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O27550 (HIS1_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17
Gene names
Name:hisG
Ordered Locus Names:MTH_1506
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287ATP phosphoribosyltransferase HAMAP MF_00079
PRO_0000151886

Secondary structure

1 ................................................... 287
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O27550 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EFAA5D8BF9755F48

FASTA28731,165
        10         20         30         40         50         60 
MKIRIAVPSK GRISEPAIRL LENAGVGLKD TVNRKLFSKT QHPQIEVMFS RAADIPEFVA 

        70         80         90        100        110        120 
DGAADLGITG YDLIVERGSD VEILEDLKYG RASLVLAAPE DSTIRGPEDI PRGAVIATEF 

       130        140        150        160        170        180 
PGITENYLRE HGIDAEVVEL TGSTEIAPFI GVADLITDLS STGTTLRMNH LRVIDTILES 

       190        200        210        220        230        240 
SVKLIANRES YATKSGIIEE LRTGIRGVID AEGKRLVMLN IDRKNLDRVR ALMPGMTGPT 

       250        260        270        280 
VSEVLSDNGV VAVHAVVDEK EVFNLINRLK AVGARDILVV PIERIIP

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85981.1.
PIRH69067.
RefSeqNP_276620.1. NC_000916.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VD3X-ray2.45A/B2-287[»]
ProteinModelPortalO27550.
ModBaseSearch...

Protein-protein interaction databases

STRINGO27550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1471775.
GenomeReviewsGene locus MTH_1506 in contig AE000666_GR.
KEGGmth:MTH1506.
NMPDRfig|187420.1.peg.1475.

Phylogenomic databases

eggNOGarNOG04876.
HOGENOMHBG391868.
OMAIMLHAPS.
PhylomeDBO27550.
ProtClustDBPRK00489.

Enzyme and pathway databases

BioCycMTHE187420:MTH1506-MONOMER.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS1_METTH
AccessionPrimary (citable) accession number: O27550
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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