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Protein

dTDP-4-dehydrorhamnose 3,5-epimerase

Gene

rmlC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.1 Publication

Catalytic activityi

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose.1 Publication

Pathwayi: dTDP-L-rhamnose biosynthesis

This protein is involved in the pathway dTDP-L-rhamnose biosynthesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway dTDP-L-rhamnose biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26SubstrateBy similarity1
Binding sitei31SubstrateBy similarity1
Binding sitei61Substrate1 Publication1
Binding sitei64SubstrateBy similarity1
Binding sitei73SubstrateBy similarity1
Binding sitei84SubstrateBy similarity1
Binding sitei120SubstrateBy similarity1
Binding sitei172SubstrateBy similarity1

GO - Molecular functioni

  • dTDP-4-dehydrorhamnose 3,5-epimerase activity Source: UniProtKB

GO - Biological processi

  • dTDP-rhamnose biosynthetic process Source: UniProtKB-UniPathway
  • extracellular polysaccharide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00124.

Names & Taxonomyi

Protein namesi
Recommended name:
dTDP-4-dehydrorhamnose 3,5-epimerase (EC:5.1.3.13)
Alternative name(s):
Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
dTDP-4-keto-6-deoxyglucose 3,5-epimerase
dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
dTDP-L-rhamnose synthase
Gene namesi
Name:rmlC
Ordered Locus Names:MTH_1790
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953511 – 185dTDP-4-dehydrorhamnose 3,5-epimeraseAdd BLAST185

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi187420.MTH1790.

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Beta strandi15 – 19Combined sources5
Beta strandi21 – 24Combined sources4
Beta strandi27 – 30Combined sources4
Helixi35 – 40Combined sources6
Beta strandi49 – 56Combined sources8
Beta strandi59 – 69Combined sources11
Beta strandi73 – 88Combined sources16
Turni94 – 97Combined sources4
Beta strandi99 – 105Combined sources7
Turni106 – 108Combined sources3
Beta strandi111 – 114Combined sources4
Beta strandi118 – 124Combined sources7
Beta strandi126 – 137Combined sources12
Helixi141 – 143Combined sources3
Beta strandi144 – 146Combined sources3
Turni152 – 154Combined sources3
Helixi160 – 162Combined sources3
Helixi170 – 173Combined sources4
Turni178 – 180Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EP0X-ray1.50A1-185[»]
1EPZX-ray1.75A1-185[»]
ProteinModelPortaliO27818.
SMRiO27818.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27818.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Substrate binding3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04188. Archaea.
COG1898. LUCA.
KOiK01790.
OMAiNPFVYGE.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR21047. PTHR21047. 1 hit.
PfamiPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomiPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01221. rmlC. 1 hit.

Sequencei

Sequence statusi: Complete.

O27818-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFRFIKTS LDGAIIIEPE VYTDERGYFM ETFNEAIFQE NGLEVRFVQD
60 70 80 90 100
NESMSVRGVL RGLHFQREKP QGKLVRVIRG EIFDVAVDLR KNSDTYGEWT
110 120 130 140 150
GVRLSDENRR EFFIPEGFAH GFLALSDECI VNYKCTELYH PEYDSGIPWD
160 170 180
DPDIGIDWPL EMVDDLIISE KDRNWKPLRE NPVYL
Length:185
Mass (Da):21,678
Last modified:January 1, 1998 - v1
Checksum:iE321B0D881834139
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86256.1.
PIRiB69106.
RefSeqiWP_010877392.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86256; AAB86256; MTH_1790.
GeneIDi1470875.
KEGGimth:MTH_1790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86256.1.
PIRiB69106.
RefSeqiWP_010877392.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EP0X-ray1.50A1-185[»]
1EPZX-ray1.75A1-185[»]
ProteinModelPortaliO27818.
SMRiO27818.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86256; AAB86256; MTH_1790.
GeneIDi1470875.
KEGGimth:MTH_1790.

Phylogenomic databases

eggNOGiarCOG04188. Archaea.
COG1898. LUCA.
KOiK01790.
OMAiNPFVYGE.

Enzyme and pathway databases

UniPathwayiUPA00124.

Miscellaneous databases

EvolutionaryTraceiO27818.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR000888. dTDP_sugar_isom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR21047. PTHR21047. 1 hit.
PfamiPF00908. dTDP_sugar_isom. 1 hit.
[Graphical view]
ProDomiPD001462. dTDP_sugar_isom. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01221. rmlC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRMLC_METTH
AccessioniPrimary (citable) accession number: O27818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.