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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
Ordered Locus Names:AF_2206
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001563181 – 148Phosphopantetheine adenylyltransferaseAdd BLAST148

Interactioni

Protein-protein interaction databases

STRINGi224325.AF2206.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi14 – 27Combined sources14
Beta strandi31 – 36Combined sources6
Helixi38 – 44Combined sources7
Helixi51 – 66Combined sources16
Beta strandi71 – 75Combined sources5
Turni78 – 84Combined sources7
Beta strandi88 – 92Combined sources5
Turni94 – 96Combined sources3
Helixi97 – 110Combined sources14
Beta strandi116 – 121Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DO8X-ray1.60A/B1-148[»]
ProteinModelPortaliO28077.
SMRiO28077.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28077.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic CoaD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01223. Archaea.
COG1019. LUCA.
KOiK02201.
OMAiEIMVIND.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00647. PPAT_arch. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR023540. Ppantetheine_adenylTrfase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

O28077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVALGGTFE PLHEGHKKLI DVAIKLGGRD ITIGVTSDRM ARARIRSVLP
60 70 80 90 100
FAIRAENVKR YVMRKYGFEP EIVKITNPYG KTLDVDFEYL VVSPETYEMA
110 120 130 140
LKINQKREEL GKRKITIVKV DWMMAEDGKP ISSTRIKRGE IDRYGGII
Length:148
Mass (Da):16,883
Last modified:January 1, 1998 - v1
Checksum:i27AD2A950588D9B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89047.1.
PIRiF69525.
RefSeqiWP_010879695.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89047; AAB89047; AF_2206.
GeneIDi24795955.
KEGGiafu:AF_2206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89047.1.
PIRiF69525.
RefSeqiWP_010879695.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DO8X-ray1.60A/B1-148[»]
ProteinModelPortaliO28077.
SMRiO28077.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2206.

Protocols and materials databases

DNASUi1485435.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89047; AAB89047; AF_2206.
GeneIDi24795955.
KEGGiafu:AF_2206.

Phylogenomic databases

eggNOGiarCOG01223. Archaea.
COG1019. LUCA.
KOiK02201.
OMAiEIMVIND.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Miscellaneous databases

EvolutionaryTraceiO28077.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00647. PPAT_arch. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR023540. Ppantetheine_adenylTrfase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAD_ARCFU
AccessioniPrimary (citable) accession number: O28077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.