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Protein

Acetyl-CoA decarbonylase/synthase complex subunit beta

Gene

cdhC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO2. The alpha-epsilon complex generates CO from CO2, while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).UniRule annotation

Catalytic activityi

Acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein].UniRule annotation

Cofactori

[Ni-Fe-S] clusterUniRule annotationNote: Binds 1 [Ni-Fe-S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi188Nickel-iron-sulfurUniRule annotation1
Metal bindingi191Nickel-iron-sulfurUniRule annotation1
Metal bindingi277Nickel-iron-sulfurUniRule annotation1
Metal bindingi279Nickel-iron-sulfurUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandIron, Iron-sulfur, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1662-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit betaUniRule annotation (EC:2.3.1.169UniRule annotation)
Short name:
ACDS complex subunit betaUniRule annotation
Alternative name(s):
ACDS complex acyltransferaseUniRule annotation
Gene namesi
Name:cdhCUniRule annotation
Ordered Locus Names:MTH_1710
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001551081 – 460Acetyl-CoA decarbonylase/synthase complex subunit betaAdd BLAST460

Interactioni

Subunit structurei

Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha2epsilon2)4-beta8-(gamma1delta1)8.UniRule annotation

Protein-protein interaction databases

IntActiO27745, 1 interactor
STRINGi187420.MTH1710

Structurei

3D structure databases

ProteinModelPortaliO27745
SMRiO27745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 413Glu-richAdd BLAST12

Sequence similaritiesi

Belongs to the CdhC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04360 Archaea
COG1614 LUCA
KOiK00193
OMAiFMHLNQR
OrthoDBiPOG093Z045T

Family and domain databases

Gene3Di3.30.1650.10, 1 hit
HAMAPiMF_01138 CdhC, 1 hit
InterProiView protein in InterPro
IPR004461 CO_DH/Ac-CoA_synth_bsu
IPR038571 CO_DH/Ac-CoA_synth_bsu_3_sf
IPR023432 CO_DH/Ac-CoA_synth_bsu_arc
IPR011254 Prismane-like_sf
PANTHERiPTHR42281 PTHR42281, 1 hit
PfamiView protein in Pfam
PF03598 CdhC, 1 hit
SUPFAMiSSF56821 SSF56821, 1 hit
TIGRFAMsiTIGR00316 cdhC, 1 hit

Sequencei

Sequence statusi: Complete.

O27745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEDIPVDVS PMHEGERIRS ANMFVELAGP KSIGAELVQV KDEVEDGKVE
60 70 80 90 100
VKGPEIDEME QGQVYPFAIN VEVAGSELEE ELESVIERRL HELCNYVKGF
110 120 130 140 150
MHLNQRDQIW CRVSTEAKDA GFRLEHLGKA LSVLFREEFP IIESIAVTLM
160 170 180 190 200
TDEAAVQEFL ETAREKYETR DSRARELSDE DVDVFYGCLM CQSFAPTHVC
210 220 230 240 250
IVTPDRTALC GAINWFDCRA AYKMDPDGPI FEIEKGEVLD PERGEYANVN
260 270 280 290 300
AAVEENSQGT TDRVYLHSVF GYPHTSCGCF EAVAFYIPEL DGIGIVNRDF
310 320 330 340 350
RGETPLGIPF SAMAGQCSGG KQVEGFSGLS LEYMRSPKFL QADGGYHRVI
360 370 380 390 400
WMPRELKESV LEFIPEDVRD KIATEEDATS IKDLRRFLRD NEHPVLERAA
410 420 430 440 450
VEETEPEEEE VEEAYPEETP IPEGVPVMAA PEMTLPAAGG FRIVLKNAKI
460
YAEKVIIKRK
Length:460
Mass (Da):51,737
Last modified:January 1, 1998 - v1
Checksum:iDB4D50693D154BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB86182.1
PIRiH69095
RefSeqiWP_010877318.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB86182; AAB86182; MTH_1710
GeneIDi1470795
KEGGimth:MTH_1710
PATRICifig|187420.15.peg.1671

Similar proteinsi

Entry informationi

Entry nameiACDB_METTH
AccessioniPrimary (citable) accession number: O27745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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