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O27695

- TRPF_METTH

UniProt

O27695 - TRPF_METTH

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciMTHE187420:GJNM-1660-MONOMER.
    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpF
    Ordered Locus Names:MTH_1658
    OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri187420 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000005223: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154407Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187420.MTH1658.

    Structurei

    3D structure databases

    ProteinModelPortaliO27695.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0135.
    OMAiCLDFNSG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O27695-1 [UniParc]FASTAAdd to Basket

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    MNSSHESLAD VLVKICGIKR PEDAILADKL GADLLGLIHV ERSPRHLTGR    50
    ELEDILSLIP PEKAVIVLEP SDPVEVAEVI ERTGVERVQL HSISCEDARG 100
    IKRVLTENGF NPGITVAVPP EPGSLDVLDH IPCSCVMLDS SSGGRTGGTG 150
    RMIPPELALG MLRLIRSHES APEVALAGGL GPSTVRLNPE YLLEFDCLDF 200
    NSGIEAAPGI KDHAMMFELM EYMGRTGGLQ KPSRLQRGEL S 241
    Length:241
    Mass (Da):25,926
    Last modified:January 1, 1998 - v1
    Checksum:i3CB027196E8729DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB86130.1.
    PIRiF69088.
    RefSeqiNP_276770.1. NC_000916.1.

    Genome annotation databases

    EnsemblBacteriaiAAB86130; AAB86130; MTH_1658.
    GeneIDi1470743.
    KEGGimth:MTH1658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000666 Genomic DNA. Translation: AAB86130.1 .
    PIRi F69088.
    RefSeqi NP_276770.1. NC_000916.1.

    3D structure databases

    ProteinModelPortali O27695.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187420.MTH1658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB86130 ; AAB86130 ; MTH_1658 .
    GeneIDi 1470743.
    KEGGi mth:MTH1658.

    Phylogenomic databases

    eggNOGi COG0135.
    OMAi CLDFNSG.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    BioCyci MTHE187420:GJNM-1660-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

    Entry informationi

    Entry nameiTRPF_METTH
    AccessioniPrimary (citable) accession number: O27695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3