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Protein

Translation initiation factor 6

Gene

eif6

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 6UniRule annotation
Short name:
aIF-6UniRule annotation
Gene namesi
Name:eif6UniRule annotation
Ordered Locus Names:MTH_1611
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Translation initiation factor 6PRO_0000153750Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1611.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ADXelectron microscopy6.60I1-222[»]
ProteinModelPortaliO27648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
KOiK03264.
OMAiNDWCAFT.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

O27648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRRINLSGN PNLGVYISVT DSVALIPQNT PEKFEGVLRE ALEVEVLKVS
60 70 80 90 100
ISGSSLNGAL AVGNSNGFVV SNQAMDREID ALAAAGVEAV RIPERFTAVG
110 120 130 140 150
NLVLANDNGA VASPLLSDDA LQVIGDVLEV DVKVSTLAGL NIVGSMGAAT
160 170 180 190 200
NRGALLNPQA SSEEIGIIED TLGVEADVGT VNHGVTLIGA CSVANSNGVL
210 220
VGEETTGPEL ARIEEALGFL EG
Length:222
Mass (Da):22,658
Last modified:January 1, 1998 - v1
Checksum:iB86780BEC5C82533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86084.1.
PIRiC69082.
RefSeqiWP_010877219.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86084; AAB86084; MTH_1611.
GeneIDi24854713.
KEGGimth:MTH_1611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86084.1.
PIRiC69082.
RefSeqiWP_010877219.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ADXelectron microscopy6.60I1-222[»]
ProteinModelPortaliO27648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86084; AAB86084; MTH_1611.
GeneIDi24854713.
KEGGimth:MTH_1611.

Phylogenomic databases

eggNOGiarCOG04176. Archaea.
COG1976. LUCA.
KOiK03264.
OMAiNDWCAFT.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1613-MONOMER.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiIF6_METTH
AccessioniPrimary (citable) accession number: O27648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.