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O27496 (SYR_METTH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MTH_1447
OrganismMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) [Reference proteome] [HAMAP]
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151649

Regions

Motif122 – 13211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
O27496 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 28C569A2879D672E

FASTA56063,648
        10         20         30         40         50         60 
MFRYIEKEAR DSITAALEKL GIKVPPEIKL EEPPNPQLGD LASTVSFELA GKLRRAPIEI 

        70         80         90        100        110        120 
TADIMSVIET PEIFETIESK GPYINFFVDY GRFSSRLLES IQDDYGSHPP RDERVILEHT 

       130        140        150        160        170        180 
SANPNGPLHI GHIRNAIIGD SLARILRMAG YDVETQYYVN DMGRQIAMIV WGLLNLDGDL 

       190        200        210        220        230        240 
EDYPGDKMDH RVGKLYFEVN QRLKENPGIR DEVDELIRKY EAGENEELFR KVVEYCLSGM 

       250        260        270        280        290        300 
EETMKRLHVH HDRFVWEGQF VRDGTVDRVI ESLRKTGYTG ENDVLYLDLE EFGLEKELVL 

       310        320        330        340        350        360 
TRSDGTSLYS TRDIAYHLQK SEEGDVIIDV LGSDHKLAAE QVGIAVELLG GKRPEVIFYE 

       370        380        390        400        410        420 
FITLPEGSMS TRRGVFISVD ELMDEAHSRA LHEVKKRRDL PDDVADDIAE SIGNGAIRYY 

       430        440        450        460        470        480 
IARLSPEKHI VFRWDDALSF ERGCASIQYA HARACKLLEK ASFTGEEDIE DGWKPEGDER 

       490        500        510        520        530        540 
ELVRLLARFP VVVEESALAR RVHPVAQYAQ DLANTFNSFY RSTPVIGSDF EGARLRLVDS 

       550        560 
VRKTLRNALN LLGIHAPETM 

« Hide

References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000666 Genomic DNA. Translation: AAB85922.1.
PIRF69059.
RefSeqNP_276561.1. NC_000916.1.

3D structure databases

ProteinModelPortalO27496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING187420.MTH1447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB85922; AAB85922; MTH_1447.
GeneID1471716.
KEGGmth:MTH1447.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAMEHMGFG.

Enzyme and pathway databases

BioCycMTHE187420:GJNM-1449-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METTH
AccessionPrimary (citable) accession number: O27496
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries