ID   AROE_ARCFU              Reviewed;         269 AA.
AC   O27957;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 65.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=AF_2327;
OS   Archaeoglobus fulgidus.
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales;
OC   Archaeoglobaceae; Archaeoglobus.
OX   NCBI_TaxID=2234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
RX   MEDLINE=98049343; PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA   Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA   Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA   Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA   Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA   Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA   Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA   Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA   Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA   Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA   Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-
RT   reducing archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AE000782; AAB88930.1; -; Genomic_DNA.
DR   PIR; G69540; G69540.
DR   RefSeq; NP_071152.1; -.
DR   HSSP; Q58484; 1NVT.
DR   GeneID; 1485559; -.
DR   GenomeReviews; AE000782_GR; AF_2327.
DR   KEGG; afu:AF2327; -.
DR   NMPDR; fig|224325.1.peg.2313; -.
DR   TIGR; AF_2327; -.
DR   HOGENOM; O27957; -.
DR   OMA; O27957; VFDIVYN.
DR   BioCyc; AFUL224325:AF_2327-MON; -.
DR   BRENDA; 1.1.1.25; 7576.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    269       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000136057.
FT   NP_BIND     120    124       NADP (By similarity).
FT   ACT_SITE     65     65       Proton acceptor (Potential).
SQ   SEQUENCE   269 AA;  29137 MW;  86C67419C539877D CRC64;
     MLYLGVIGYP IKHSVSPAMH NAALQHEGIE GIYLAFEVKP DRLRDAVFGA KALGFRGLNV
     TIPFKESVVE FVELEGEAAK IKTVNTIDLV EMVGYNTDVY GVKAALSGTE LGGKTALVVG
     AGGAGKAAAL ALLDMGSTVI VANRTEEKGR EAVEMLRRYG ECIFWPLSRV EELKGKVDVV
     VNATPLGMRG FKAEIPVPPS MLDGVELVFD TVYNPMETPL IREAKKRGCK VVYGIEMLVH
     QGAKAFEIWT GIEPDVGVMR EAALRALRF
//