O27492 (ILVH_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable acetolactate synthase small subunit
EC=2.2.1.6

Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name=AHAS
Short name=ALS

Gene names

Name:	ilvH
Ordered Locus Names:	MTH_1443

Organism

Methanobacterium thermoautotrophicum (strain Delta H)

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
Subunit structure	Dimer of large and small chains By similarity.
Sequence similarities	Belongs to the acetolactate synthase small subunit family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetolactate synthase activity Inferred from electronic annotation. Source: EC amino acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Probable acetolactate synthase small subunit		PRO_0000151424
Regions
	Domain	9 – 82	74	ACT

Sequences

	Sequence		Length	Mass (Da)
	O27492 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: CD840CD017E1219A	FASTA	168	18,742
	10 20 30 40 50 60 MIEMEPDTHI ISALVEHKPG VLQRVAGLFT RRGFNIENIT VGESETPGIA RMTIIARGDD 70 80 90 100 110 120 RVLEQITKQL NKLIDVIKVR DLEPAATVKR ELCMVKVHAP SESERSEIIQ YTNIFRGRIV 130 140 150 160 DVSPDALTVE VTGDSEKIDA FLELLRNFGI KELARTGPTA MSRGSRTM

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85918.1.
PIR	B69059.
RefSeq	NP_276557.1. NC_000916.1.
3D structure databases
ProteinModelPortal	O27492.
ModBase	Search...
Protein-protein interaction databases
STRING	O27492.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1471712.
GenomeReviews	Gene locus MTH_1443 in contig AE000666_GR.
KEGG	mth:MTH1443.
NMPDR	fig|187420.1.peg.1412.
Phylogenomic databases
eggNOG	arNOG08992.
HOGENOM	HBG335310.
OMA	IERELAM.
PhylomeDB	O27492.
ProtClustDB	PRK11895.
Enzyme and pathway databases
BioCyc	MTHE187420:MTH1443-MONOMER.
Family and domain databases
InterPro	IPR004789. Acetalactate_synth_ssu. IPR019455. Acetolactate_synth_ssu_C. IPR002912. ACT-bd. [Graphical view]
KO	K01653.
Pfam	PF01842. ACT. 1 hit. PF10369. ALS_ss_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00119. Acolac_sm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVH_METTH

Accession

Primary (citable) accession number: O27492

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program