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O28032

- ASSY_ARCFU

UniProt

O28032 - ASSY_ARCFU

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Protein

Argininosuccinate synthase

Gene
argG, AF_2252
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Citrulline By similarity
Binding sitei113 – 1131ATP; via amide nitrogen By similarity
Binding sitei115 – 1151Aspartate By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei119 – 1191Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei169 – 1691Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei254 – 2541Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 149ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-2300-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:AF_2252
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Argininosuccinate synthaseUniRule annotationPRO_0000148671Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF2252.

Structurei

3D structure databases

ProteinModelPortaliO28032.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiPECEYIR.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O28032-1 [UniParc]FASTAAdd to Basket

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MKVVLSYSGG LDTTVCIPLL KEKYGFDEVI TVTVDIGQPE ADIKQAEERG    50
KKYADKHYTI DAKKEFVDSL FMLIKANGNY EGYVLGTALA RPLIAEKVVE 100
VAKKEGAEAV AHGCTGKGND QLRFENIFRQ HGFKVIAPVR ELNLTREWEI 150
EYARQHGIEV PATKEKPYSI DENLWSRSVE GGKLEDPSFE PPEDIYEWTA 200
SPEKAPDKPE IVKIDFEKGV PVALNDERMG GFELIKALNE IGGKHGVGRT 250
DMIEDRVLGL KARENYEHPA ATILITAHRD LENLVLSRRE LKFKKFVEEE 300
WAELVYYGLV NDPLFDALNA FIDKTQERVT GWVKVKLYKG SAVVVARNSP 350
YALYSEELVS FDTESIDQRL AEGFAAFHGL QGRLFRRLFQ 390
Length:390
Mass (Da):44,104
Last modified:January 1, 1998 - v1
Checksum:i31334D84F696EE8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89005.1.
PIRiD69531.
RefSeqiNP_071077.1. NC_000917.1.
WP_010879741.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89005; AAB89005; AF_2252.
GeneIDi1485483.
KEGGiafu:AF2252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB89005.1 .
PIRi D69531.
RefSeqi NP_071077.1. NC_000917.1.
WP_010879741.1. NC_000917.1.

3D structure databases

ProteinModelPortali O28032.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF2252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB89005 ; AAB89005 ; AF_2252 .
GeneIDi 1485483.
KEGGi afu:AF2252.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi PECEYIR.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci AFUL224325:GJBC-2300-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiASSY_ARCFU
AccessioniPrimary (citable) accession number: O28032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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