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O28076

- FTR_ARCFU

UniProt

O28076 - FTR_ARCFU

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Protein

Formylmethanofuran--tetrahydromethanopterin formyltransferase

Gene

ftr

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H4MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H4MPT).1 Publication

Catalytic activityi

Formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin.

Pathwayi

GO - Molecular functioni

  1. formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate oxidation Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

One-carbon metabolism

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-2252-MONOMER.
UniPathwayiUPA00701.

Names & Taxonomyi

Protein namesi
Recommended name:
Formylmethanofuran--tetrahydromethanopterin formyltransferase (EC:2.3.1.101)
Alternative name(s):
H4MPT formyltransferase
Gene namesi
Name:ftr
Ordered Locus Names:AF_2207
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Formylmethanofuran--tetrahydromethanopterin formyltransferasePRO_0000138115Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224325.AF2207.

Structurei

Secondary structure

1
297
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Beta strandi12 – 2615Combined sources
Helixi30 – 4112Combined sources
Turni47 – 493Combined sources
Beta strandi53 – 608Combined sources
Helixi62 – 643Combined sources
Beta strandi71 – 8010Combined sources
Helixi81 – 9515Combined sources
Turni96 – 983Combined sources
Beta strandi103 – 1075Combined sources
Beta strandi112 – 1154Combined sources
Helixi117 – 1215Combined sources
Helixi122 – 1254Combined sources
Beta strandi130 – 1345Combined sources
Beta strandi137 – 1437Combined sources
Beta strandi145 – 1539Combined sources
Beta strandi155 – 17218Combined sources
Helixi173 – 18816Combined sources
Helixi198 – 2003Combined sources
Beta strandi202 – 2043Combined sources
Beta strandi207 – 2093Combined sources
Helixi222 – 2243Combined sources
Helixi226 – 2283Combined sources
Helixi229 – 2324Combined sources
Beta strandi243 – 25311Combined sources
Helixi254 – 26815Combined sources
Beta strandi274 – 2785Combined sources
Turni283 – 2853Combined sources
Beta strandi288 – 2925Combined sources
Helixi293 – 2953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M5HX-ray2.00A/B/C/D/E/F/G/H1-297[»]
ProteinModelPortaliO28076.
SMRiO28076. Positions 1-297.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28076.

Family & Domainsi

Sequence similaritiesi

Belongs to the FTR family.Curated

Phylogenomic databases

eggNOGiCOG2037.
KOiK00672.
OMAiLERIGQC.

Family and domain databases

Gene3Di3.30.70.520. 2 hits.
HAMAPiMF_00579. FTR.
InterProiIPR014053. ForMFR_H4MPT_ForTrfase.
IPR002770. ForMFR_H4MPT_ForTrfase_C.
IPR023447. ForMFR_H4MPT_ForTrfase_fd-like.
IPR022667. ForMFR_H4MPT_ForTrfase_N.
[Graphical view]
PfamiPF01913. FTR. 1 hit.
PF02741. FTR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006414. Ftr_formyl_trnsf. 1 hit.
SUPFAMiSSF55112. SSF55112. 2 hits.
TIGRFAMsiTIGR03119. one_C_fhcD. 1 hit.

Sequencei

Sequence statusi: Complete.

O28076-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVNGVEVEE TFAEAFDIKI ARVLITGYDY YWAWVAANEA TGFGTSVIMC
60 70 80 90 100
PAEAGIEIKA KPSETPDGRP GYYIQICHMS KKGLEEQLLA RLGQCVLTAP
110 120 130 140 150
TTAVFNGLPD AEEKFDTGFK LKFFADGYEK EVEVGGRKCW AVPMMEGDFI
160 170 180 190 200
IENDIGYTNG IAGGNFFIMA ETQPSALAAA KAAVDAISDV EGVITPFPGG
210 220 230 240 250
IVASGSKVGA NKYKFLKAST NEKFAPSIRD QVEGTQIPEG VKAVYEIVIN
260 270 280 290
GLNADAIKEA TRVGILAATK IPGVVKITAG NYGGKLGKHI INLNELF
Length:297
Mass (Da):31,762
Last modified:January 1, 1998 - v1
Checksum:i1466551AFFE97E4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321Missing AA sequence (PubMed:1483480)Curated
Sequence conflicti32 – 321Missing AA sequence (PubMed:8481089)Curated
Sequence conflicti34 – 341W → I AA sequence (PubMed:1483480)Curated
Sequence conflicti34 – 341W → I AA sequence (PubMed:8481089)Curated
Sequence conflicti43 – 431F → T AA sequence (PubMed:8481089)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89046.1.
PIRiG69525.
RefSeqiNP_071032.1. NC_000917.1.
WP_010879696.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89046; AAB89046; AF_2207.
GeneIDi1485436.
KEGGiafu:AF2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89046.1 .
PIRi G69525.
RefSeqi NP_071032.1. NC_000917.1.
WP_010879696.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M5H X-ray 2.00 A/B/C/D/E/F/G/H 1-297 [» ]
ProteinModelPortali O28076.
SMRi O28076. Positions 1-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF2207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89046 ; AAB89046 ; AF_2207 .
GeneIDi 1485436.
KEGGi afu:AF2207.

Phylogenomic databases

eggNOGi COG2037.
KOi K00672.
OMAi LERIGQC.

Enzyme and pathway databases

UniPathwayi UPA00701 .
BioCyci AFUL224325:GJBC-2252-MONOMER.

Miscellaneous databases

EvolutionaryTracei O28076.

Family and domain databases

Gene3Di 3.30.70.520. 2 hits.
HAMAPi MF_00579. FTR.
InterProi IPR014053. ForMFR_H4MPT_ForTrfase.
IPR002770. ForMFR_H4MPT_ForTrfase_C.
IPR023447. ForMFR_H4MPT_ForTrfase_fd-like.
IPR022667. ForMFR_H4MPT_ForTrfase_N.
[Graphical view ]
Pfami PF01913. FTR. 1 hit.
PF02741. FTR_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006414. Ftr_formyl_trnsf. 1 hit.
SUPFAMi SSF55112. SSF55112. 2 hits.
TIGRFAMsi TIGR03119. one_C_fhcD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
  2. "Salt dependence, kinetic properties and catalytic mechanism of N-formylmethanofuran:tetrahydromethanopterin formyltransferase from the extreme thermophile Methanopyrus kandleri."
    Breitung J., Borner G., Scholz S., Linder D., Stetter K.O., Thauer R.K.
    Eur. J. Biochem. 210:971-981(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-48.
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
  3. "Formylmethanofuran: tetrahydromethanopterin formyltransferase and N5,N10-methylenetetrahydromethanopterin dehydrogenase from the sulfate-reducing Archaeoglobus fulgidus: similarities with the enzymes from methanogenic Archaea."
    Schworer B., Breitung J., Klein A.R., Stetter K.O., Thauer R.K.
    Arch. Microbiol. 159:225-232(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-48, FUNCTION.
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
  4. "Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship."
    Mamat B., Roth A., Grimm C., Ermler U., Tziatzios C., Schubert D., Thauer R.K., Shima S.
    Protein Sci. 11:2168-2178(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiFTR_ARCFU
AccessioniPrimary (citable) accession number: O28076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3