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Protein

Thermosome subunit alpha

Gene

thsA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thermosome subunit alpha
Alternative name(s):
Chaperonin subunit alpha
Thermosome subunit 1
Gene namesi
Name:thsA
Ordered Locus Names:AF_2238
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283811 – 545Thermosome subunit alphaAdd BLAST545

Interactioni

Subunit structurei

Forms a Heterooligomeric complex of two stacked eight-membered rings.By similarity

Protein-protein interaction databases

STRINGi224325.AF2238.

Structurei

3D structure databases

ProteinModelPortaliO28045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
OMAiYDQACEI.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O28045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLQGTPVL ILKEGTQRTV GRDAQRMNIM AARVIAEAVK STLGPKGMDK
60 70 80 90 100
MLVDSLGDVV ITNDGVTILK EMDVEHPAAK MIIEVAKTQD NEVGDGTTTA
110 120 130 140 150
VVLAGELLKK AEELLDQDIH PTVIARGYRM AANKAVEILE SIAMDIDVED
160 170 180 190 200
EETLKKIAAT AITGKHSEYA LDHLSSLVVE AVKRVAEKVD DRYKVDEDNI
210 220 230 240 250
KLEKRQGGSV ADTKLVNGIV IDKEVVHPGM PKRVKNAKIA VLKAALEVKE
260 270 280 290 300
TETDAEIRIT DPDQLMKFIE QEEKMLKEMV DRLAEAGANV VFCQKGIDDL
310 320 330 340 350
AQYYLAKAGI LAVRRVKQSD IEKIAKACGA KIITDLREIT SADLGEAELV
360 370 380 390 400
EERKVGDEKM VFIEGCKNPK AVTILIRGGS EHVVDEVERS LQDAIKVVKT
410 420 430 440 450
ALESGKVVAG GGAPEIEVAL KIRDWAPTLG GREQLAAEAF ASALEVIPRA
460 470 480 490 500
LAENSGLDPI DILVELRKAH EEGKTTYGVD VFSGEVACMK ERGVLEPLKV
510 520 530 540
KTQAITSATE VAIMILRIDD VIAAKGLEKE KGPEGESGGE EDSEE
Length:545
Mass (Da):58,978
Last modified:January 1, 1998 - v1
Checksum:iC774722EE6AA4EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89014.1.
AF035826 Genomic DNA. Translation: AAB88860.1.
PIRiF69529.
RefSeqiWP_010879727.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89014; AAB89014; AF_2238.
GeneIDi24796000.
KEGGiafu:AF_2238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89014.1.
AF035826 Genomic DNA. Translation: AAB88860.1.
PIRiF69529.
RefSeqiWP_010879727.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO28045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89014; AAB89014; AF_2238.
GeneIDi24796000.
KEGGiafu:AF_2238.

Phylogenomic databases

eggNOGiarCOG01257. Archaea.
COG0459. LUCA.
OMAiYDQACEI.

Family and domain databases

CDDicd03343. cpn60. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
IPR012714. Thermosome_arc.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHSA_ARCFU
AccessioniPrimary (citable) accession number: O28045
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.