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Protein

Formylmethanofuran--tetrahydromethanopterin formyltransferase

Gene

ftr

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H4MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H4MPT).1 Publication

Catalytic activityi

Formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin.

Pathwayi: lactate oxidation

This protein is involved in the pathway lactate oxidation, which is part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the pathway lactate oxidation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processOne-carbon metabolism

Enzyme and pathway databases

BRENDAi2.3.1.101 414
UniPathwayiUPA00701

Names & Taxonomyi

Protein namesi
Recommended name:
Formylmethanofuran--tetrahydromethanopterin formyltransferase (EC:2.3.1.101)
Alternative name(s):
H4MPT formyltransferase
Gene namesi
Name:ftr
Ordered Locus Names:AF_2207
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001381151 – 297Formylmethanofuran--tetrahydromethanopterin formyltransferaseAdd BLAST297

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224325.AF2207

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Beta strandi12 – 26Combined sources15
Helixi30 – 41Combined sources12
Turni47 – 49Combined sources3
Beta strandi53 – 60Combined sources8
Helixi62 – 64Combined sources3
Beta strandi71 – 80Combined sources10
Helixi81 – 95Combined sources15
Turni96 – 98Combined sources3
Beta strandi103 – 107Combined sources5
Beta strandi112 – 115Combined sources4
Helixi117 – 121Combined sources5
Helixi122 – 125Combined sources4
Beta strandi130 – 134Combined sources5
Beta strandi137 – 143Combined sources7
Beta strandi145 – 153Combined sources9
Beta strandi155 – 172Combined sources18
Helixi173 – 188Combined sources16
Helixi198 – 200Combined sources3
Beta strandi202 – 204Combined sources3
Beta strandi207 – 209Combined sources3
Helixi222 – 224Combined sources3
Helixi226 – 228Combined sources3
Helixi229 – 232Combined sources4
Beta strandi243 – 253Combined sources11
Helixi254 – 268Combined sources15
Beta strandi274 – 278Combined sources5
Turni283 – 285Combined sources3
Beta strandi288 – 292Combined sources5
Helixi293 – 295Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M5HX-ray2.00A/B/C/D/E/F/G/H1-297[»]
ProteinModelPortaliO28076
SMRiO28076
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28076

Family & Domainsi

Sequence similaritiesi

Belongs to the FTR family.Curated

Phylogenomic databases

eggNOGiarCOG02695 Archaea
COG2037 LUCA
KOiK00672
OMAiCPAEAGI
OrthoDBiPOG093Z09PX

Family and domain databases

Gene3Di3.30.70.520, 3 hits
HAMAPiMF_00579 FTR, 1 hit
InterProiView protein in InterPro
IPR014053 ForMFR_H4MPT_ForTrfase
IPR002770 ForMFR_H4MPT_ForTrfase_C
IPR023447 ForMFR_H4MPT_ForTrfase_fd-like
IPR022667 ForMFR_H4MPT_ForTrfase_N
PfamiView protein in Pfam
PF01913 FTR, 1 hit
PF02741 FTR_C, 1 hit
PIRSFiPIRSF006414 Ftr_formyl_trnsf, 1 hit
SUPFAMiSSF55112 SSF55112, 2 hits
TIGRFAMsiTIGR03119 one_C_fhcD, 1 hit

Sequencei

Sequence statusi: Complete.

O28076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNGVEVEE TFAEAFDIKI ARVLITGYDY YWAWVAANEA TGFGTSVIMC
60 70 80 90 100
PAEAGIEIKA KPSETPDGRP GYYIQICHMS KKGLEEQLLA RLGQCVLTAP
110 120 130 140 150
TTAVFNGLPD AEEKFDTGFK LKFFADGYEK EVEVGGRKCW AVPMMEGDFI
160 170 180 190 200
IENDIGYTNG IAGGNFFIMA ETQPSALAAA KAAVDAISDV EGVITPFPGG
210 220 230 240 250
IVASGSKVGA NKYKFLKAST NEKFAPSIRD QVEGTQIPEG VKAVYEIVIN
260 270 280 290
GLNADAIKEA TRVGILAATK IPGVVKITAG NYGGKLGKHI INLNELF
Length:297
Mass (Da):31,762
Last modified:January 1, 1998 - v1
Checksum:i1466551AFFE97E4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32Missing AA sequence (PubMed:1483480).Curated1
Sequence conflicti32Missing AA sequence (PubMed:8481089).Curated1
Sequence conflicti34W → I AA sequence (PubMed:1483480).Curated1
Sequence conflicti34W → I AA sequence (PubMed:8481089).Curated1
Sequence conflicti43F → T AA sequence (PubMed:8481089).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89046.1
PIRiG69525
RefSeqiWP_010879696.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89046; AAB89046; AF_2207
GeneIDi24795956
KEGGiafu:AF_2207

Similar proteinsi

Entry informationi

Entry nameiFTR_ARCFU
AccessioniPrimary (citable) accession number: O28076
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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