 – 158Combined sources3
Helixi160 – 166Combined sources7
Helixi182 – 191Combined sources10
Beta strandi195 – 199Combined sources5
Helixi202 – 209Combined sources8
Beta strandi215 – 218Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IJ9X-ray2.90A/B1-219[»]
ProteinModelPortaliO28237.
SMRiO28237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28237.

Family & Domainsi

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00858. Archaea.
COG0528. LUCA.
KOiK09903.
OMAiYIGIHIT.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_01220_A. PyrH_A. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR011818. Uridylate_kinase_arch/spir.
[Graphical view]
PANTHERiPTHR21499:SF23. PTHR21499:SF23. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR02076. pyrH_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O28237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVLSLGGS VLSNESEKIR EFAKTIESVA QQNQVFVVVG GGKLAREYIK
60 70 80 90 100
RARELGASET FCDYIGIAAT RLNAMLLISA IPSAAKKVPV DFMEAEELSK
110 120 130 140 150
LYRVVVMGGT FPGHTTDATA ALLAEFIKAD VFINATNVDG VYSADPKSDT
160 170 180 190 200
SAVKYDRLSP QQLVEIVSRS SAKAGTNVVI DLLAAKIIER SKIKTYVILG
210
TPENIMKAVK GEAVGTVIA
Length:219
Mass (Da):23,398
Last modified:January 1, 1998 - v1
Checksum:i751B894ED5261B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89213.1.
PIRiA69505.
RefSeqiWP_010879534.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89213; AAB89213; AF_2042.
GeneIDi24795791.
KEGGiafu:AF_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89213.1.
PIRiA69505.
RefSeqiWP_010879534.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IJ9X-ray2.90A/B1-219[»]
ProteinModelPortaliO28237.
SMRiO28237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89213; AAB89213; AF_2042.
GeneIDi24795791.
KEGGiafu:AF_2042.

Phylogenomic databases

eggNOGiarCOG00858. Archaea.
COG0528. LUCA.
KOiK09903.
OMAiYIGIHIT.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00275.

Miscellaneous databases

EvolutionaryTraceiO28237.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_01220_A. PyrH_A. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR011818. Uridylate_kinase_arch/spir.
[Graphical view]
PANTHERiPTHR21499:SF23. PTHR21499:SF23. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR02076. pyrH_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRH_ARCFU
AccessioniPrimary (citable) accession number: O28237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.