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O28204 (THIM_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:AF_2075
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156967

Sites

Binding site491Substrate; via amide nitrogen By similarity
Binding site1241ATP By similarity
Binding site1681ATP By similarity
Binding site1951Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
O28204 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 3A816BB80B5D6158

FASTA26828,571
        10         20         30         40         50         60 
MHLQRLKEEL ERDIARIAEF KPVVHHITNY VAMNDSANIT IAIGASPIMS FAHGEIDELV 

        70         80         90        100        110        120 
SIASSLLINI GTLDEYIIQA VMLAVKSAKS KGVPVLLDPV GSGATKLRTS TALSVAEEGV 

       130        140        150        160        170        180 
DVIKGNQGEI LSLLRKEGVV RGVDSKVTAE AADVKEVARK FGLVVVATGK EDLISDGRSV 

       190        200        210        220        230        240 
YVMRNGTEML GRITASGCML GSVIASFMAV QKDFLLASLE GLACYNVAGE LAAEKSSGTA 

       250        260 
SFRSNLIDEI SKITAEKVIE RLNLERVV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89174.1.
PIRB69509.
RefSeqNP_070899.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF2075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB89174; AAB89174; AF_2075.
GeneID1485302.
KEGGafu:AF2075.

Phylogenomic databases

eggNOGCOG2145.
KOK00878.
OMASPVMAHA.
ProtClustDBPRK09355.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-2117-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_ARCFU
AccessionPrimary (citable) accession number: O28204
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways