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Protein

Formylmethanofuran--tetrahydromethanopterin formyltransferase

Gene

ftr

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H4MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H4MPT).1 Publication

Catalytic activityi

Formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin.

Pathwayi: lactate oxidation

This protein is involved in the pathway lactate oxidation, which is part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the pathway lactate oxidation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

One-carbon metabolism

Enzyme and pathway databases

BRENDAi2.3.1.101. 414.
UniPathwayiUPA00701.

Names & Taxonomyi

Protein namesi
Recommended name:
Formylmethanofuran--tetrahydromethanopterin formyltransferase (EC:2.3.1.101)
Alternative name(s):
H4MPT formyltransferase
Gene namesi
Name:ftr
Ordered Locus Names:AF_2207
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001381151 – 297Formylmethanofuran--tetrahydromethanopterin formyltransferaseAdd BLAST297

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224325.AF2207.

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Beta strandi12 – 26Combined sources15
Helixi30 – 41Combined sources12
Turni47 – 49Combined sources3
Beta strandi53 – 60Combined sources8
Helixi62 – 64Combined sources3
Beta strandi71 – 80Combined sources10
Helixi81 – 95Combined sources15
Turni96 – 98Combined sources3
Beta strandi103 – 107Combined sources5
Beta strandi112 – 115Combined sources4
Helixi117 – 121Combined sources5
Helixi122 – 125Combined sources4
Beta strandi130 – 134Combined sources5
Beta strandi137 – 143Combined sources7
Beta strandi145 – 153Combined sources9
Beta strandi155 – 172Combined sources18
Helixi173 – 188Combined sources16
Helixi198 – 200Combined sources3
Beta strandi202 – 204Combined sources3
Beta strandi207 – 209Combined sources3
Helixi222 – 224Combined sources3
Helixi226 – 228Combined sources3
Helixi229 – 232Combined sources4
Beta strandi243 – 253Combined sources11
Helixi254 – 268Combined sources15
Beta strandi274 – 278Combined sources5
Turni283 – 285Combined sources3
Beta strandi288 – 292Combined sources5
Helixi293 – 295Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M5HX-ray2.00A/B/C/D/E/F/G/H1-297[»]
ProteinModelPortaliO28076.
SMRiO28076.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28076.

Family & Domainsi

Sequence similaritiesi

Belongs to the FTR family.Curated

Phylogenomic databases

eggNOGiarCOG02695. Archaea.
COG2037. LUCA.
KOiK00672.
OMAiSVIMCPA.

Family and domain databases

Gene3Di3.30.70.520. 2 hits.
HAMAPiMF_00579. FTR. 1 hit.
InterProiIPR014053. ForMFR_H4MPT_ForTrfase.
IPR002770. ForMFR_H4MPT_ForTrfase_C.
IPR023447. ForMFR_H4MPT_ForTrfase_fd-like.
IPR022667. ForMFR_H4MPT_ForTrfase_N.
[Graphical view]
PfamiPF01913. FTR. 1 hit.
PF02741. FTR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006414. Ftr_formyl_trnsf. 1 hit.
SUPFAMiSSF55112. SSF55112. 2 hits.
TIGRFAMsiTIGR03119. one_C_fhcD. 1 hit.

Sequencei

Sequence statusi: Complete.

O28076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNGVEVEE TFAEAFDIKI ARVLITGYDY YWAWVAANEA TGFGTSVIMC
60 70 80 90 100
PAEAGIEIKA KPSETPDGRP GYYIQICHMS KKGLEEQLLA RLGQCVLTAP
110 120 130 140 150
TTAVFNGLPD AEEKFDTGFK LKFFADGYEK EVEVGGRKCW AVPMMEGDFI
160 170 180 190 200
IENDIGYTNG IAGGNFFIMA ETQPSALAAA KAAVDAISDV EGVITPFPGG
210 220 230 240 250
IVASGSKVGA NKYKFLKAST NEKFAPSIRD QVEGTQIPEG VKAVYEIVIN
260 270 280 290
GLNADAIKEA TRVGILAATK IPGVVKITAG NYGGKLGKHI INLNELF
Length:297
Mass (Da):31,762
Last modified:January 1, 1998 - v1
Checksum:i1466551AFFE97E4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32Missing AA sequence (PubMed:1483480).Curated1
Sequence conflicti32Missing AA sequence (PubMed:8481089).Curated1
Sequence conflicti34W → I AA sequence (PubMed:1483480).Curated1
Sequence conflicti34W → I AA sequence (PubMed:8481089).Curated1
Sequence conflicti43F → T AA sequence (PubMed:8481089).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89046.1.
PIRiG69525.
RefSeqiWP_010879696.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89046; AAB89046; AF_2207.
GeneIDi24795956.
KEGGiafu:AF_2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89046.1.
PIRiG69525.
RefSeqiWP_010879696.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M5HX-ray2.00A/B/C/D/E/F/G/H1-297[»]
ProteinModelPortaliO28076.
SMRiO28076.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89046; AAB89046; AF_2207.
GeneIDi24795956.
KEGGiafu:AF_2207.

Phylogenomic databases

eggNOGiarCOG02695. Archaea.
COG2037. LUCA.
KOiK00672.
OMAiSVIMCPA.

Enzyme and pathway databases

UniPathwayiUPA00701.
BRENDAi2.3.1.101. 414.

Miscellaneous databases

EvolutionaryTraceiO28076.

Family and domain databases

Gene3Di3.30.70.520. 2 hits.
HAMAPiMF_00579. FTR. 1 hit.
InterProiIPR014053. ForMFR_H4MPT_ForTrfase.
IPR002770. ForMFR_H4MPT_ForTrfase_C.
IPR023447. ForMFR_H4MPT_ForTrfase_fd-like.
IPR022667. ForMFR_H4MPT_ForTrfase_N.
[Graphical view]
PfamiPF01913. FTR. 1 hit.
PF02741. FTR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006414. Ftr_formyl_trnsf. 1 hit.
SUPFAMiSSF55112. SSF55112. 2 hits.
TIGRFAMsiTIGR03119. one_C_fhcD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTR_ARCFU
AccessioniPrimary (citable) accession number: O28076
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.