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Protein

Translation initiation factor 2 subunit beta

Gene

eif2b

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

GO - Molecular functioni

  1. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-2375-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit beta
Alternative name(s):
aIF2-beta
eIF-2-beta
Gene namesi
Name:eif2b
Ordered Locus Names:AF_2326
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Translation initiation factor 2 subunit betaPRO_0000137417Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi224325.AF2326.

Structurei

3D structure databases

ProteinModelPortaliO27958.
SMRiO27958. Positions 102-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2-beta/eIF-5 family.Curated

Phylogenomic databases

eggNOGiCOG1601.
KOiK03238.
OMAiKDGAFTR.

Family and domain databases

Gene3Di3.30.30.50. 1 hit.
HAMAPiMF_00232. eIF_2_beta.
InterProiIPR004458. TIF2_bsu_arc.
IPR002735. Transl_init_fac_IF2/IF5.
IPR016189. Transl_init_fac_IF2/IF5_N.
IPR016190. Transl_init_fac_IF2/IF5_Zn-bd.
[Graphical view]
PfamiPF01873. eIF-5_eIF-2B. 1 hit.
[Graphical view]
SMARTiSM00653. eIF2B_5. 1 hit.
[Graphical view]
SUPFAMiSSF100966. SSF100966. 1 hit.
SSF75689. SSF75689. 1 hit.
TIGRFAMsiTIGR00311. aIF-2beta. 1 hit.

Sequencei

Sequence statusi: Complete.

O27958-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRSYEELLE RAFEKLADKD VVRRERFEIP RVSIQREGAR TILKNFSQIA
60 70 80 90 100
KTLNRSEDHL YKYIVKSLGT AGFIDNGRLV LQGKFTESEL QKEVDDYVRL
110 120 130
YVLCRECNSP DTEFIKEERV LMLRCLACGA KHPVRNI
Length:137
Mass (Da):16,088
Last modified:January 1, 1998 - v1
Checksum:i11B962290D144E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB88931.1.
PIRiF69540.
RefSeqiNP_071151.1. NC_000917.1.
WP_010879815.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB88931; AAB88931; AF_2326.
GeneIDi1485558.
KEGGiafu:AF2326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB88931.1.
PIRiF69540.
RefSeqiNP_071151.1. NC_000917.1.
WP_010879815.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO27958.
SMRiO27958. Positions 102-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF2326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB88931; AAB88931; AF_2326.
GeneIDi1485558.
KEGGiafu:AF2326.

Phylogenomic databases

eggNOGiCOG1601.
KOiK03238.
OMAiKDGAFTR.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-2375-MONOMER.

Family and domain databases

Gene3Di3.30.30.50. 1 hit.
HAMAPiMF_00232. eIF_2_beta.
InterProiIPR004458. TIF2_bsu_arc.
IPR002735. Transl_init_fac_IF2/IF5.
IPR016189. Transl_init_fac_IF2/IF5_N.
IPR016190. Transl_init_fac_IF2/IF5_Zn-bd.
[Graphical view]
PfamiPF01873. eIF-5_eIF-2B. 1 hit.
[Graphical view]
SMARTiSM00653. eIF2B_5. 1 hit.
[Graphical view]
SUPFAMiSSF100966. SSF100966. 1 hit.
SSF75689. SSF75689. 1 hit.
TIGRFAMsiTIGR00311. aIF-2beta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiIF2B_ARCFU
AccessioniPrimary (citable) accession number: O27958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.