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Protein

Probable phosphoglucosamine mutase

Gene

glmM

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.UniRule annotation

Catalytic activityi

Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101Phosphoserine intermediateUniRule annotation1
Metal bindingi101Magnesium; via phosphate groupUniRule annotation1
Metal bindingi239MagnesiumUniRule annotation1
Metal bindingi241MagnesiumUniRule annotation1
Metal bindingi243MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglucosamine mutaseUniRule annotation (EC:5.4.2.10UniRule annotation)
Gene namesi
Name:glmMUniRule annotation
Ordered Locus Names:MTH_1590
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003378091 – 449Probable phosphoglucosamine mutaseAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineUniRule annotation1

Post-translational modificationi

Activated by phosphorylation.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1590.

Structurei

3D structure databases

ProteinModelPortaliO27627.
SMRiO27627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00767. Archaea.
COG1109. LUCA.
KOiK03431.
OMAiFVLKLGQ.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
HAMAPiMF_01554_A. GlmM_A. 1 hit.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
IPR023666. GlmM_arc.
IPR024086. GlmM_arc-type.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
TIGRFAMsiTIGR03990. Arch_GlmM. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKKPRLFG TSGIRGRFGE KVTLELTAEH RKALATHLGG DGEVVVGYDT
60 70 80 90 100
RTSSQLLENA LIAGIVECGC DVTRLGMVPT PLVGYAASRL GAAAGVMITA
110 120 130 140 150
SHNPAPYNGI KLWNPDGMAY RPSQERVIES IIHSRDFKRK AWDELGSITT
160 170 180 190 200
VDMRDDYVRA VLETVEIKKP LKVVIDSGCG AASHLSPLIF RKAGCRVITL
210 220 230 240 250
NSQPDGFFPG RDPEPVPENL SELMETVRST GADLGIAHDG DADRMVAIDD
260 270 280 290 300
QGRFASFDKL LALMAREIGG KIITTVDASL CVDECLGDRG EVIRTRVGDV
310 320 330 340 350
HVANTIAEEG ARFGGEPSGT WLHPDFCMCP DGILSALRVA ELVSARGPLS
360 370 380 390 400
ELLEEVPSYP NIRDKVPCPD EKKDIIMERV AAELSDQFSE TSDINTIDGV
410 420 430 440
RISLDDGSWV LVRPSGTEPY IRITLEGKTE EKARYIHERT RGYLENVIG
Length:449
Mass (Da):48,915
Last modified:January 1, 1998 - v1
Checksum:i3F1762C7B89DCE7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86063.1.
PIRiC69079.
RefSeqiWP_010877198.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86063; AAB86063; MTH_1590.
GeneIDi1471859.
KEGGimth:MTH_1590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86063.1.
PIRiC69079.
RefSeqiWP_010877198.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO27627.
SMRiO27627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86063; AAB86063; MTH_1590.
GeneIDi1471859.
KEGGimth:MTH_1590.

Phylogenomic databases

eggNOGiarCOG00767. Archaea.
COG1109. LUCA.
KOiK03431.
OMAiFVLKLGQ.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
HAMAPiMF_01554_A. GlmM_A. 1 hit.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR005841. Alpha-D-phosphohexomutase_SF.
IPR023666. GlmM_arc.
IPR024086. GlmM_arc-type.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PRINTSiPR00509. PGMPMM.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
TIGRFAMsiTIGR03990. Arch_GlmM. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLMM_METTH
AccessioniPrimary (citable) accession number: O27627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.