O27983 (PDAD1_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase 1
Short name=PvlArgDC 1
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase 1 subunit beta
2. Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha

Gene names

Name:	pdaD1
Ordered Locus Names:	AF_2301

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.
Sequence caution	The sequence AAB88952.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 40	40	Pyruvoyl-dependent arginine decarboxylase 1 subunit beta By similarity		PRO_0000023304
	Chain	41 – 157	117	Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha By similarity		PRO_0000023305
Sites
	Site	40 – 41	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	41	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O27983 [UniParc]. Last modified July 11, 2002. Version 2. Checksum: 2A77CE5332244078	FASTA	157	17,205
	10 20 30 40 50 60 MLPRKVFFTK GVGRHTDPLV SFELALRDAG IEKFNLVTVS SIYPPYCEIV EAEKGLSELF 70 80 90 100 110 120 PGQIVFCVMS RMTSNEQGKR IFASVGAAIP PDPSLNGYLT EYHGYCNGED AGRHAEESAA 130 140 150 YMLKTAFEIE PARTFNITVE ADVEDCTTVV AAAVFVI

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB88952.1. Different initiation.
PIR	E69537.
RefSeq	NP_071126.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O27983.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1485533.
GenomeReviews	Gene locus AF_2301 in contig AE000782_GR.
KEGG	afu:AF2301.
NMPDR	fig|224325.1.peg.2287.
TIGR	AF_2301.
Phylogenomic databases
HOGENOM	HBG539680.
OMA	HCKRISV.
ProtClustDB	PRK12398.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_2301-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
TIGRFAMs	TIGR00286. TIGR00286. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD1_ARCFU

Accession

Primary (citable) accession number: O27983

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	November 16, 2011
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program