Reviewed, UniProtKB/Swiss-Prot O27772 (PORC_METTH)

Names and origin

Protein names

Recommended name:
    Pyruvate synthase subunit porC
    EC=1.2.7.1
Alternative name(s):
    Pyruvate oxidoreductase gamma chain
      Short name=POR
    Pyruvic-ferredoxin oxidoreductase subunit gamma

Gene names

Name:	porC
Ordered Locus Names:	MTH_1740

Organism

Methanobacterium thermoautotrophicum [Complete proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.
Subunit structure	Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Caution	There seems to be a sequencing error that fuses together porC and porD. We have cut the ORF into its two constituents.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyruvate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Pyruvate synthase subunit porC		PRO_0000099911

Sequences

	Sequence		Length	Mass (Da)
	O27772-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: F209CCFF749B2032	FASTA	180	19,524
	10 20 30 40 50 60 MIEIRFHGRG GQGAVTAAEI LAKAAFEDGK YSQAFPFFGV ERRGAPVMAF TRIDDSPVRR 70 80 90 100 110 120 RYQVYNPDYV VVLDEGLVDV VDVFSGLKDD GVVVLNKSGD FQGGDVKVHT IDATGIALET 130 140 150 160 170 180 LGRPIVNTVM LGAFAGVTGL VSIDSLIKII KETFPGKIGE KNAEAARMAY EEIEKLRVNM

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB86210.1. Different termination.
3D structure databases
SMR	O27772. Positions 1-175.
ModBase	Search...
Protein-protein interaction databases
STRING	O27772.
Genome annotation databases
GenomeReviews	Gene locus MTH_1740 in contig AE000666_GR.
KEGG	mth:MTH1740.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG07814.
HOGENOM	HBG553299.
OMA	KEIRIHG.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14531.
BRENDA	1.2.7.1. 270.
Family and domain databases
InterPro	IPR011894. PorC_KorC. IPR019752. Pyrv/ketoisovalerate_OxRed_cat. IPR002869. Pyrv_flavodox_OxRed_cen. [Graphical view]
Gene3D	G3DSA:3.40.920.10. Pyrv_Fd/Flavodoxin_OxRdtase. 1 hit.
Pfam	PF01558. POR. 1 hit. [Graphical view]
TIGRFAMs	TIGR02175. PorC_KorC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PORC_METTH

Accession

Primary (citable) accession number: O27772

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 30, 2000
Last modified:	February 9, 2010
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)