ID   DP2L_METTH              Reviewed;        1092 AA.
AC   O27579;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   05-MAY-2009, entry version 54.
DE   RecName: Full=DNA polymerase II large subunit;
DE            Short=Pol II;
DE            EC=2.7.7.7;
GN   Name=polC; OrderedLocusNames=MTH_1536;
OS   Methanobacterium thermoautotrophicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Delta H;
RX   MEDLINE=98037514; PubMed=9371463;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA   Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA   Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA   Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA   McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA   Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum
RT   deltaH: functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Possesses two activities: a DNA synthesis (polymerase)
CC       and an exonucleolytic activity that degrades single stranded DNA
CC       in the 3'- to 5'-direction. Has a template-primer preference which
CC       is characteristic of a replicative DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts
CC       progressively in a 3'- to 5'-direction, releasing nucleoside 5'-
CC       phosphates.
CC   -!- SUBUNIT: Heterodimer of a large subunit and a small subunit (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
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DR   EMBL; AE000666; AAB86010.1; -; Genomic_DNA.
DR   PIR; H69071; H69071.
DR   RefSeq; NP_276649.1; -.
DR   GeneID; 1471805; -.
DR   GenomeReviews; AE000666_GR; MTH_1536.
DR   KEGG; mth:MTH1536; -.
DR   NMPDR; fig|187420.1.peg.1504; -.
DR   HOGENOM; O27579; -.
DR   OMA; O27579; NCDGDED.
DR   BioCyc; MTHE187420:MTH1536-MON; -.
DR   BRENDA; 2.7.7.7; 270.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:HAMAP.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0000738; P:DNA catabolic process, exonucleolytic; IEA:HAMAP.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00324; -; 1.
DR   InterPro; IPR004475; PolC_DP2.
DR   InterPro; IPR016033; PolC_DP2_N.
DR   Pfam; PF03833; PolC_DP2; 1.
DR   PIRSF; PIRSF016275; PolC_DP2; 1.
DR   TIGRFAMs; TIGR00354; polC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA-binding;
KW   DNA-directed DNA polymerase; Exonuclease; Hydrolase;
KW   Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1092       DNA polymerase II large subunit.
FT                                /FTId=PRO_0000152578.
SQ   SEQUENCE   1092 AA;  123060 MW;  AA6970F7A6F42DFF CRC64;
     MMDYFNELER ETERLYEIAR KARARGLDVS TTPEIPLAKD LAERVEGLVG PEGIARRIKE
     LEGDRGREEV AFQIAAEIAS QAVPDDDPEE REKLADQALR TALAILTEGV VAAPLEGIAR
     VRIKENFDKS RYLAVYFAGP IRSAGGTAAA LSVLIADYIR LAVGLDRYKP VEREIERYVE
     EVELYESEVT NLQYSPKPDE VRLAASKIPV EVTGEPTDKV EVSHRDLERV ETNNIRGGAL
     LAMVEGVIQK APKVLKYAKQ LKLEGWDWLE KFSKAPKKGE GEEKVVVKAD SKYVEDIIGG
     RPVLAYPSEK GAFRLRYGRA RNTGLAAMGV HPATMELLQF LAVGTQMKIE RPGKGNCVVP
     VDTIDGPVVK LRNGDVIRIE DAETASRVRS EVEEILFLGD MLVAFGEFLR NNHVLMPAGW
     CEEWWIQTIL SSPKYPGDDP LNLSYYRTRW NELEVSAGDA FRISEEYDVP LHPRYTYFYH
     DVTVRELNML REWLNTSQLE DELVLELRPE KRILEILGVP HRVKDSRVVI GHDDAHALIK
     TLRKPLEDSS DTVEALNRVS PVRIMKKAPT YIGTRVGRPE KTKERKMRPA PHVLFPIGKY
     GGSRRNIPDA AKKGSITVEI GRATCPSCRV SSMQSICPSC GSRTVIGEPG KRNINLAALL
     KRAAENVSVR KLDEIKGVEG MISAEKFPEP LEKGILRAKN DVYTFKDATI RHDSTDLPLT
     HFTPREVGVS VERLRELGYT RDCYGDELED EDQILELRVQ DVVISEDCAD YLVRVANFVD
     DLLERFYDLE RFYNVKTRED LVGHLIAGLA PHTSAAVLGR IIGFTGASAC YAHPYFHSAK
     RRNCDSDEDS VMLLLDALLN FSKSYLPSSR GGSMDAPLVL STRIDPEEID DESHNIDTMD
     MIPLEVYERS FDHPRPSEVL DVIDNVEKRL GKPEQYTGLM FSHNTSRIDE GPKVCLYKLL
     PTMKEKVESQ ITLAEKIRAV DQRSVVEGVL MSHFLPDMMG NIRAFSRQKV RCTKCNRKYR
     RIPLSGECRC GGNLVLTVSK GSVIKYLEIS KELASRYPID PYLMQRIEIL EYGVNSLFES
     DRSKQSSLDV FL
//