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O27695

- TRPF_METTH

UniProt

O27695 - TRPF_METTH

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase
Gene
trpF, MTH_1658
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1660-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:MTH_1658
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
PRO_0000154407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1658.

Structurei

3D structure databases

ProteinModelPortaliO27695.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
OMAiCLDFNSG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

O27695-1 [UniParc]FASTAAdd to Basket

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MNSSHESLAD VLVKICGIKR PEDAILADKL GADLLGLIHV ERSPRHLTGR    50
ELEDILSLIP PEKAVIVLEP SDPVEVAEVI ERTGVERVQL HSISCEDARG 100
IKRVLTENGF NPGITVAVPP EPGSLDVLDH IPCSCVMLDS SSGGRTGGTG 150
RMIPPELALG MLRLIRSHES APEVALAGGL GPSTVRLNPE YLLEFDCLDF 200
NSGIEAAPGI KDHAMMFELM EYMGRTGGLQ KPSRLQRGEL S 241
Length:241
Mass (Da):25,926
Last modified:January 1, 1998 - v1
Checksum:i3CB027196E8729DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86130.1.
PIRiF69088.
RefSeqiNP_276770.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86130; AAB86130; MTH_1658.
GeneIDi1470743.
KEGGimth:MTH1658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86130.1 .
PIRi F69088.
RefSeqi NP_276770.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86130 ; AAB86130 ; MTH_1658 .
GeneIDi 1470743.
KEGGi mth:MTH1658.

Phylogenomic databases

eggNOGi COG0135.
OMAi CLDFNSG.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci MTHE187420:GJNM-1660-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiTRPF_METTH
AccessioniPrimary (citable) accession number: O27695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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