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O27496

- SYR_METTH

UniProt

O27496 - SYR_METTH

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTHE187420:GJNM-1449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:MTH_1447
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Arginine--tRNA ligasePRO_0000151649Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1447.

Structurei

3D structure databases

ProteinModelPortaliO27496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi122 – 13211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiMEHMGFG.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O27496-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRYIEKEAR DSITAALEKL GIKVPPEIKL EEPPNPQLGD LASTVSFELA
60 70 80 90 100
GKLRRAPIEI TADIMSVIET PEIFETIESK GPYINFFVDY GRFSSRLLES
110 120 130 140 150
IQDDYGSHPP RDERVILEHT SANPNGPLHI GHIRNAIIGD SLARILRMAG
160 170 180 190 200
YDVETQYYVN DMGRQIAMIV WGLLNLDGDL EDYPGDKMDH RVGKLYFEVN
210 220 230 240 250
QRLKENPGIR DEVDELIRKY EAGENEELFR KVVEYCLSGM EETMKRLHVH
260 270 280 290 300
HDRFVWEGQF VRDGTVDRVI ESLRKTGYTG ENDVLYLDLE EFGLEKELVL
310 320 330 340 350
TRSDGTSLYS TRDIAYHLQK SEEGDVIIDV LGSDHKLAAE QVGIAVELLG
360 370 380 390 400
GKRPEVIFYE FITLPEGSMS TRRGVFISVD ELMDEAHSRA LHEVKKRRDL
410 420 430 440 450
PDDVADDIAE SIGNGAIRYY IARLSPEKHI VFRWDDALSF ERGCASIQYA
460 470 480 490 500
HARACKLLEK ASFTGEEDIE DGWKPEGDER ELVRLLARFP VVVEESALAR
510 520 530 540 550
RVHPVAQYAQ DLANTFNSFY RSTPVIGSDF EGARLRLVDS VRKTLRNALN
560
LLGIHAPETM
Length:560
Mass (Da):63,648
Last modified:January 1, 1998 - v1
Checksum:i28C569A2879D672E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85922.1.
PIRiF69059.
RefSeqiNP_276561.1. NC_000916.1.
WP_010877057.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85922; AAB85922; MTH_1447.
GeneIDi1471716.
KEGGimth:MTH1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA. Translation: AAB85922.1 .
PIRi F69059.
RefSeqi NP_276561.1. NC_000916.1.
WP_010877057.1. NC_000916.1.

3D structure databases

ProteinModelPortali O27496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187420.MTH1447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB85922 ; AAB85922 ; MTH_1447 .
GeneIDi 1471716.
KEGGi mth:MTH1447.

Phylogenomic databases

eggNOGi COG0018.
KOi K01887.
OMAi MEHMGFG.

Enzyme and pathway databases

BioCyci MTHE187420:GJNM-1449-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiSYR_METTH
AccessioniPrimary (citable) accession number: O27496
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3