O27958 (IF2B_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit beta

Alternative name(s):
aIF2-beta
eIF-2-beta

Gene names

Name:	eif2b
Ordered Locus Names:	AF_2326

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00232
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the eIF-2-beta/eIF-5 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Translation initiation factor 2 subunit beta HAMAP-Rule MF_00232		PRO_0000137417

Sequences

	Sequence		Length	Mass (Da)
	O27958 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 11B962290D144E83	FASTA	137	16,088
	10 20 30 40 50 60 MMRSYEELLE RAFEKLADKD VVRRERFEIP RVSIQREGAR TILKNFSQIA KTLNRSEDHL 70 80 90 100 110 120 YKYIVKSLGT AGFIDNGRLV LQGKFTESEL QKEVDDYVRL YVLCRECNSP DTEFIKEERV 130 LMLRCLACGA KHPVRNI

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB88931.1.
PIR	F69540.
RefSeq	NP_071151.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O27958.
SMR	O27958. Positions 102-137.
ModBase	Search...
Protein-protein interaction databases
STRING	224325.AF2326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB88931; AAB88931; AF_2326.
GeneID	1485558.
KEGG	afu:AF2326.
Phylogenomic databases
eggNOG	COG1601.
KO	K03238.
OMA	EYVICRE.
ProtClustDB	PRK03988.
Enzyme and pathway databases
BioCyc	AFUL224325:GJBC-2375-MONOMER.
Family and domain databases
Gene3D	3.30.30.50. 1 hit.
HAMAP	MF_00232. eIF-2-beta.
InterPro	IPR004458. TIF2_bsu_arc. IPR002735. Transl_init_fac_IF2/IF5. IPR016189. Transl_init_fac_IF2/IF5_N. IPR016190. Transl_init_fac_IF2/IF5_Zn-bd. [Graphical view]
Pfam	PF01873. eIF-5_eIF-2B. 1 hit. [Graphical view]
SMART	SM00653. eIF2B_5. 1 hit. [Graphical view]
SUPFAM	SSF100966. Transl_init_fac_IF2/IF5_N. 1 hit. SSF75689. Transl_init_fac_IF2/IF5_Zn-bd. 1 hit.
TIGRFAMs	TIGR00311. aIF-2beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF2B_ARCFU

Accession

Primary (citable) accession number: O27958

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program