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O27635

- ARCH_METTH

UniProt

O27635 - ARCH_METTH

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Protein

Protein archease

Gene

MTH_1598

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121CalciumBy similarity
Metal bindingi139 – 1391CalciumBy similarity
Metal bindingi140 – 1401Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein archeaseUniRule annotation
Gene namesi
Ordered Locus Names:MTH_1598
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Protein archeasePRO_0000068846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1598.

Structurei

Secondary structure

1
140
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Beta strandi10 – 189Combined sources
Beta strandi20 – 223Combined sources
Helixi23 – 3715Combined sources
Beta strandi48 – 5811Combined sources
Helixi59 – 7517Combined sources
Beta strandi84 – 896Combined sources
Beta strandi91 – 10111Combined sources
Beta strandi124 – 1285Combined sources
Beta strandi131 – 1399Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JW3NMR-A1-140[»]
ProteinModelPortaliO27635.
SMRiO27635. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27635.

Family & Domainsi

Sequence similaritiesi

Belongs to the archease family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1371.
OMAiPINKKYE.

Family and domain databases

Gene3Di3.55.10.10. 1 hit.
HAMAPiMF_01222. Archease_arch.
InterProiIPR002804. Archease.
IPR022952. Archease_arc.
IPR023572. Archease_dom.
[Graphical view]
PANTHERiPTHR12682. PTHR12682. 1 hit.
PfamiPF01951. Archease. 1 hit.
[Graphical view]
ProDomiPD012969. PD012969. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF69819. SSF69819. 1 hit.

Sequencei

Sequence statusi: Complete.

O27635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGFEFFDVT ADAGFWAYGH DLEEVFENAA LAMFEVMTDT SLVEAAEERR
60 70 80 90 100
VEITSEDRVS LLYDWLDELL FIHDTEFILF SKFKVKIDEK DDGLHLTGTA
110 120 130 140
MGEEIKEGHE RRDEVKAVTF HMMEILDEDG LIKARVILDL
Length:140
Mass (Da):16,183
Last modified:January 1, 1998 - v1
Checksum:i1F82F57056E55AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86071.1.
PIRiC69080.
RefSeqiNP_276710.1. NC_000916.1.
WP_010877206.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86071; AAB86071; MTH_1598.
GeneIDi1471867.
KEGGimth:MTH1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86071.1 .
PIRi C69080.
RefSeqi NP_276710.1. NC_000916.1.
WP_010877206.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JW3 NMR - A 1-140 [» ]
ProteinModelPortali O27635.
SMRi O27635. Positions 1-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB86071 ; AAB86071 ; MTH_1598 .
GeneIDi 1471867.
KEGGi mth:MTH1598.

Phylogenomic databases

eggNOGi COG1371.
OMAi PINKKYE.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-1600-MONOMER.

Miscellaneous databases

EvolutionaryTracei O27635.

Family and domain databases

Gene3Di 3.55.10.10. 1 hit.
HAMAPi MF_01222. Archease_arch.
InterProi IPR002804. Archease.
IPR022952. Archease_arc.
IPR023572. Archease_dom.
[Graphical view ]
PANTHERi PTHR12682. PTHR12682. 1 hit.
Pfami PF01951. Archease. 1 hit.
[Graphical view ]
ProDomi PD012969. PD012969. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF69819. SSF69819. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. "Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts."
    Canaves J.M.
    Proteins 56:19-27(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY FUNCTION.
  3. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiARCH_METTH
AccessioniPrimary (citable) accession number: O27635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3