ID   FWDC_METTH              Reviewed;         270 AA.
AC   O27600;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.99.5;
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC; OrderedLocusNames=MTH_1558;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and
CC       methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only
CC       oxidize formylmethanofuran. This enzyme is oxygen-labile.
CC   -!- CATALYTIC ACTIVITY: Formylmethanofuran + H(2)O + acceptor = CO(2)
CC       + methanofuran + reduced acceptor.
CC   -!- COFACTOR: Tungsten.
CC   -!- ENZYME REGULATION: Not inactivated by cyanide.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of seven subunits fwdA (65 kDa),
CC       fwdB (53 kDa), fwdC (31 kDa), fwdD (15 kDa), fwdE, fwdF and fwdG
CC       (By similarity).
CC   -!- INDUCTION: By growth on tungsten or molybdenum under anaerobic
CC       conditions.
CC   -!- SIMILARITY: Belongs to the fwdC/fmdC family.
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DR   EMBL; AE000666; AAB86032.1; -; Genomic_DNA.
DR   PIR; H69074; H69074.
DR   RefSeq; NP_276671.1; -.
DR   TCDB; 3.D.8.1.1; Na+- or H+-pumping formyl methanofuran dehydrogenase (FMF-DH) family.
DR   GeneID; 1471827; -.
DR   GenomeReviews; AE000666_GR; MTH_1558.
DR   KEGG; mth:MTH1558; -.
DR   NMPDR; fig|187420.1.peg.1526; -.
DR   HOGENOM; O27600; -.
DR   OMA; O27600; YVGSAYR.
DR   BioCyc; MTHE187420:MTH1558-MON; -.
DR   BRENDA; 1.2.99.5; 270.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synthase_C.
DR   Gene3D; G3DSA:2.160.20.60; Glu_synthase_C; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Methanogenesis; Oxidoreductase; Repeat; Tungsten.
FT   CHAIN         1    270       Tungsten-containing formylmethanofuran
FT                                dehydrogenase 2 subunit C.
FT                                /FTId=PRO_0000144196.
FT   REPEAT       80     92       1.
FT   REPEAT       99    111       2.
FT   REPEAT      118    130       3.
FT   REPEAT      144    156       4.
FT   REPEAT      163    175       5.
FT   REPEAT      182    194       6.
FT   REPEAT      201    213       7.
FT   REGION       80    213       7 X 13 AA repeats of [GW]-X-X-M-X-X-G-X-
FT                                [IL]-X-[IV]-X-G.
SQ   SEQUENCE   270 AA;  28641 MW;  043A9FFBBA554D36 CRC64;
     MSEIILTPKE QPEVPLEAPN IKPDVFAGKS IDEIRNIQIM HGNEVVKLGD FFEVSGEPAD
     SAADIKIIID GDVYNTKRIG QDMTAGEILV KGNVNMYVGA GMKGGKITVE GNAKSWAGQD
     MRGGELEIFG DAGDYVGSSY RGDWRGMSGG VITVHGNAGN EIGEYMNGGK IIIKGDVNIM
     PGIHMNNGLI IIEGNAVARV GGEMAGGTIV VKGMIEEFLP GFKYLGVEKD IEVNGETFPG
     AYYKFEGDHA IKGAKGMVYA AVGCNGHIEP
//