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O27655

- RNP4_METTH

UniProt

O27655 - RNP4_METTH

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Protein
Ribonuclease P protein component 4
Gene
rnp4, MTH_1618
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.1 Publication

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Zinc By similarity
Metal bindingi66 – 661Zinc By similarity
Metal bindingi89 – 891Zinc By similarity
Metal bindingi92 – 921Zinc By similarity

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 4 (EC:3.1.26.5)
Short name:
RNase P component 4
Alternative name(s):
Rpp21
Gene namesi
Name:rnp4
Ordered Locus Names:MTH_1618
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. ribonuclease P complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonuclease P protein component 4UniRule annotation
PRO_0000153856Add
BLAST

Expressioni

Inductioni

Constitutively expressed (at protein level).1 Publication

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.1 Publication

Protein-protein interaction databases

IntActiO27655. 1 interaction.
STRINGi187420.MTH1618.

Structurei

3D structure databases

ProteinModelPortaliO27655.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2023.
KOiK03540.
OMAiPRKWKRR.

Family and domain databases

HAMAPiMF_00757. RNase_P_4.
InterProiIPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view]
PANTHERiPTHR14742. PTHR14742. 1 hit.
PfamiPF04032. Rpr2. 1 hit.
[Graphical view]
PIRSFiPIRSF004878. RNase_P_4. 1 hit.

Sequencei

Sequence statusi: Complete.

O27655-1 [UniParc]FASTAAdd to Basket

« Hide

MRRGKRPRWM LKIAEERIDI LFRMADREFS ANPHRSHRYT ELARNIAMKY    50
RVRIPREWRR RFCRKCYSFL KPGANCTVRI ADGKVNFRCH ECGHIMRFPY 100
IREKKDRRRN KIESHTTKEG TDEQITVGAH NKCGESQSDR 140
Length:140
Mass (Da):16,954
Last modified:January 1, 1998 - v1
Checksum:i78F37D4EEFA74FE8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86091.1.
PIRiB69083.
RefSeqiNP_276730.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86091; AAB86091; MTH_1618.
GeneIDi1470703.
KEGGimth:MTH1618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000666 Genomic DNA. Translation: AAB86091.1 .
PIRi B69083.
RefSeqi NP_276730.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O27655. 1 interaction.
STRINGi 187420.MTH1618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86091 ; AAB86091 ; MTH_1618 .
GeneIDi 1470703.
KEGGi mth:MTH1618.

Phylogenomic databases

eggNOGi COG2023.
KOi K03540.
OMAi PRKWKRR.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-1620-MONOMER.

Family and domain databases

HAMAPi MF_00757. RNase_P_4.
InterProi IPR016432. RNase_P_comp-4.
IPR007175. Rpr2.
[Graphical view ]
PANTHERi PTHR14742. PTHR14742. 1 hit.
Pfami PF04032. Rpr2. 1 hit.
[Graphical view ]
PIRSFi PIRSF004878. RNase_P_4. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. "Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins."
    Hall T.A., Brown J.W.
    RNA 8:296-306(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION.
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiRNP4_METTH
AccessioniPrimary (citable) accession number: O27655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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