Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O27655

- RNP4_METTH

UniProt

O27655 - RNP4_METTH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonuclease P protein component 4

Gene

rnp4

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 PublicationUniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631ZincUniRule annotation
Metal bindingi66 – 661ZincUniRule annotation
Metal bindingi89 – 891ZincUniRule annotation
Metal bindingi92 – 921ZincUniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 4UniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P component 4UniRule annotation
Alternative name(s):
Rpp21UniRule annotation
Gene namesi
Name:rnp4UniRule annotation
Ordered Locus Names:MTH_1618
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. ribonuclease P complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonuclease P protein component 4PRO_0000153856Add
BLAST

Expressioni

Inductioni

Constitutively expressed (at protein level).1 Publication

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.1 PublicationUniRule annotation

Protein-protein interaction databases

IntActiO27655. 1 interaction.
STRINGi187420.MTH1618.

Structurei

3D structure databases

ProteinModelPortaliO27655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2023.
KOiK03540.
OMAiPRKWKRR.

Family and domain databases

HAMAPiMF_00757. RNase_P_4.
InterProiIPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]
PIRSFiPIRSF004878. RNase_P_4. 1 hit.

Sequencei

Sequence statusi: Complete.

O27655-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRGKRPRWM LKIAEERIDI LFRMADREFS ANPHRSHRYT ELARNIAMKY
60 70 80 90 100
RVRIPREWRR RFCRKCYSFL KPGANCTVRI ADGKVNFRCH ECGHIMRFPY
110 120 130 140
IREKKDRRRN KIESHTTKEG TDEQITVGAH NKCGESQSDR
Length:140
Mass (Da):16,954
Last modified:January 1, 1998 - v1
Checksum:i78F37D4EEFA74FE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86091.1.
PIRiB69083.
RefSeqiNP_276730.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86091; AAB86091; MTH_1618.
GeneIDi1470703.
KEGGimth:MTH1618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86091.1 .
PIRi B69083.
RefSeqi NP_276730.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O27655. 1 interaction.
STRINGi 187420.MTH1618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86091 ; AAB86091 ; MTH_1618 .
GeneIDi 1470703.
KEGGi mth:MTH1618.

Phylogenomic databases

eggNOGi COG2023.
KOi K03540.
OMAi PRKWKRR.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-1620-MONOMER.

Family and domain databases

HAMAPi MF_00757. RNase_P_4.
InterProi IPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
PIRSFi PIRSF004878. RNase_P_4. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. "Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins."
    Hall T.A., Brown J.W.
    RNA 8:296-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION.
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiRNP4_METTH
AccessioniPrimary (citable) accession number: O27655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3