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Protein

Protein archease

Gene

MTH_1598

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). May also act as a chaperone or modulator of proteins involved in DNA or RNA processing.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121CalciumBy similarity
Metal bindingi139 – 1391CalciumBy similarity
Metal bindingi140 – 1401Calcium; via carboxylateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1600-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein archeaseUniRule annotation
Gene namesi
Ordered Locus Names:MTH_1598
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Protein archeasePRO_0000068846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1598.

Structurei

Secondary structure

1
140
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Beta strandi10 – 189Combined sources
Beta strandi20 – 223Combined sources
Helixi23 – 3715Combined sources
Beta strandi48 – 5811Combined sources
Helixi59 – 7517Combined sources
Beta strandi84 – 896Combined sources
Beta strandi91 – 10111Combined sources
Beta strandi124 – 1285Combined sources
Beta strandi131 – 1399Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JW3NMR-A1-140[»]
ProteinModelPortaliO27635.
SMRiO27635. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO27635.

Family & Domainsi

Sequence similaritiesi

Belongs to the archease family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04055. Archaea.
COG1371. LUCA.
OMAiDVQIHSW.

Family and domain databases

Gene3Di3.55.10.10. 1 hit.
HAMAPiMF_01222. Archease_arch. 1 hit.
InterProiIPR002804. Archease.
IPR022952. Archease_arc.
IPR023572. Archease_dom.
[Graphical view]
PANTHERiPTHR12682. PTHR12682. 1 hit.
PfamiPF01951. Archease. 1 hit.
[Graphical view]
ProDomiPD012969. PD012969. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF69819. SSF69819. 1 hit.

Sequencei

Sequence statusi: Complete.

O27635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFEFFDVT ADAGFWAYGH DLEEVFENAA LAMFEVMTDT SLVEAAEERR
60 70 80 90 100
VEITSEDRVS LLYDWLDELL FIHDTEFILF SKFKVKIDEK DDGLHLTGTA
110 120 130 140
MGEEIKEGHE RRDEVKAVTF HMMEILDEDG LIKARVILDL
Length:140
Mass (Da):16,183
Last modified:January 1, 1998 - v1
Checksum:i1F82F57056E55AFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86071.1.
PIRiC69080.
RefSeqiWP_010877206.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86071; AAB86071; MTH_1598.
GeneIDi1471867.
KEGGimth:MTH_1598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86071.1.
PIRiC69080.
RefSeqiWP_010877206.1. NC_000916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JW3NMR-A1-140[»]
ProteinModelPortaliO27635.
SMRiO27635. Positions 1-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86071; AAB86071; MTH_1598.
GeneIDi1471867.
KEGGimth:MTH_1598.

Phylogenomic databases

eggNOGiarCOG04055. Archaea.
COG1371. LUCA.
OMAiDVQIHSW.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1600-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO27635.

Family and domain databases

Gene3Di3.55.10.10. 1 hit.
HAMAPiMF_01222. Archease_arch. 1 hit.
InterProiIPR002804. Archease.
IPR022952. Archease_arc.
IPR023572. Archease_dom.
[Graphical view]
PANTHERiPTHR12682. PTHR12682. 1 hit.
PfamiPF01951. Archease. 1 hit.
[Graphical view]
ProDomiPD012969. PD012969. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF69819. SSF69819. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCH_METTH
AccessioniPrimary (citable) accession number: O27635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.