O27479 (UPPP_METTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	MTH_1428

Organism

Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) [Reference proteome] [HAMAP]

Taxonomic identifier

187420 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter › Methanobacterium thermoformicicum

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151252
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	161 – 181	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O27479 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 82D1F852B3E90851	FASTA	181	19,211
	10 20 30 40 50 60 MVIIGTVPAG LAGVLFKDFF ESLFSSLTAV GFFLLVTGFL LWGSENISRR VREKLPVEKL 70 80 90 100 110 120 GVRESLIIGC AQALAIAPGI SRSGATISAG LFLGFERELA ARYSFLLSIP AILGAALIQI 130 140 150 160 170 180 KDIGAGMNLL GASMVAGFAA AAVSGYIAIK FLLKLIKERD LYIFAYYCWA LGIMILAAAL I

References

[1]

"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics." Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N. J. Bacteriol. 179:7135-7155(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000666 Genomic DNA. Translation: AAB85905.1.
PIR	C69057.
RefSeq	NP_276544.1. NC_000916.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	187420.MTH1428.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB85905; AAB85905; MTH_1428.
GeneID	1471145.
KEGG	mth:MTH1428.
Phylogenomic databases
eggNOG	COG1968.
KO	K06153.
OMA	FTPFAIW.
Enzyme and pathway databases
BioCyc	MTHE187420:GJNM-1430-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. Divergent sequence.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_METTH

Accession

Primary (citable) accession number: O27479

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program