O27692 (TRPE_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	MTH_1655

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Anthranilate synthase component 1		PRO_0000154129

Sequences

	Sequence		Length	Mass (Da)
	O27692 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 1ED3E402D6E3FA2E	FASTA	464	52,321
	10 20 30 40 50 60 MNVFGITELK NPVKEKIEFK EPFELFKSIY SEYDSSFLLE SMESDTGLAR YSFMGFEPQM 70 80 90 100 110 120 IIRARSGFIE VEYEGSREEF DTENPFEFLR QFTRPAGKSR GFCGGLVGYI SYQAARFFDS 130 140 150 160 170 180 INLSPGNFPD FEFGLFLDGI MFNHLTGECS YISLKENRLP EISELLREET PTGHLKYRSM 190 200 210 220 230 240 GTLFSRRRYL GMVEEARERI AEGEIFQAVL SNATDYRLRG DRLALYEALR RVNPSPYMYH 250 260 270 280 290 300 LKLGSREITG SSPEMLVRVE DKQIETFPIA GTRPRGKTPH EDERIAAELL SDEKELAEHL 310 320 330 340 350 360 MLVDLARNDL GRISEFGTVQ VPEYMTIRRF SHVQHILSHV TGRLRKGMDA LDALGAVFPA 370 380 390 400 410 420 GTVSGAPKIR AMEIIESLEG VPRNAYAGAL GYLSLNGNAD FAITIRSMVA EGAYGRIQAG 430 440 450 460 AGIVHDSVPE REYVECQNKA MAVLKSMELA GDGFDSDEPF IARR

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB86127.1.
PIR	C69088.
RefSeq	NP_276767.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O27692.
ModBase	Search...
Protein-protein interaction databases
STRING	O27692.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1470740.
GenomeReviews	Gene locus MTH_1655 in contig AE000666_GR.
KEGG	mth:MTH1655.
NMPDR	fig|187420.1.peg.1622.
Phylogenomic databases
eggNOG	arNOG04620.
HOGENOM	HBG507440.
OMA	ICCNPIA.
PhylomeDB	O27692.
ProtClustDB	CLSK878523.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1655-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR010116. Anthranilate_synth_I_arc. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR01820. TrpE-arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_METTH

Accession

Primary (citable) accession number: O27692

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program