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Reviewed, UniProtKB/Swiss-Prot O27881 (IORB_METTH)

Last modified July 13, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information
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Names and originHide

Protein namesRecommended name:
Indolepyruvate oxidoreductase subunit iorB

Short name=IOR
EC=1.2.7.8
Alternative name(s):
Indolepyruvate ferredoxin oxidoreductase subunit beta
Gene names
Name:iorB
Ordered Locus Names:MTH_1853
OrganismMethanobacterium thermoautotrophicum [Complete proteome] [HAMAP]
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
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Protein attributesHide

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates By similarity.

Catalytic activity

(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.

Subunit structure

Heterodimer of the iorA and iorB subunits.

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OntologiesHide

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionindolepyruvate ferredoxin oxidoreductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...
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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Indolepyruvate oxidoreductase subunit iorB
PRO_0000099932
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SequencesHide

Sequence LengthMass (Da)Tools
O27881-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CF1A16D8535BD034

FASTA19620,948
        10         20         30         40         50         60 
MNYNIYVCGV GGQGIIKTSV IIGEAAMKKD INVVMSEIHG MAQRGGSVST EIRIGEVHGS 

        70         80         90        100        110        120 
IIPDGEADLV LAFEPLEAIR ALPKMSEESE VILNTSVIPP FNLMRSPHPY PPLDEIMSTL 

       130        140        150        160        170        180 
EERAGSVRGF NAEEIALKAG HILSLNMVML GAAAATPGFP LESESLISSM RDNLPSRLID 

       190 
VNLRAFRDGF GAAAES 

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ReferencesHide

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
AE000666 Genomic DNA. Translation: AAB86319.1.
PIRH69114.
RefSeqNP_276959.1.

3D structure databases

SMRO27881. Positions 2-195.
ModBaseSearch...

Protein-protein interaction databases

STRINGO27881.

Genome annotation databases

GeneID1470938.
GenomeReviewsGene locus MTH_1853 in contig AE000666_GR.
KEGGmth:MTH1853.
NMPDRfig|187420.1.peg.1814.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG09698.
HOGENOMHBG553299.
OMAVILSFEP.
ProtClustDBPRK06853.

Enzyme and pathway databases

BioCycMTHE187420:MTH1853-MONOMER.
BRENDA1.2.7.8. 270.

Family and domain databases

InterProIPR017719. Indolepyruvate_Fd_OxRdtase_bsu.
IPR019752. Pyrv/ketoisovalerate_OxRed_cat.
IPR002869. Pyrv_flavodox_OxRed_cen.
[Graphical view]
Gene3DG3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
PfamPF01558. POR. 1 hit.
[Graphical view]
SUPFAMSSF53323. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
TIGRFAMsTIGR03334. IOR_beta. 1 hit.
ProtoNetSearch...
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Entry informationHide

Entry nameIORB_METTH
AccessionPrimary (citable) accession number: O27881
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 13, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information