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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:MTH_1447
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516491 – 560Arginine--tRNA ligaseAdd BLAST560

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1447.

Structurei

3D structure databases

ProteinModelPortaliO27496.
SMRiO27496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 132"HIGH" regionAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
KOiK01887.
OMAiHVGHIRN.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRYIEKEAR DSITAALEKL GIKVPPEIKL EEPPNPQLGD LASTVSFELA
60 70 80 90 100
GKLRRAPIEI TADIMSVIET PEIFETIESK GPYINFFVDY GRFSSRLLES
110 120 130 140 150
IQDDYGSHPP RDERVILEHT SANPNGPLHI GHIRNAIIGD SLARILRMAG
160 170 180 190 200
YDVETQYYVN DMGRQIAMIV WGLLNLDGDL EDYPGDKMDH RVGKLYFEVN
210 220 230 240 250
QRLKENPGIR DEVDELIRKY EAGENEELFR KVVEYCLSGM EETMKRLHVH
260 270 280 290 300
HDRFVWEGQF VRDGTVDRVI ESLRKTGYTG ENDVLYLDLE EFGLEKELVL
310 320 330 340 350
TRSDGTSLYS TRDIAYHLQK SEEGDVIIDV LGSDHKLAAE QVGIAVELLG
360 370 380 390 400
GKRPEVIFYE FITLPEGSMS TRRGVFISVD ELMDEAHSRA LHEVKKRRDL
410 420 430 440 450
PDDVADDIAE SIGNGAIRYY IARLSPEKHI VFRWDDALSF ERGCASIQYA
460 470 480 490 500
HARACKLLEK ASFTGEEDIE DGWKPEGDER ELVRLLARFP VVVEESALAR
510 520 530 540 550
RVHPVAQYAQ DLANTFNSFY RSTPVIGSDF EGARLRLVDS VRKTLRNALN
560
LLGIHAPETM
Length:560
Mass (Da):63,648
Last modified:January 1, 1998 - v1
Checksum:i28C569A2879D672E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85922.1.
PIRiF69059.
RefSeqiWP_010877057.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85922; AAB85922; MTH_1447.
GeneIDi24854558.
KEGGimth:MTH_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85922.1.
PIRiF69059.
RefSeqiWP_010877057.1. NC_000916.1.

3D structure databases

ProteinModelPortaliO27496.
SMRiO27496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi187420.MTH1447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB85922; AAB85922; MTH_1447.
GeneIDi24854558.
KEGGimth:MTH_1447.

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
KOiK01887.
OMAiHVGHIRN.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYR_METTH
AccessioniPrimary (citable) accession number: O27496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.