ID   ACDB_METTH              Reviewed;         460 AA.
AC   O27745;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-MAY-2012, entry version 70.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit beta;
DE            Short=ACDS complex subunit beta;
DE            EC=2.3.1.-;
DE   AltName: Full=ACDS complex acyltransferase;
GN   Name=cdhC; OrderedLocusNames=MTH_1710;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 /
OS   JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage
CC       of acetyl-CoA, allowing autotrophic growth from CO(2) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + [acetyl-CoA
CC       decarbonylase/synthase complex beta subunit] = CoA + acetyl-
CC       [acetyl-CoA decarbonylase/synthase complex beta subunit].
CC   -!- COFACTOR: Binds 1 nickel-iron-sulfur cluster (By similarity).
CC   -!- SUBUNIT: Monomer. The ACDS complex is made up of alpha, epsilon,
CC       beta, gamma and delta chains with a probable stoichiometry of
CC       (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (Potential).
CC   -!- SIMILARITY: Belongs to the CdhC family.
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DR   EMBL; AE000666; AAB86182.1; -; Genomic_DNA.
DR   PIR; H69095; H69095.
DR   RefSeq; NP_276822.1; NC_000916.1.
DR   ProteinModelPortal; O27745; -.
DR   IntAct; O27745; 1.
DR   STRING; O27745; -.
DR   GeneID; 1470795; -.
DR   GenomeReviews; AE000666_GR; MTH_1710.
DR   KEGG; mth:MTH1710; -.
DR   eggNOG; COG1614; -.
DR   KO; K00193; -.
DR   OMA; KFLQADG; -.
DR   ProtClustDB; PRK04456; -.
DR   BioCyc; MTHE187420:MTH1710-MONOMER; -.
DR   GO; GO:0018492; F:carbon-monoxide dehydrogenase (acceptor) activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   HAMAP; MF_01138; CdhC; 1; -.
DR   InterPro; IPR004461; CO_DH/Ac-CoA_synth_bsu.
DR   InterPro; IPR023432; CO_DH/Ac-CoA_synth_bsu_arc.
DR   InterPro; IPR011254; Prismane-like.
DR   Pfam; PF03598; CdhC; 1.
DR   SUPFAM; SSF56821; Prismane_like; 1.
DR   TIGRFAMs; TIGR00316; CdhC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Nickel; Reference proteome; Transferase.
FT   CHAIN         1    460       Acetyl-CoA decarbonylase/synthase complex
FT                                subunit beta.
FT                                /FTId=PRO_0000155108.
FT   COMPBIAS    402    413       Glu-rich.
FT   METAL       188    188       Nickel-iron-sulfur (Potential).
FT   METAL       191    191       Nickel-iron-sulfur (Potential).
FT   METAL       277    277       Nickel-iron-sulfur (Potential).
FT   METAL       279    279       Nickel-iron-sulfur (Potential).
SQ   SEQUENCE   460 AA;  51737 MW;  DB4D50693D154BDA CRC64;
     MFEDIPVDVS PMHEGERIRS ANMFVELAGP KSIGAELVQV KDEVEDGKVE VKGPEIDEME
     QGQVYPFAIN VEVAGSELEE ELESVIERRL HELCNYVKGF MHLNQRDQIW CRVSTEAKDA
     GFRLEHLGKA LSVLFREEFP IIESIAVTLM TDEAAVQEFL ETAREKYETR DSRARELSDE
     DVDVFYGCLM CQSFAPTHVC IVTPDRTALC GAINWFDCRA AYKMDPDGPI FEIEKGEVLD
     PERGEYANVN AAVEENSQGT TDRVYLHSVF GYPHTSCGCF EAVAFYIPEL DGIGIVNRDF
     RGETPLGIPF SAMAGQCSGG KQVEGFSGLS LEYMRSPKFL QADGGYHRVI WMPRELKESV
     LEFIPEDVRD KIATEEDATS IKDLRRFLRD NEHPVLERAA VEETEPEEEE VEEAYPEETP
     IPEGVPVMAA PEMTLPAAGG FRIVLKNAKI YAEKVIIKRK
//