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O27475 (O27475_METTH) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405
Gene names
Ordered Locus Names:MTH_1424 EMBL AAB85901.1
OrganismMethanobacterium thermoautotrophicum (strain Delta H)
Taxonomic identifier187420 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanothermobacter

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region7 – 126Substrate binding By similarity HAMAP MF_01405
Region64 – 652Substrate binding By similarity HAMAP MF_01405

Sites

Metal binding361Magnesium or manganese By similarity HAMAP MF_01405
Metal binding641Magnesium or manganese By similarity HAMAP MF_01405
Binding site1431Substrate By similarity HAMAP MF_01405
Binding site1631Substrate By similarity HAMAP MF_01405
Binding site1691Substrate By similarity HAMAP MF_01405

Sequences

Sequence LengthMass (Da)Tools
O27475 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 506186702D19B9AD

FASTA18721,127
        10         20         30         40         50         60 
MKVTFITGNK HKLSEAEKIF HGTGIELMHA DLGYPELQGT LEEVARYGAE HAARIMDGPV 

        70         80         90        100        110        120 
IVEDAGLFIR ALKWFPGPYS AYVQDTIGNR GILKLMENVE DRYAEFRSAV GFCTPNSEPE 

       130        140        150        160        170        180 
VFLGVVKGRI GTEERGTMGF AFDPLFYPEG MDKSFGELST SEKNRFSHRS RALKKFAEWY 


IENYEVI

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References

[1]"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics."
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R. expand/collapse author list , Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.
J. Bacteriol. 179:7135-7155(1997) [PubMed: 9371463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Delta H.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000666 Genomic DNA. Translation: AAB85901.1.
PIRG69056.
RefSeqNP_276540.1. NC_000916.1.

3D structure databases

HSSPHSSP built from PDB template 1B78 based on UniProtKB Q57679.
ProteinModelPortalO27475.
ModBaseSearch...

Protein-protein interaction databases

STRINGO27475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1471141.
GenomeReviewsGene locus MTH_1424 in contig AE000666_GR.
KEGGmth:MTH1424.
NMPDRfig|187420.1.peg.1395.

Phylogenomic databases

eggNOGarNOG10472.
HOGENOMHBG697237.
OMAVEDSGFF.
PhylomeDBO27475.
ProtClustDBCLSK798170.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameO27475_METTH
AccessionPrimary (citable) accession number: O27475
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info