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Protein

Putative ribose 1,5-bisphosphate isomerase

Gene

MTH_1620

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of ribose 1,5-bisphosphate to ribulose 1,5-bisphosphate (RuBP), the CO2 acceptor and substrate for RubisCO.UniRule annotation

Catalytic activityi

Alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate.UniRule annotation

Cofactori

NAD+UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 5529NADUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1622-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ribose 1,5-bisphosphate isomeraseUniRule annotation (EC:5.3.1.29UniRule annotation)
Alternative name(s):
Ribulose 1,5-bisphosphate synthaseUniRule annotation
Short name:
RuBP synthaseUniRule annotation
Gene namesi
Ordered Locus Names:MTH_1620
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Putative ribose 1,5-bisphosphate isomerasePRO_0000153950Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi187420.MTH1620.

Structurei

3D structure databases

ProteinModelPortaliO27657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574. Archaea.
COG1635. LUCA.
KOiK03146.
OMAiRMGPVFG.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00304. Thi4. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002922. Thi4_fam.
IPR022828. Thi4_putative.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00292. TIGR00292. 1 hit.

Sequencei

Sequence statusi: Complete.

O27657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDDIKISR AIVEGYMEDL LDYMEMDVAI GGGGPSGLTA GYYLARAGLK
60 70 80 90 100
VALFERKLSI GGGMWGGGMM FNKIVVQDEG REILDEFGIR SEPYDEGYHV
110 120 130 140 150
ADSVEATSTL CSRACQAGLK IFNLMSIEDV MIRDEGITGL VLNWSSVEMA
160 170 180 190 200
GLHVDPLTVR ARAVIDATGH DCEIVKVVER KIGPELNTPD GRIQGERSMW
210 220 230 240 250
ADVGEAALIE NTREVYPNLY VAGMASNAVY GAPRMGPIFG GMLVSGRRVA

EMIIEKLK
Length:258
Mass (Da):28,043
Last modified:October 31, 2006 - v2
Checksum:iFA11B3320F2DCFCA
GO

Sequence cautioni

The sequence AAB86093 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86093.1. Different initiation.
PIRiE69083.
RefSeqiWP_048061316.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86093; AAB86093; MTH_1620.
GeneIDi24854722.
KEGGimth:MTH_1620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86093.1. Different initiation.
PIRiE69083.
RefSeqiWP_048061316.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO27657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1620.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86093; AAB86093; MTH_1620.
GeneIDi24854722.
KEGGimth:MTH_1620.

Phylogenomic databases

eggNOGiarCOG00574. Archaea.
COG1635. LUCA.
KOiK03146.
OMAiRMGPVFG.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1622-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00304. Thi4. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002922. Thi4_fam.
IPR022828. Thi4_putative.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00292. TIGR00292. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRUBPS_METTH
AccessioniPrimary (citable) accession number: O27657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 31, 2006
Last modified: July 6, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.