Reviewed, UniProtKB/Swiss-Prot O28234 (PSD_ARCFU)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	AF_2045

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029819
	Chain	159 – 195	37	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029820
Sites
	Site	158 – 159	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	159	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O28234-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3FFBE5984581E5C3	FASTA	195	21,558
	10 20 30 40 50 60 MIERSGYGII AASLLLSAVA YLLHPLISAL FVGFALFTAY FFRDPERKIG EGVVSPADGR 70 80 90 100 110 120 IDYLEGRRLE IFMSPFDCHI NRAPWGGKVL SVKFIEGSTP PAFIRKSGVR TNEILIETEH 130 140 150 160 170 180 GVFRVLQMAG IFARRIVSYV SEGDVVKKGQ KIGMIRFGSR VVLEVPEGFR FVRGVGEKVK 190 AGETVALRDE SFQGS

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000782 Genomic DNA. Translation: AAB89201.1.
PIR	D69505.
RefSeq	NP_070869.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1485272.
GenomeReviews	Gene locus AF_2045 in contig AE000782_GR.
KEGG	afu:AF2045.
NMPDR	fig|224325.1.peg.2030.
TIGR	AF_2045.
Phylogenomic databases
HOGENOM	O28234.
OMA	HVNRAPL.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_2045-MON.
BRENDA	4.1.1.65. 7576.
Family and domain databases
HAMAP	MF_00664. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_ARCFU

Accession

Primary (citable) accession number: O28234

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)