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O27642

- DUT_METTH

UniProt

O27642 - DUT_METTH

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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1607-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:MTH_1605
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000153641Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1605.

Structurei

3D structure databases

ProteinModelPortaliO27642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
KOiK01520.
OMAiGEYNGSY.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00635. dUTPase_arch.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

O27642-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMIGEQLLKK LFPDFEELVQ PAGIDLRVDK VYRQMGPGSL IDDEKNLPPL
60 70 80 90 100
EMLEPPIYRL EPGKAYLASV DRMIEIPEGY AMLYLPRSTL LRSFVSVQTA
110 120 130 140 150
VGDPGFRGTL QFLLHNHGEY EYTLKRGERI VQAVVFPVEG SGKYSGSYQE
Length:150
Mass (Da):16,997
Last modified:January 1, 1998 - v1
Checksum:iAFA09D55FB371648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86078.1.
PIRiD69081.
RefSeqiNP_276717.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86078; AAB86078; MTH_1605.
GeneIDi1471874.
KEGGimth:MTH1605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86078.1 .
PIRi D69081.
RefSeqi NP_276717.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27642.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86078 ; AAB86078 ; MTH_1605 .
GeneIDi 1471874.
KEGGi mth:MTH1605.

Phylogenomic databases

eggNOGi COG0717.
KOi K01520.
OMAi GEYNGSY.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci MTHE187420:GJNM-1607-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00635. dUTPase_arch.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR023537. dUTPase_archaeal.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiDUT_METTH
AccessioniPrimary (citable) accession number: O27642
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3