Reviewed, UniProtKB/Swiss-Prot O28077 (COAD_ARCFU)

Names and origin

Protein names

Recommended name:
    Phosphopantetheine adenylyltransferase
    EC=2.7.7.3
Alternative name(s):
    Pantetheine-phosphate adenylyltransferase
      Short name=PPAT
    Dephospho-CoA pyrophosphorylase

Gene names

Name:	coaD
Ordered Locus Names:	AF_2206

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity.
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00647
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00647
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic coaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 148

148

Phosphopantetheine adenylyltransferase HAMAP MF_00647

PRO_0000156318

Secondary structure

1

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148

Helix Strand Turn

Details...

Helix

17 – 25

9

Beta strand

31 – 33

3

Helix

38 – 44

7

Helix

51 – 65

15

Beta strand

71 – 75

5

Turn

82 – 84

3

Beta strand

88 – 92

5

Turn

94 – 96

3

Helix

97 – 109

13

Beta strand

116 – 121

6

Sequences

	Sequence		Length	Mass (Da)
	O28077-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 27AD2A950588D9B5	FASTA	148	16,883
	10 20 30 40 50 60 MKVALGGTFE PLHEGHKKLI DVAIKLGGRD ITIGVTSDRM ARARIRSVLP FAIRAENVKR 70 80 90 100 110 120 YVMRKYGFEP EIVKITNPYG KTLDVDFEYL VVSPETYEMA LKINQKREEL GKRKITIVKV 130 140 DWMMAEDGKP ISSTRIKRGE IDRYGGII

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000782 Genomic DNA. Translation: AAB89047.1.

PIR

F69525.

RefSeq

NP_071031.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DO8	X-ray	1.60	A/B	1-148	[»]

ModBase

Search...

Genome annotation databases

GeneID

1485435.

GenomeReviews

Gene locus AF_2206 in contig AE000782_GR.

KEGG

afu:AF2206.

NMPDR

fig|224325.1.peg.2192.

TIGR

AF_2206.

Phylogenomic databases

HOGENOM

O28077.

OMA

ISTTRIR.

Enzyme and pathway databases

BioCyc

AFUL224325:AF_2206-MON.

BRENDA

2.7.7.3. 7576.

Family and domain databases

HAMAP

MF_00647.
[Tree]

InterPro

IPR004821. Cyt_trans_rel.
IPR004820. Cytidylyltransf.
[Graphical view]

PANTHER

PTHR10695. Depp_CoAkinase. 1 hit.

Pfam

PF01467. CTP_transf_2. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00125. cyt_tran_rel. 1 hit.

ProtoNet

Search...

Entry information

Entry name

COAD_ARCFU

Accession

Primary (citable) accession number: O28077

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)