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O27695

- TRPF_METTH

UniProt

O27695 - TRPF_METTH

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1660-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpF
Ordered Locus Names:MTH_1658
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1658.

Structurei

3D structure databases

ProteinModelPortaliO27695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
OMAiCLDFNSG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

O27695 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSSHESLAD VLVKICGIKR PEDAILADKL GADLLGLIHV ERSPRHLTGR
60 70 80 90 100
ELEDILSLIP PEKAVIVLEP SDPVEVAEVI ERTGVERVQL HSISCEDARG
110 120 130 140 150
IKRVLTENGF NPGITVAVPP EPGSLDVLDH IPCSCVMLDS SSGGRTGGTG
160 170 180 190 200
RMIPPELALG MLRLIRSHES APEVALAGGL GPSTVRLNPE YLLEFDCLDF
210 220 230 240
NSGIEAAPGI KDHAMMFELM EYMGRTGGLQ KPSRLQRGEL S
Length:241
Mass (Da):25,926
Last modified:January 1, 1998 - v1
Checksum:i3CB027196E8729DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86130.1.
PIRiF69088.
RefSeqiNP_276770.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86130; AAB86130; MTH_1658.
GeneIDi1470743.
KEGGimth:MTH1658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86130.1 .
PIRi F69088.
RefSeqi NP_276770.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27695.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86130 ; AAB86130 ; MTH_1658 .
GeneIDi 1470743.
KEGGi mth:MTH1658.

Phylogenomic databases

eggNOGi COG0135.
OMAi CLDFNSG.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci MTHE187420:GJNM-1660-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiTRPF_METTH
AccessioniPrimary (citable) accession number: O27695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3