ID   IORA_METTH              Reviewed;         618 AA.
AC   O27880;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 66.
DE   RecName: Full=Indolepyruvate oxidoreductase subunit iorA;
DE            Short=IOR;
DE            EC=1.2.7.8;
DE   AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha;
GN   Name=iorA; OrderedLocusNames=MTH_1852;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative
CC       decarboxylation of arylpyruvates (By similarity).
CC   -!- CATALYTIC ACTIVITY: (Indol-3-yl)pyruvate + CoA + 2 oxidized
CC       ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster.
CC   -!- SUBUNIT: Heterodimer of the iorA and iorB subunits.
CC   -!- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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DR   EMBL; AE000666; AAB86318.1; -; Genomic_DNA.
DR   PIR; G69114; G69114.
DR   RefSeq; NP_276958.1; -.
DR   HSSP; Q45560; 1BWE.
DR   GeneID; 1470937; -.
DR   GenomeReviews; AE000666_GR; MTH_1852.
DR   KEGG; mth:MTH1852; -.
DR   NMPDR; fig|187420.1.peg.1813; -.
DR   HOGENOM; O27880; -.
DR   OMA; O27880; VADDPSM.
DR   BioCyc; MTHE187420:MTH1852-MON; -.
DR   BRENDA; 1.2.7.8; 270.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase ac...; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamin pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd_subgr.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR011766; TPP_enzyme_bd_C.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   TIGRFAMs; TIGR03336; IOR_alpha; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    618       Indolepyruvate oxidoreductase subunit
FT                                iorA.
FT                                /FTId=PRO_0000099926.
FT   DOMAIN      558    587       4Fe-4S ferredoxin-type 1.
FT   DOMAIN      588    617       4Fe-4S ferredoxin-type 2.
FT   METAL       597    597       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       600    600       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       603    603       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       607    607       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   618 AA;  66871 MW;  B2D222FF7983F203 CRC64;
     MELEDILNAR EGDKLFLLGN EATVRAAIES GVGVASTYPG TPSSEIGNVL SGIAKRAGMY
     FEFSVNEKVA LEVAAAAAAS GVRSFTFMKH VGLNVASDSF MSTAYTGVRA GMVVLTADDP
     SMFSSQNEQD NRHYARLACL PLLEPSDPQE VLEFMNHAFE LSEDYGLPVL LRTTTRVSHM
     RGVVEVGSRM REPSEGFFRK DPERFVPVPA TARVMHRKLV DKMKELRIRA DESELNRVFN
     GGSDSELGVV ASGGAFNYVY DALESLGLEL PVLKLGFTYP FPAGLVEEFL SGLKRVLVVE
     EVDPIMEREV LAVAGSARLD LDVHGKLDGT LPEIYEYNED ILRKAISGLT GAPSVERECD
     VPDIPERPPS LCPGCPHRAV YYAVRRAADE LELSGDEIIF PTDIGCYTLG IEPPYSAADY
     LLSMGSSIGT SCGFSAATTQ RIVSFIGDST FFHAGIPPLI NAVHNKQRFV LVVLDNRTTA
     MTGGQPHPGL PVDGMGDEAP EISIEEIVRA SGVEFVETVN PMNIKRTSET VKRALEHESV
     AVVISKYPCM LSSGAVRGRP MAVDGEKCDL CLECIRDLAC PAMVTREGEV FIDPLKCRGC
     SVCLQICPAG AIKPEGKG
//