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O27745

- ACDB_METTH

UniProt

O27745 - ACDB_METTH

Protein

Acetyl-CoA decarbonylase/synthase complex subunit beta

Gene

cdhC

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + [acetyl-CoA decarbonylase/synthase complex beta subunit] = CoA + acetyl-[acetyl-CoA decarbonylase/synthase complex beta subunit].UniRule annotation

    Cofactori

    Binds 1 nickel-iron-sulfur cluster.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi188 – 1881Nickel-iron-sulfurUniRule annotation
    Metal bindingi191 – 1911Nickel-iron-sulfurUniRule annotation
    Metal bindingi277 – 2771Nickel-iron-sulfurUniRule annotation
    Metal bindingi279 – 2791Nickel-iron-sulfurUniRule annotation

    GO - Molecular functioni

    1. acetyltransferase activity Source: UniProtKB-HAMAP
    2. carbon-monoxide dehydrogenase (acceptor) activity Source: InterPro
    3. iron ion binding Source: UniProtKB-HAMAP
    4. iron-sulfur cluster binding Source: UniProtKB-KW
    5. nickel cation binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA metabolic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, Nickel

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-1713-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA decarbonylase/synthase complex subunit betaUniRule annotation (EC:2.3.1.-UniRule annotation)
    Short name:
    ACDS complex subunit betaUniRule annotation
    Alternative name(s):
    ACDS complex acyltransferaseUniRule annotation
    Gene namesi
    Name:cdhCUniRule annotation
    Ordered Locus Names:MTH_1710
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Acetyl-CoA decarbonylase/synthase complex subunit betaPRO_0000155108Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha2epsilon2)(4)-beta(8)-(gamma1delta1)8.UniRule annotation

    Protein-protein interaction databases

    IntActiO27745. 1 interaction.
    STRINGi187420.MTH1710.

    Structurei

    3D structure databases

    ProteinModelPortaliO27745.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi402 – 41312Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CdhC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1614.
    KOiK00193.
    OMAiIWCRVSK.

    Family and domain databases

    HAMAPiMF_01138. CdhC.
    InterProiIPR004461. CO_DH/Ac-CoA_synth_bsu.
    IPR023432. CO_DH/Ac-CoA_synth_bsu_arc.
    IPR011254. Prismane-like.
    [Graphical view]
    PfamiPF03598. CdhC. 1 hit.
    [Graphical view]
    SUPFAMiSSF56821. SSF56821. 1 hit.
    TIGRFAMsiTIGR00316. cdhC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O27745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEDIPVDVS PMHEGERIRS ANMFVELAGP KSIGAELVQV KDEVEDGKVE    50
    VKGPEIDEME QGQVYPFAIN VEVAGSELEE ELESVIERRL HELCNYVKGF 100
    MHLNQRDQIW CRVSTEAKDA GFRLEHLGKA LSVLFREEFP IIESIAVTLM 150
    TDEAAVQEFL ETAREKYETR DSRARELSDE DVDVFYGCLM CQSFAPTHVC 200
    IVTPDRTALC GAINWFDCRA AYKMDPDGPI FEIEKGEVLD PERGEYANVN 250
    AAVEENSQGT TDRVYLHSVF GYPHTSCGCF EAVAFYIPEL DGIGIVNRDF 300
    RGETPLGIPF SAMAGQCSGG KQVEGFSGLS LEYMRSPKFL QADGGYHRVI 350
    WMPRELKESV LEFIPEDVRD KIATEEDATS IKDLRRFLRD NEHPVLERAA 400
    VEETEPEEEE VEEAYPEETP IPEGVPVMAA PEMTLPAAGG FRIVLKNAKI 450
    YAEKVIIKRK 460
    Length:460
    Mass (Da):51,737
    Last modified:January 1, 1998 - v1
    Checksum:iDB4D50693D154BDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB86182.1.
    PIRiH69095.
    RefSeqiNP_276822.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB86182; AAB86182; MTH_1710.
    GeneIDi1470795.
    KEGGimth:MTH1710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB86182.1 .
    PIRi H69095.
    RefSeqi NP_276822.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O27745.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O27745. 1 interaction.
    STRINGi 187420.MTH1710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB86182 ; AAB86182 ; MTH_1710 .
    GeneIDi 1470795.
    KEGGi mth:MTH1710.

    Phylogenomic databases

    eggNOGi COG1614.
    KOi K00193.
    OMAi IWCRVSK.

    Enzyme and pathway databases

    BioCyci MTHE187420:GJNM-1713-MONOMER.

    Family and domain databases

    HAMAPi MF_01138. CdhC.
    InterProi IPR004461. CO_DH/Ac-CoA_synth_bsu.
    IPR023432. CO_DH/Ac-CoA_synth_bsu_arc.
    IPR011254. Prismane-like.
    [Graphical view ]
    Pfami PF03598. CdhC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56821. SSF56821. 1 hit.
    TIGRFAMsi TIGR00316. cdhC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiACDB_METTH
    AccessioniPrimary (citable) accession number: O27745
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3