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Protein
Submitted name:

Heavy-metal transporting CPx-type ATPase

Gene

MTH_1535

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1537-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Heavy-metal transporting CPx-type ATPaseImported
Gene namesi
Ordered Locus Names:MTH_1535Imported
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei154 – 17219HelicalSequence analysisAdd
BLAST
Transmembranei178 – 20124HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25719HelicalSequence analysisAdd
BLAST
Transmembranei391 – 41222HelicalSequence analysisAdd
BLAST
Transmembranei418 – 44124HelicalSequence analysisAdd
BLAST
Transmembranei725 – 74824HelicalSequence analysisAdd
BLAST
Transmembranei754 – 77623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1535.

Structurei

3D structure databases

ProteinModelPortaliO27578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6967HMAInterPro annotationAdd
BLAST
Domaini71 – 13767HMAInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiarCOG01576. Archaea.
COG2217. LUCA.
KOiK17686.
OMAiQAWVQAD.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRITIRIGG MGCAACALKI EEALRKLDGI RDAAVNLVEG KVSVEYDPRR
60 70 80 90 100
VDLSDMEAAI EDAGYTVLNE NIAMAVGGMS CAMCVQKIES ALRGLEGVSN
110 120 130 140 150
ATVNLAAEKA YISYNPSLTS VEDLKRTVED LGYTVRGLEG EEISEDLKPK
160 170 180 190 200
IRRIIVGFGV SVPLMAMMYL GLQPPGGGIS MLLVSIIPFI YVSGPIFRGA
210 220 230 240 250
LRSLRSGTLD MDVMYSMGIG VAFLSSILGT AGILPSDFMF YDTALMLASF
260 270 280 290 300
LTLGRYLEAG ARGKTSEAVR RLMELQPDTA TVLRDGREVE VRIHEIDVGD
310 320 330 340 350
EVIVRPGDRV PADGKVVEGS SYVDEFMITG EPLPALKTPG SEVVAGTINT
360 370 380 390 400
DGILRFRVER TGDETFLSGI IKLVDEAQAS KPPIQRIADR AVSYFIPAVL
410 420 430 440 450
LVATSAFLFW YLVEGAGLLL SITVLISVLV VACPCALGLA TPTAVTAGIG
460 470 480 490 500
RGAELGILIK KGEALEVSDR ISCVIFDKTG TLTLGRPRVT DMVGDVLGLA
510 520 530 540 550
AALERKSRHP IAAAVTERAE EEGVDVPEAE DFRAIPGMGL EGMVDSHHVL
560 570 580 590 600
AGNRALMEKY GIPLEHWDPE KFESDGKTVV IVAVDGEVKG IIAVSDEIKP
610 620 630 640 650
GSARAVRELE RMGIGTAMIT GDNRKTAEAV AREVGIGTVI AEVLPQDKAT
660 670 680 690 700
RVAELRERGE GVAFVGDGIN DAPALAEADL GVAVGSGTDI AREAGEVVLM
710 720 730 740 750
GDDPLDVPAA LQLAGKVISR IRQNIFWAFA YNVVLIPLAA GALYPLGIVF
760 770 780 790
RPEYAGLAMA LSSVTVVSLS LTLRGYTPPA RRLREKQGEG
Length:790
Mass (Da):84,011
Last modified:January 1, 1998 - v1
Checksum:i663F5172BC74E8C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86009.1.
PIRiG69071.
RefSeqiWP_010877144.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB86009; AAB86009; MTH_1535.
GeneIDi1471804.
KEGGimth:MTH_1535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB86009.1.
PIRiG69071.
RefSeqiWP_010877144.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO27578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB86009; AAB86009; MTH_1535.
GeneIDi1471804.
KEGGimth:MTH_1535.

Phylogenomic databases

eggNOGiarCOG01576. Archaea.
COG2217. LUCA.
KOiK17686.
OMAiQAWVQAD.

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1537-MONOMER.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO27578_METTH
AccessioniPrimary (citable) accession number: O27578
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.