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O27694 (TRPC_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:MTH_1657
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A

Sequence similarities

Belongs to the TrpC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Indole-3-glycerol phosphate synthase HAMAP MF_00134_A
PRO_0000154294

Sequences

Sequence LengthMass (Da)Tools
O27694 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9655070B7228F9BE

FASTA27230,042
        10         20         30         40         50         60 
MLRDIIRSKK LEVKELMKKT PLSILRDDIT VMDEPVSFPA AVGGGKVSLI CEYKRASPSM 

        70         80         90        100        110        120 
GRISERGLEE MMEVYQDLAD AVSIVTDGKY FKGSLDLLSG ATDYGKPLLM KDFLVDEYKI 

       130        140        150        160        170        180 
YQARASGASS VLLITGVFPD LEAGIQKCRE LSMEPLVECH TSLDIFRALE AGAEIIGVNN 

       190        200        210        220        230        240 
RDLETFEVDL ERTHALAPLV PDELILVSES GVRGPEDAEI LAGYGADALL IGTAPMSAQN 

       250        260        270 
PRELLEEIVD AVSQCRDRRR RYTGDEFFEQ FA

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB86129.1.
PIRE69088.
RefSeqNP_276769.1. NC_000916.1.

3D structure databases

ProteinModelPortalO27694.
ModBaseSearch...

Protein-protein interaction databases

STRINGO27694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1470742.
GenomeReviewsGene locus MTH_1657 in contig AE000666_GR.
KEGGmth:MTH1657.
NMPDRfig|187420.1.peg.1624.

Phylogenomic databases

eggNOGarNOG04622.
HOGENOMHBG540956.
OMAVESLGMT.
PhylomeDBO27694.
ProtClustDBCLSK2750637.

Enzyme and pathway databases

BioCycMTHE187420:MTH1657-MONOMER.

Family and domain databases

HAMAPMF_00134_A. IGPS_A.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_METTH
AccessionPrimary (citable) accession number: O27694
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 19, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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