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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73Carbamoyl phosphateUniRule annotation1
Binding sitei97Carbamoyl phosphateUniRule annotation1
Binding sitei154OrnithineUniRule annotation1
Binding sitei218OrnithineUniRule annotation1
Binding sitei286Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:MTH_1446
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130691 – 301Ornithine carbamoyltransferaseAdd BLAST301

Proteomic databases

PRIDEiO27495

Interactioni

Protein-protein interaction databases

STRINGi187420.MTH1446

Structurei

3D structure databases

ProteinModelPortaliO27495
SMRiO27495
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 49Carbamoyl phosphate bindingUniRule annotation4
Regioni124 – 127Carbamoyl phosphate bindingUniRule annotation4
Regioni222 – 223Ornithine bindingUniRule annotation2
Regioni258 – 259Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912 Archaea
COG0078 LUCA
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG093Z05BF

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit
PROSITEiView protein in PROSITE
PS00097 CARBAMOYLTRANSFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

O27495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLLSVCDM DNVVDLLDLA DDYKEGKIRE KILRGKTLAM IFEKSSTRTR
60 70 80 90 100
VSFEVGAFQM GAQPLYLSAS DLQLGRGEPI ADTARTLSRY VDGIMIRAIS
110 120 130 140 150
HSDVVELAGE ASVPVINGLT DLEHPCQALA DMQTIREKLG GFDGRLVFVG
160 170 180 190 200
DGNNVCHSLL LITATLGMDM DVACPPGYEP DPGIREMAGK IADETGSRIR
210 220 230 240 250
VIHDPSEAVR GADVVYTDVW VSMGYEDEAE DRLEVFRPYQ VNMELMELAA
260 270 280 290 300
PEAIFMHCLP AVRGQETTAE VIDGPHSVVW DQAENRLHAQ KAIMHWLMGD

I
Length:301
Mass (Da):33,186
Last modified:January 1, 1998 - v1
Checksum:i2B688E2A1C58ECB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000666 Genomic DNA Translation: AAB85921.1
PIRiE69059
RefSeqiWP_010877056.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85921; AAB85921; MTH_1446
GeneIDi24854557
KEGGimth:MTH_1446
PATRICifig|187420.15.peg.1408

Similar proteinsi

Entry informationi

Entry nameiOTC_METTH
AccessioniPrimary (citable) accession number: O27495
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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