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Protein

Protein archease

Gene

MTH_1598

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CalciumBy similarity1
Metal bindingi139CalciumBy similarity1
Metal bindingi140Calcium; via carboxylateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:G1G16-1551-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein archeaseUniRule annotation
Gene namesi
Ordered Locus Names:MTH_1598
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688461 – 140Protein archeaseAdd BLAST140

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1598

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 6Combined sources3
Beta strandi10 – 18Combined sources9
Beta strandi20 – 22Combined sources3
Helixi23 – 37Combined sources15
Beta strandi48 – 58Combined sources11
Helixi59 – 75Combined sources17
Beta strandi84 – 89Combined sources6
Beta strandi91 – 101Combined sources11
Beta strandi124 – 128Combined sources5
Beta strandi131 – 139Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JW3NMR-A1-140[»]
ProteinModelPortaliO27635
SMRiO27635
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27635

Family & Domainsi

Sequence similaritiesi

Belongs to the archease family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04055 Archaea
COG1371 LUCA
OMAiYSAMQIH
OrthoDBiPOG093Z0EL6

Family and domain databases

Gene3Di3.55.10.10, 1 hit
HAMAPiMF_01222 Archease_arch, 1 hit
InterProiView protein in InterPro
IPR002804 Archease
IPR022952 Archease_arc
IPR023572 Archease_dom
IPR036820 Archease_dom_sf
PANTHERiPTHR12682 PTHR12682, 1 hit
PfamiView protein in Pfam
PF01951 Archease, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012969 PD012969, 1 hit
SUPFAMiSSF69819 SSF69819, 1 hit

Sequencei

Sequence statusi: Complete.

O27635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFEFFDVT ADAGFWAYGH DLEEVFENAA LAMFEVMTDT SLVEAAEERR
60 70 80 90 100
VEITSEDRVS LLYDWLDELL FIHDTEFILF SKFKVKIDEK DDGLHLTGTA
110 120 130 140
MGEEIKEGHE RRDEVKAVTF HMMEILDEDG LIKARVILDL
Length:140
Mass (Da):16,183
Last modified:January 1, 1998 - v1
Checksum:i1F82F57056E55AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB86071.1
PIRiC69080
RefSeqiWP_010877206.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB86071; AAB86071; MTH_1598
GeneIDi1471867
KEGGimth:MTH_1598
PATRICifig|187420.15.peg.1561

Similar proteinsi

Entry informationi

Entry nameiARCH_METTH
AccessioniPrimary (citable) accession number: O27635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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